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Saikosaponin D Rescues Deficits in Sexual Behavior and Ameliorates Neurological Dysfunction in Mice Exposed to Chronic Mild Stress

期刊: FRONTIERS IN PHARMACOLOGY, 2021; 12 ()

Often associated with sexual dysfunction (SD), chronic stress is the main contributing risk factor for the pathogenesis of depression. Radix bupleuri ......

Methamphetamine and HIV-Tat Protein Synergistically Induce Oxidative Stress and Blood-Brain Barrier Damage via Transient Receptor Potential Melastatin 2 Channel

期刊: FRONTIERS IN PHARMACOLOGY, 2021; 12 ()

Synergistic impairment of the blood-brain barrier (BBB) induced by methamphetamine (METH) and HIV-Tat protein increases the risk of HIV-associated neu......

High Expression of Lysophosphatidic Acid Induces Nerve Injury in LSS Patients via AKT Mediated NF-kappa B p65 Pathway

期刊: FRONTIERS IN PHARMACOLOGY, 2021; 12 ()

Lumbar spinal stenosis (LSS) is a spinal degenerative disease, complicated with nerve injury. Lysophosphatidic acid (LPA), a kind of glycerophospholip......

The Efficacy of Ginsenoside Rg3 Combined with First-line Chemotherapy in the Treatment of Advanced Non-Small Cell Lung Cancer in China: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

期刊: FRONTIERS IN PHARMACOLOGY, 2021; 11 ()

Background: For advanced non-small cell lung cancer (NSCLC) patients, first-line chemotherapy is the main treatment in the clinic despite its efficacy......

Study of the Mechanism of Action of Guanxin Shutong Capsules in the Treatment of Coronary Heart Disease Based on Metabolomics

期刊: FRONTIERS IN PHARMACOLOGY, 2021; 12 ()

Background: Guan-Xin-Shu-Tong capsule (GXSTC) is a traditional Chinese medicine (TCM) that has been used to treat coronary heart disease (CHD) for man......

Pharmacokinetics, Bioavailability, Excretion and Metabolism Studies of Akebia Saponin D in Rats: Causes of the Ultra-Low Oral Bioavailability and Metabolic Pathway

期刊: FRONTIERS IN PHARMACOLOGY, 2021; 12 ()

Background: Akebia saponin D (ASD) has a variety of biological activities and great medicinal potential, but its oral bioavailability is so low as to ......

The Tetramethylpyrazine Derivative Statmp-151: A Novel Small Molecule Stat3 Inhibitor With Promising Activity Against Breast Cancer

期刊: FRONTIERS IN PHARMACOLOGY, 2021; 12 ()

Breast cancer is the most common malignancy in women and is a molecularly heterogeneous disease. Signal transducer and activator of transcription 3 (S......

The Hypoxia-Activated Prodrug TH-302: Exploiting Hypoxia in Cancer Therapy

期刊: FRONTIERS IN PHARMACOLOGY, 2021; 12 ()

Hypoxia is an important feature of most solid tumors, conferring resistance to radiation and many forms of chemotherapy. However, it is possible to ex......

Neuroprotective Effect for Cerebral Ischemia by Natural Products: A Review

期刊: FRONTIERS IN PHARMACOLOGY, 2021; 12 ()

Natural products have a significant role in the prevention of disease and boosting of health in humans and animals. Stroke is a disease with high prev......

Bibliometric Analysis of Global Research Trends on Ultrasound Microbubble: A Quickly Developing Field

期刊: FRONTIERS IN PHARMACOLOGY, 2021; 12 ()

Background: Microbubbles are widely used as highly effective contrast agents to improve the diagnostic capability of ultrasound imaging. Mounting evid......

Aldehyde Dehydrogenase 2 Protects Against Lipopolysaccharide-Induced Myocardial Injury by Suppressing Mitophagy

期刊: FRONTIERS IN PHARMACOLOGY, 2021; 12 ()

Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Sepsis-induced circulatory and cardiac dy......

Catenin Alpha-2 Mutation Changes the Immune Microenvironment in Lung Adenocarcinoma Patients Receiving Immune Checkpoint Inhibitors

期刊: FRONTIERS IN PHARMACOLOGY, 2021; 12 ()

Background: Lung cancer has always been the most prevalent cancer. Lung adenocarcinoma (LUAD) is the most common lung cancer subtype and has a high tu......

Unsupervised Hierarchical Clustering Identifies Immune Gene Subtypes in Gastric Cancer

期刊: FRONTIERS IN PHARMACOLOGY, 2021; 12 ()

Objectives: The pathogenesis of heterogeneity in gastric cancer (GC) is not clear and presents as a significant obstacle in providing effective drug t......

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