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The diverse structural modes of tRNA binding and recognition

期刊: JOURNAL OF BIOLOGICAL CHEMISTRY, 2023; 299 (8)

tRNAs are short noncoding RNAs responsible for decoding mRNA codon triplets, delivering correct amino acids to the ribosome, and mediating polypeptide......

Development of a V5-tag-directed nanobody and its implementation as an intracellular biosensor of GPCR signaling

期刊: JOURNAL OF BIOLOGICAL CHEMISTRY, 2023; 299 (9)

Protein-protein interactions (PPIs) form the foundation of any cell signaling network. Considering that PPIs are highly dynamic processes, cellular as......

Comparative analysis of N-terminal cysteine dioxygenation and prolyl-hydroxylation as oxygen-sensing pathways in mammalian cells

期刊: JOURNAL OF BIOLOGICAL CHEMISTRY, 2023; 299 (9)

In animals, adaptation to changes in cellular oxygen levels is coordinated largely by 2-oxoglutarate-dependent prolylhydroxylase domain (PHD) dioxygen......

Rho family small GTPase Rif regulates Wnt5a-Ror1-Dvl2 signaling and promotes lung adenocarcinoma progression

期刊: JOURNAL OF BIOLOGICAL CHEMISTRY, 2023; 299 (10)

Rho in filopodia (Rif), a member of the Rho family of small GTPases, induces filopodia formation primarily on the dorsal surface of cells; however, it......

Phosphate uptake restriction, phosphate export, and polyphosphate synthesis contribute synergistically to cellular proliferation and survival

期刊: JOURNAL OF BIOLOGICAL CHEMISTRY, 2023; 299 (12)

Phosphate (Pi) is a macronutrient, and Pi homeostasis is essential for life. Pi homeostasis has been intensively studied; however, many questions rema......

Fine spectral tuning of a flavin-binding fluorescent protein for multicolor imaging

期刊: JOURNAL OF BIOLOGICAL CHEMISTRY, 2023; 299 (3)

Flavin-binding fluorescent proteins are promising geneti-cally encoded tags for microscopy. However, spectral properties of their chromophores (ribofl......

Crosstalk of protein clearance, inflammasome, and Ca2+ channels in retinal pigment epithelium derived from age- related macular degeneration patients

期刊: JOURNAL OF BIOLOGICAL CHEMISTRY, 2023; 299 (6)

Degeneration and/or dysfunction of retinal pigment epithelium (RPE) is generally detected as the formation of intracellular and extracellular protein ......

Actin-binding protein filamin B regulates the cell-surface retention of endothelial sphingosine 1-phosphate receptor 1

期刊: JOURNAL OF BIOLOGICAL CHEMISTRY, 2023; 299 (7)

Sphingosine 1 -phosphate receptor 1 (S1PR1) is a G protein- coupled receptor essential for vascular development and postnatal vascular homeostasis. Wh......

Saccharomyces cerevisiae Δ9-desaturase Ole1 forms a supercomplex with Slc1 and Dga1

期刊: JOURNAL OF BIOLOGICAL CHEMISTRY, 2023; 299 (7)

Biosynthesis of the various lipid species that compose cellular membranes and lipid droplets depends on the activity of multiple enzymes functioning i......

A cane toad (Rhinella marina) N-methyltransferase converts primary indolethylamines to tertiary psychedelic amines

期刊: JOURNAL OF BIOLOGICAL CHEMISTRY, 2023; 299 (10)

Psychedelic indolethylamines have emerged as potential medicines to treat several psychiatric pathologies. Natural sources of these compounds include ......

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