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Retinal protective effect of curcumin metabolite hexahydrocurcumin against blue light-induced RPE damage

期刊: PHYTOMEDICINE, 2023; 110 ()

Background: Age-related macular degeneration (AMD) is a disease of retinal pigment epithelium (RPE) cells. We have previously demonstrated that blue l......

New advances in Nrf2-mediated analgesic drugs

期刊: PHYTOMEDICINE, 2023; 110 ()

Background: Oxidative stress is an inevitable process that occurs during life activities, and it can participate in the development of inflammation. A......

Chinese herbal medicine alleviates the pathogenesis of polycystic ovary syndrome by improving oxidative stress and glucose metabolism via mitochondrial Sirtuin 3 signaling

期刊: PHYTOMEDICINE, 2023; 109 ()

Background: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders among women, and the curative effects of its current manage......

Salidroside intensifies mitochondrial function of CoCl2-damaged HT22 cells by stimulating PI3K-AKT-MAPK signaling pathway

期刊: PHYTOMEDICINE, 2023; 109 ()

Background: Salidroside (Sal), an active component from Rhodiola crenulata, has been confirmed to exert neu-roprotective effects against hypoxia. Howe......

Improvement of obesity by Liupao tea is through the IRS-1/PI3K/AKT/GLUT4 signaling pathway according to network pharmacology and experimental verification

期刊: PHYTOMEDICINE, 2023; 110 ()

Background: Obesity is a state of accumulating excessive body fat, charactering by a high blood lipid and associating with various metabolic diseases.......

Transcriptome profiling Revealed the potential mechanisms of Shen Lin Bai Zhu San n-butanol extract on DSS induced Colitis in Mice and LC-MS analysis

期刊: PHYTOMEDICINE, 2023; 110 ()

Background: Inflammatory bowel disease (IBD) is a chronic and recurrent inflammatory disorder in gastrointestinal tract. Shen Ling Bai Zhu San (SLBZS)......

The pivotal role of JAK/STAT and IRS/PI3K signaling pathways in neurodegenerative diseases: Mechanistic approaches to polyphenols and alkaloids

期刊: PHYTOMEDICINE, 2023; 112 ()

Background: Neurodegenerative diseases (NDDs) are characterized by progressive neuronal dysfunctionality which results in disability and human life-th......

Zuogui-Jiangtang-Yishen decoction prevents diabetic kidney disease: Intervene pyroptosis induced by trimethylamine n-oxide through the mROS-NLRP3 axis

期刊: PHYTOMEDICINE, 2023; 114 ()

Background: Nowadays, diabetic kidney disease (DKD) has become one of the most threatening to the end-stage renal diseases, and the early prevention o......

Ponicidin inhibited gallbladder cancer proliferation and metastasis by decreasing MAGEB2 expression through FOXO4

期刊: PHYTOMEDICINE, 2023; 114 ()

Background: Gallbladder cancer (GBC) is the most aggressively malignant tumor in the bile duct system. The prognosis for patients with GBC is extremel......

Dendrobium as a new natural source of bioactive for the prevention and treatment of digestive tract diseases: A comprehensive review with future perspectives

期刊: PHYTOMEDICINE, 2023; 114 ()

Background: The incidence of diseases related to the digestive tract is on the rise, with many types of complex etiologies. Dendrobium nobile Lindl. i......

A novel purgative mechanism of multiflorin A involves changing intestinal glucose absorption and permeability

期刊: PHYTOMEDICINE, 2023; 114 ()

Background: Multiflorin A (MA) is a potential active ingredient of traditional herbal laxative, Pruni semen, with unusual purgative activity and an un......

RNA-binding domain 2 of nucleolin is important for the autophagy induction of curcumol in nasopharyngeal carcinoma cells

期刊: PHYTOMEDICINE, 2023; 115 ()

Background & Aims: Excessive autophagy induces cell death and is regarded as the treatment of cancer therapy. We have confirmed that the anti-canc......

The evidence framework of traditional Chinese medicine injection (Aidi injection) in controlling malignant pleural effusion: A clustered systematic review and meta-analysis

期刊: PHYTOMEDICINE, 2023; 115 ()

Introduction: Aidi injection (Aidi), a traditional Chinese medicine injection, is often practiced to control malig-nant pleural effusion (MPE). Object......

Amentoflavone mitigates doxorubicin-induced cardiotoxicity by suppressing cardiomyocyte pyroptosis and inflammation through inhibition of the STING/NLRP3 signalling pathway

期刊: PHYTOMEDICINE, 2023; 117 ()

Background: Doxorubicin (DOX) is a potent anticancer chemotherapeutic agent whose clinical application is substantially constrained by its cardiotoxic......

System analysis of Huang-Lian-Jie-Du-Tang and their key active ingredients for overcoming CML resistance by suppression of leukemia stem cells

期刊: PHYTOMEDICINE, 2023; 117 ()

Background: BCR-ABL1-based resistance to imatinib, mainly resulting from BCR-ABL1 mutations, is largely solved after second-and third-generation tyros......

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