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Nasal prevention of SARS-CoV-2 infection by intranasal influenza-based boost vaccination in mouse models

期刊: EBIOMEDICINE, 2022; 75 ()

Background Vaccines in emergency use are efficacious against COVID-19, yet vaccine-induced prevention against nasal SARS-CoV-2 infection remains subop......

JIF:5.573

Large-scale network dysfunction in a-Synucleinopathy: A meta-analysis of resting-state functional connectivity

期刊: EBIOMEDICINE, 2022; 77 ()

Background Although dysfunction of large-scale brain networks has been frequently demonstrated in patients with a-Synucleinopathy (alpha-Syn, i.e., Pa......

JIF:5.573

Mesenchymal stem cell treatment for COVID-19

期刊: EBIOMEDICINE, 2022; 77 ()

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has caused a global pandemic since late 2019 that resulted in more than 360 mil......

JIF:5.573

Effects of RAS inhibitors on all-site cancers and mortality in the Hong Kong diabetes surveillance database (2002-2019)

期刊: EBIOMEDICINE, 2022; 83 ()

Background Cancer is replacing cardiovascular-disease as a leading cause of death in type 2 diabetes (T2D). The association of RAS-inhibitors (RASi) a......

JIF:5.573

Replication of SARS-CoV-2 Omicron BA.2 variant in ex vivo cultures of the human upper and lower respiratory tract

期刊: EBIOMEDICINE, 2022; 83 ()

Background The Omicron BA.2 sublineage has replaced BA.1 worldwide and has comparable levels of immune evasion to BA.1. These observations suggest tha......

JIF:5.573

Inhibition of HIPK2 protects stress-induced pathological cardiac remodeling

期刊: EBIOMEDICINE, 2022; 85 ()

Background Homeodomain-Interacting Protein Kinase 2 (HIPK2) has been reported to maintain basal cardiac func-tion, however, its role in pathological c......

JIF:5.573

Epigenomic landscape study reveals molecular subtypes and EBV-associated regulatory epigenome reprogramming in nasopharyngeal carcinoma

期刊: EBIOMEDICINE, 2022; 86 ()

Background Epstein-Barr virus (EBV) latent infection is associated with genome-wide epigenomic changes in several malignancies, but its role in epigen......

JIF:5.573

Contribution of ferroptosis and GPX4's dual functions to osteoarthritis progression

期刊: EBIOMEDICINE, 2022; 76 ()

Background Osteoarthritis (OA) is the most common joint disease and is the leading cause of chronic disability among older people. Chondrocyte death a......

JIF:5.573

Dysregulated lipid metabolism blunts the sensitivity of cancer cells to EZH2 inhibitor

期刊: EBIOMEDICINE, 2022; 77 ()

Background Sensitivity has been a key issue for Enhancer of zeste homolog 2 (EZH2) inhibitors in cancer therapy. The EZH2 inhibitor EPZ-6438 was first......

JIF:5.573

New diagnostic and therapeutic strategies for myocardial infarction via nanomaterials

期刊: EBIOMEDICINE, 2022; 78 ()

Myocardial infarction is lethal to patients because of insufficient blood perfusion to vital organs. Several attempts have been made to improve its pr......

JIF:5.573

KIBRA regulates amyloid beta metabolism by controlling extracellular vesicles secretion

期刊: EBIOMEDICINE, 2022; 78 ()

Background Previous research has revealed that KIBRA controls secretion of extracellular vesicles (EVs) by inhibiting the proteasomal degradation of R......

JIF:5.573

Longer screen time utilization is associated with the polygenic risk for Attention-deficit/hyperactivity disorder with mediation by brain white matter microstructure

期刊: EBIOMEDICINE, 2022; 80 ()

Background Attention-deficit/hyperactivity disorder (ADHD) has been reported to be associated with longer screen time utilization (STU) at the behavio......

JIF:5.573

Human endogenous retrovirus-H long terminal repeat-associating 2: The next immune checkpoint for antitumour therapy

期刊: EBIOMEDICINE, 2022; 79 ()

Human endogenous retrovirus-H long terminal repeat-associating 2 (HHLA2) is a newly emerging immune checkpoint that belongs to B7 family. HHLA2 has a ......

JIF:5.573

Integrative analysis prioritised oxytocin-related biomarkers associated with the aetiology of autism spectrum disorder

期刊: EBIOMEDICINE, 2022; 81 ()

Background Autism spectrum disorder (ASD) is a neurodevelopmental disorder with high phenotypic and genetic heterogeneity. The common variants of spec......

JIF:5.573

Landscape of exitrons in gastric cancer

期刊: EBIOMEDICINE, 2022; 84 ()

Background Exitron is a new type of non-canonical alternative splicing. Accumulating evidence implies exitron may have pathological function and contr......

JIF:5.573

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