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YAP transduction drives triple-negative breast cancer aggressiveness through modulating the EGFR-AKT axis in patient-derived xenograft cells

期刊: MEDICAL ONCOLOGY, 2023; 40 (5)

Aside from the high prevalence of incidents of breast cancer, the high grade of heterogeneity and the dearth of standard treatment guidelines make tri......

Classification of triple-negative breast cancer based on pathway enrichment levels

期刊: MEDICAL ONCOLOGY, 2023; 40 (6)

Triple-negative breast cancer (TNBC) is highly heterogeneous in the stromal and immune microenvironment, genome integrity, oncogenic signatures, and m......

Vitamin-based radiopharmaceuticals for tumor imaging

期刊: MEDICAL ONCOLOGY, 2023; 40 (6)

Advances in nuclear medicine, such as single photon emission computed tomography (SPECT) and positron emission tomography (PET), are among the most se......

Identification of glycogen phosphorylase L as a potential target for lung cancer

期刊: MEDICAL ONCOLOGY, 2023; 40 (7)

Traditional Chinese medicine (TCM) has been widely used for cancer treatment. Identification of anti-cancer targets of TCM is the first and principal ......

Oncolytic viruses against cancer, promising or delusion?

期刊: MEDICAL ONCOLOGY, 2023; 40 (8)

Cancer treatment is one of the most challenging topics in medical sciences. Different methods such as chemotherapy, tumor surgery, and immune checkpoi......

Inhibition of IRE1 RNase activity modulates tumor cell progression and enhances the response to chemotherapy in colorectal cancer

期刊: MEDICAL ONCOLOGY, 2023; 40 (9)

Drug resistance is one of the clinical challenges that limits the effectiveness of chemotherapy. Recent reports suggest that the unfolded protein resp......

RNF149 confers cisplatin resistance in esophageal squamous cell carcinoma via destabilization of PHLPP2 and activating PI3K/AKT signalling

期刊: MEDICAL ONCOLOGY, 2023; 40 (10)

Chemo-resistance has been identified as a crucial factor contributing to tumor recurrence and a leading cause of worse prognosis in patients with ESCC......

Decoding dysregulated angiogenesis in HTLV-1 asymptomatic carriers compared to healthy individuals

期刊: MEDICAL ONCOLOGY, 2023; 40 (11)

Human T-cell lymphotropic virus type 1 (HTLV-1) is the first identified human retrovirus responsible for two significant diseases: HTLV-1-associated m......

Synergistic induction of apoptosis in liver cancer cells: exploring the combined potential of doxorubicin and XL-888

期刊: MEDICAL ONCOLOGY, 2023; 40 (11)

Combination therapy has been frequently preferred in treating various types of cancer in recent years. Targeted cancer therapy has also become one of ......

SRC-3/TRAF4 facilitates ovarian cancer development by activating the PI3K/AKT signaling pathway

期刊: MEDICAL ONCOLOGY, 2023; 40 (2)

Objective Ovarian cancer is the seventh most common cancer in women, and it causes many deaths in women worldwide. Patients with ovarian cancer have a......

Investigation of the TLR4 and IRF3 signaling pathway-mediated effects of monensin in colorectal cancer cells

期刊: MEDICAL ONCOLOGY, 2023; 40 (7)

Monensin is an ionophore antibiotic isolated from Streptomyces cinnamonensis with very strong antibacterial and antiparasitic effects. Although monens......

Comparison of the immunotherapy efficacy between invasive mucinous and non-mucinous adenocarcinoma in advanced lung cancer patients with KRAS mutation: a retrospective study

期刊: MEDICAL ONCOLOGY, 2023; 40 (7)

Invasive mucinous adenocarcinoma (IMA) is a rare variant of adenocarcinoma with unique clinical, radiological, and pathological features, among which ......

The crosstalk between ubiquitin-conjugating enzyme E2Q1 and p53 in colorectal cancer: An in vitro analysis

期刊: MEDICAL ONCOLOGY, 2023; 40 (7)

Colorectal cancer (CRC) is a prevalent gastrointestinal neoplasm that ranks fourth in terms of cancer-related deaths worldwide. In the process of CRC ......

Concomitant effects of paclitaxel and celecoxib on genes involved in apoptosis of triple-negative metastatic breast cancer cells

期刊: MEDICAL ONCOLOGY, 2023; 40 (9)

Although triple-negative breast cancer accounts for less than one-fifth of breast cancers, it has a higher rate of metastasis and mortality. This stud......

Toxoplasma gondii-derived antigen modifies tumor microenvironment of Ehrlich solid carcinoma murine model and enhances immunotherapeutic activity of cyclophosphamide

期刊: MEDICAL ONCOLOGY, 2023; 40 (5)

Pathogen-based cancer vaccine is a promising immunotherapeutic weapon to stimulate cancer immunosuppressive state. Toxoplasma gondii is a potent immun......

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