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Metastatic heterogeneity of breast cancer: Molecular mechanism and potential therapeutic targets

期刊: SEMINARS IN CANCER BIOLOGY, 2020; 60 ()

Breast cancer is one of the most common malignancies among women throughout the world and is the major cause of most cancer-related deaths. Several ex......

Translational genomics of nasopharyngeal cancer

期刊: SEMINARS IN CANCER BIOLOGY, 2020; 61 ()

Nasopharyngeal carcinoma (NPC), also named the Cantonese cancer, is a unique cancer with strong etiological association with infection of the Epstein-......

The role of heparan sulfate maturation in cancer: A focus on the 3O-sulfation and the enigmatic 3O-sulfotransferases (HS3STs)

期刊: SEMINARS IN CANCER BIOLOGY, 2020; 62 ()

Heparansulfate (HS) modifications are master regulators of the cross-talk between cell and matrix and modulate the biological activity of an array of ......

SRY-related high-mobility-group box 4: Crucial regulators of the EMT in cancer

期刊: SEMINARS IN CANCER BIOLOGY, 2020; 67 ()

The epithelial-mesenchymal transition (EMT) is a process of cell transformation under certain physiological and pathological states in which epithelia......

The functions and regulation of Smurfs in cancers

期刊: SEMINARS IN CANCER BIOLOGY, 2020; 67 ()

Smad ubiquitination regulatory factor 1 (Smurf1) and Smurf2 are HECT-type E3 ubiquitin ligases, and both Smurfs were initially identified to regulate ......

Novel role of the SRY-related high-mobility-group box D gene in cancer

期刊: SEMINARS IN CANCER BIOLOGY, 2020; 67 ()

The SRY-related high-mobility-group box (Sox) gene family encodes a set of transcription factors and is defined by the presence of highly conserved do......

SOX17 in cellular reprogramming and cancer

期刊: SEMINARS IN CANCER BIOLOGY, 2020; 67 ()

SOX17 is a transcription factor directing the specification and development of the primitive endoderm, primitive germ cells, definitive endoderm and, ......

Novel role of sex-determining region Y-box 7 (SOX7) in tumor biology and cardiovascular developmental biology

期刊: SEMINARS IN CANCER BIOLOGY, 2020; 67 ()

The sex-determining region Y-box 7 (Sox7) is an important member of the SOX F family, which is characterized by a high-mobility-group DNA-binding doma......

Diverse pathogenetic roles of SOX genes in acute myeloid leukaemia and their therapeutic implications

期刊: SEMINARS IN CANCER BIOLOGY, 2020; 67 ()

Acute myeloid leukaemia (AML) is a heterogeneous group of diseases with diverse pathogenetic pathways. When treated uniformly with conventional chemot......

Tumor intrinsic and extrinsic immune functions of CD155

期刊: SEMINARS IN CANCER BIOLOGY, 2020; 65 ()

CD155 (PVR/necl5/Tage4), a member of the nectin-like family of adhesion molecules, is highly upregulated on tumor cells across multiple cancer types a......

Recent insights into apoptosis and toxic autophagy: The roles of MDA-7/IL-24, a multidimensional anti-cancer therapeutic

期刊: SEMINARS IN CANCER BIOLOGY, 2020; 66 ()

Apoptosis and autophagy play seminal roles in maintaining organ homeostasis. Apoptosis represents canonical type I programmed cell death. Autophagy is......

Ferroptosis is a type of autophagy-dependent cell death

期刊: SEMINARS IN CANCER BIOLOGY, 2020; 66 ()

Macroautophagy (hereafter referred to as autophagy) involves an intracellular degradation and recycling system that, in a context-dependent manner, ca......

Autoimmune diseases and hematological malignancies: Exploring the underlying mechanisms from epidemiological evidence

期刊: SEMINARS IN CANCER BIOLOGY, 2020; 64 ()

Autoimmune diseases are characterized by the irregular functioning of the immune system that leads to the loss of tolerance to self-antigens. The unde......

MicroRNA control of B cell tolerance, autoimmunity and cancer

期刊: SEMINARS IN CANCER BIOLOGY, 2020; 64 ()

Since the discovery of the first microRNA (miRNA) in 1993, thousands of miRNAs have been identified in humans and mice and many of them have been show......

PROTACs: A novel strategy for cancer therapy

期刊: SEMINARS IN CANCER BIOLOGY, 2020; 67 ()

Chemotherapeutic strategy has been widely used for treating malignance by targeting irregular expressed or mutant proteins with small molecular inhibi......

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