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Long non-coding RNA RNF7 promotes the cardiac fibrosis in rat model via miR-543/THBS1 axis and TGF beta 1 activation

期刊: AGING-US, 2020; 12 (1)

Cardiac fibrosis (CF) is regulated by multiple factors, including transforming growth factor beta 1 (TGF beta 1) and non-coding RNAs. Thrombospondin 1......

Prediction of hepatocellular carcinoma prognosis based on expression of an immune-related gene set

期刊: AGING-US, 2020; 12 (1)

Hepatocellular carcinoma (HCC) is a common type of malignant tumor with an extremely poor prognosis. Because many HCC patients are diagnosed with adva......

Systematic analysis of lncRNA and microRNA dynamic features reveals diagnostic and prognostic biomarkers of myocardial infarction

期刊: AGING-US, 2020; 12 (1)

Analyses of long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) implicated in myocardial infarction (MI) have increased our understanding of gene re......

Upregulation of flavin-containing monooxygenase 3 mimics calorie restriction to retard liver aging by inducing autophagy

期刊: AGING-US, 2020; 12 (1)

Flavin-containing monooxygenase 3 (FMO3) gene expression is often upregulated in long-lived murine models. However, the specific relationship between ......

Prognostic potential of PRPF3 in hepatocellular carcinoma

期刊: AGING-US, 2020; 12 (1)

pre-mRNA processing factor 3 (PRPF3) is an RNA binding protein in a core component of the exon junction complex. Abnormal PRPF3 expression is potentia......

SAG expression associates with COPB2-related signaling and a poorer prognosis in breast cancer

期刊: AGING-US, 2020; 12 (1)

SAG is an essential RING component of the Cullin-RING ligase (CRL) E3 ubiquitin ligase complex, which regulates diverse signaling pathways and biologi......

Prognostic value of epithelial-mesenchymal transition markers in clear cell renal cell carcinoma

期刊: AGING-US, 2020; 12 (1)

Epithelial-to-mesenchymal transition (EMT) is important in tumor invasiveness and metastasis. We aimed to determine prognostic value of six key EMT ma......

Surgery/Anesthesia disturbs mitochondrial fission/fusion dynamics in the brain of aged mice with postoperative delirium

期刊: AGING-US, 2020; 12 (1)

Postoperative delirium (POD) is a common complication following surgery and anesthesia (Surgery/Anesthesia). Mitochondrial dysfunction, which is demon......

Association between SOD2 V16A variant and urological cancer risk

期刊: AGING-US, 2020; 12 (1)

Background: The correlation between superoxide dismutase 2 (SOD2) V16A variant and urological cancer susceptibility has been widely studied, however, ......

Low-abundance mutations in colorectal cancer patients and healthy adults

期刊: AGING-US, 2020; 12 (1)

Detecting low-abundance mutations is very important for cancer diagnosis and treatment. Here we describe an improved targeted sequencing analysis that......

CCL14 is a prognostic biomarker and correlates with immune infiltrates in hepatocellular carcinoma

期刊: AGING-US, 2020; 12 (1)

C-C motif chemokine ligand 14 (CCL14) is a chemokine promoting the activation of immune cells. However, the relationship between CCL14 expression, tum......

Six-gene signature for predicting survival in patients with head and neck squamous cell carcinoma

期刊: AGING-US, 2020; 12 (1)

The prognosis of head and neck squamous cell carcinoma (HNSCC) patients remains poor. High-throughput sequencing data have laid a solid foundation for......

Germline mutation of TSC1 or TSC2 gene in Chinese patients with bilateral renal angiomyolipomas and mutation spectrum of Chinese TSC patients

期刊: AGING-US, 2020; 12 (1)

The germline mutation of the TSC1/2 gene in bilateral renal angiomyolipomas is unclear. Meanwhile, the mutation spectrum of Chinese TSC patients has n......

Integrated transcriptome expression profiling reveals a novel lncRNA associated with L-DOPA-induced dyskinesia in a rat model of Parkinson's disease

期刊: AGING-US, 2020; 12 (1)

Levodopa-induced dyskinesia (LID) is a common complication of chronic dopamine replacement therapy in the treatment of Parkinson's disease (PD). Long ......

LncRNA KCNQ1OT1 regulates microRNA-9-LMX1A expression and inhibits gastric cancer cell progression

期刊: AGING-US, 2020; 12 (1)

LMX1A (LIM homeobox transcription factor 1 alpha) is a tumor suppressor protein. Our previous study has shown that microRNA-9 ("miR-9"), being upregul......

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