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Formyl peptide receptor 2 as a potential therapeutic target for inflammatory bowel disease

期刊: ACTA PHARMACOLOGICA SINICA, 2023; 44 (1)

Inflammatory bowel disease (IBD) is a global health burden whose existing treatment is largely dependent on anti-inflammatory agents. Despite showing ......

Pramipexole inhibits astrocytic NLRP3 inflammasome activation via Drd3-dependent autophagy in a mouse model of Parkinson's disease

期刊: ACTA PHARMACOLOGICA SINICA, 2023; 44 (1)

Inflammation is one of the pathogenic processes in Parkinson's disease (PD). Dopamine receptor agonist pramipexole (PPX) is extensively used for PD tr......

Thoracic perivascular adipose tissue inhibits VSMC apoptosis and aortic aneurysm formation in mice via the secretome of browning adipocytes

期刊: ACTA PHARMACOLOGICA SINICA, 2023; 44 (2)

Abdominal aortic aneurysm (AAA) is a dangerous vascular disease without any effective drug therapies so far. Emerging evidence suggests the phenotypic......

TRPV4 channel is involved in HSV-2 infection in human vaginal epithelial cells through triggering Ca2+ oscillation

期刊: ACTA PHARMACOLOGICA SINICA, 2023; 44 (4)

Herpes simplex virus (HSV) infection induces a rapid and transient increase in intracellular calcium concentration ([Ca2+](i)), which plays a critical......

Aurantio-obtusin ameliorates obesity by activating PPARα-dependent mitochondrial thermogenesis in brown adipose tissues

期刊: ACTA PHARMACOLOGICA SINICA, 2023; ()

Obesity contributes to the progression of various chronic diseases, and shortens life expectancy. With abundant mitochondria, brown adipose tissue (BA......

Metrnl deficiency retards skin wound healing in mice by inhibiting AKT/eNOS signaling and angiogenesis

期刊: ACTA PHARMACOLOGICA SINICA, 2023; ()

Meteorin-like (Metrnl) is a novel secreted protein with various biological activities. In this study, we investigated whether and how Metrnl regulated......

Acetyl-CoA synthetase 2 promotes diabetic renal tubular injury in mice by rewiring fatty acid metabolism through SIRT1/ChREBP pathway

期刊: ACTA PHARMACOLOGICA SINICA, 2023; ()

Diabetic nephropathy (DN) is characterized by chronic low-grade renal inflammatory responses, which greatly contribute to disease progression. Abnorma......

Chemokine CCL2 promotes cardiac regeneration and repair in myocardial infarction mice via activation of the JNK/STAT3 axis

期刊: ACTA PHARMACOLOGICA SINICA, 2023; ()

Stimulation of adult cardiomyocyte proliferation is a promising strategy for treating myocardial infarction (MI). Earlier studies have shown increased......

1-Indanone retards cyst development in ADPKD mouse model by stabilizing tubulin and down-regulating anterograde transport of cilia

期刊: ACTA PHARMACOLOGICA SINICA, 2023; 44 (2)

Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disease. Cyst development in ADPKD involves abnormal epitheli......

Adriamycin induces cardiac fibrosis in mice via PRMT5-mediated cardiac fibroblast activation

期刊: ACTA PHARMACOLOGICA SINICA, 2023; 44 (3)

Long-term treatment with adriamycin (ADR) is associated with higher incidences of cumulative cardiotoxicity manifest as heart failure. ADR-induced car......

Endothelial dysfunction in COVID-19: an overview of evidence, biomarkers, mechanisms and potential therapies

期刊: ACTA PHARMACOLOGICA SINICA, 2023; 44 (4)

The fight against coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 infection is still raging. However, the pathophysiology of acute and post-a......

Comparison of two methods for tumour-targeting peptide modification of liposomes

期刊: ACTA PHARMACOLOGICA SINICA, 2023; 44 (4)

Liposomes decorated with tumour-targeting cell-penetrating peptides can enhance specific drug delivery at the tumour site. The TR peptide, c(RGDfK)-AG......

JP1, a polypeptide specifically targeting integrin αVβ3, ameliorates choroidal neovascularization and diabetic retinopathy in mice

期刊: ACTA PHARMACOLOGICA SINICA, 2023; 44 (4)

Anti-vascular endothelial growth factor (VEGF) drugs have revolutionized the treatment of neovascular eye diseases, but responses are incomplete in so......

Ferroptosis inhibitor liproxstatin-1 alleviates metabolic dysfunction-associated fatty liver disease in mice: potential involvement of PANoptosis

期刊: ACTA PHARMACOLOGICA SINICA, 2023; 44 (5)

Ferroptosis is a new form of regulated cell death characterized by excessive iron accumulation and uncontrollable lipid peroxidation. The role of ferr......

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