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Acetylcholinesterase inhibition protects against trastuzumab-induced cardiotoxicity through reducing multiple programmed cell death pathways

期刊： MOLECULAR MEDICINE, 2023; 29 (1)

BackgroundTrastuzumab (Trz)-induced cardiotoxicity (TIC) is one of the most common adverse effects of targeted anticancer agents. Although oxidative s......

Alteration in branching morphogenesis via YAP/TAZ in fibroblasts of fetal lungs in an LPS-induced inflammation model

期刊： MOLECULAR MEDICINE, 2023; 29 (1)

BackgroundChorioamnionitis is a common cause of preterm birth and leads to serious complications in newborns. The objective of this study was to inves......

Loss of Krüppel-like factor-10 facilitates the development of chemical-induced liver cancer in mice

期刊： MOLECULAR MEDICINE, 2023; 29 (1)

Background Kr & uuml;ppel-like factor 10 (KLF10) is involved in a positive feedback loop that regulates transforming growth factor beta (TGF beta)......

Gene expression variability in long-term survivors of childhood cancer and cancer-free controls in response to ionizing irradiation

期刊： MOLECULAR MEDICINE, 2023; 29 (1)

BackgroundDifferential expression analysis is usually adjusted for variation. However, most studies that examined the expression variability (EV) have......

Cryopreserved placental biopsies maintain mitochondrial activity for high-resolution respirometry

期刊： MOLECULAR MEDICINE, 2023; 29 (1)

Background High-resolution respirometry (HRR) of human biopsies can provide useful metabolic, diagnostic, and mechanistic insights for clinical resear......

B-vitamins, related vitamers, and metabolites in patients with quiescent inflammatory bowel disease and chronic fatigue treated with high dose oral thiamine

期刊： MOLECULAR MEDICINE, 2023; 29 (1)

BackgroundHigh doses of oral thiamine improve clinical fatigue scores in patients with quiescent inflammatory bowel disease (IBD) and chronic fatigue.......

Node-negative colon cancer: histological, molecular, and stromal features predicting disease recurrence

期刊： MOLECULAR MEDICINE, 2023; 29 (1)

BackgroundWithin the group of node-negative colon cancer patients, presumed to have a good prognosis, a significant percentage of patients develops ca......

Sufficient Cav-1 levels in the endothelium are critical for the maintenance of the neurovascular unit in the retina

期刊： MOLECULAR MEDICINE, 2023; 29 (1)

BackgroundCaveolin-1 (Cav-1) is a pivotal protein in the plasma membrane. Studies on homozygous Cav-1 deficient mice revealed that Cav-1 is essential ......

The alpha-synuclein oligomers activate nuclear factor of activated T-cell (NFAT) modulating synaptic homeostasis and apoptosis

期刊： MOLECULAR MEDICINE, 2023; 29 (1)

BackgroundSoluble oligomeric forms of alpha-synuclein (aSyn-O) are believed to be one of the main toxic species in Parkinson's disease (PD) leading to......

The pre-conception maternal exposure to Sofosbuvir affects the mitochondrial biogenesis in prenatal fetal tissues: Experimental study on rats

期刊： MOLECULAR MEDICINE, 2023; 29 (1)

Background Hepatitis C virus (HCV) infection is a global public health problem and Egypt has the highest HCV prevalence worldwide. Hence, global effor......

Autophagy and autophagy signaling in Epilepsy: possible role of autophagy activator

期刊： MOLECULAR MEDICINE, 2023; 29 (1)

Autophagy is an explicit cellular process to deliver dissimilar cytoplasmic misfolded proteins, lipids and damaged organelles to the lysosomes for deg......

Organ and cell-specific biomarkers of Long-COVID identified with targeted proteomics and machine learning

期刊： MOLECULAR MEDICINE, 2023; 29 (1)

BackgroundSurvivors of acute COVID-19 often suffer prolonged, diffuse symptoms post-infection, referred to as Long-COVID. A lack of Long-COVID biomark......

Glycyrrhizin, an inhibitor of HMGB1 induces autolysosomal degradation function and inhibits Helicobacter pylori infection

期刊： MOLECULAR MEDICINE, 2023; 29 (1)

BackgroundHelicobacter pylori is a key agent for causing gastric complications linked with gastric disorders. In response to infection, host cells sti......

Regulation of sexually dimorphic placental adaptation in LPS exposure-induced intrauterine growth restriction

期刊： MOLECULAR MEDICINE, 2023; 29 (1)

BackgroundSexual dimorphism in placental physiology affects the functionality of placental adaptation during adverse pregnancy. Defects of placental f......

Role of DCLK1/Hippo pathway in type II alveolar epithelial cells differentiation in acute respiratory distress syndrome

期刊： MOLECULAR MEDICINE, 2023; 29 (1)

BackgroundDelay in type II alveolar epithelial cell (AECII) regeneration has been linked to higher mortality in patients with acute respiratory distre......

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