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IL-6-induced cGGNBP2 encodes a protein to promote cell growth and metastasis in intrahepatic cholangiocarcinoma

期刊: HEPATOLOGY, 2022; 75 (6)

Background and Aims IL-6-induced tumor progression has been well established through the induction of antiapoptotic and proliferative genes. However, ......

JIF:9.037

A conventional immune regulator mitochondrial antiviral signaling protein blocks hepatic steatosis by maintaining mitochondrial homeostasis

期刊: HEPATOLOGY, 2022; 75 (2)

Background and Aims Although the prevalence of NAFLD has risen dramatically to 25% of the adult population worldwide, there are as yet no approved pha......

JIF:9.037

Dedifferentiation-associated inflammatory factors of long-term expanded human hepatocytes exacerbate their elimination by macrophages during liver engraftment

期刊: HEPATOLOGY, 2022; 76 (6)

Background and Aims Hepatocyte transplantation has been demonstrated to be effective to treat liver metabolic disease and acute liver failure. Neverth......

JIF:9.037

Aging exaggerates acute-on-chronic alcohol-induced liver injury in mice and humans by inhibiting neutrophilic sirtuin 1-C/EBP alpha-miRNA-223 axis

期刊: HEPATOLOGY, 2022; 75 (3)

Background and Aims Aging exacerbates liver neutrophil infiltration and alcohol-associated liver disease (ALD) in mice and humans, but the underlying ......

JIF:9.037

FGF4 protects the liver from nonalcoholic fatty liver disease by activating the AMP-activated protein kinase-Caspase 6 signal axis

期刊: HEPATOLOGY, 2022; 76 (4)

Background and Aims NAFLD represents an increasing health problem in association with obesity and diabetes with no effective pharmacotherapies. Growin......

JIF:9.037

HBV covalently closed circular DNA minichromosomes in distinct epigenetic transcriptional states differ in their vulnerability to damage

期刊: HEPATOLOGY, 2022; 75 (5)

Background and Aims HBV covalently closed circular DNA (cccDNA) is a major obstacle for a cure of chronic hepatitis B. Accumulating evidence suggests ......

JIF:9.037

Concurrent large spontaneous portosystemic shunt embolization for the prevention of overt hepatic encephalopathy after TIPS: A randomized controlled trial

期刊: HEPATOLOGY, 2022; 76 (3)

Background and Aims Large spontaneous portosystemic shunt (SPSS) is associated with increased risk of HE in patients undergoing transjugular intrahepa......

JIF:9.037

Shear stress-induced cellular senescence blunts liver regeneration through Notch-sirtuin 1-P21/P16 axis

期刊: HEPATOLOGY, 2022; 75 (3)

Background and Aims The mechanisms involved in liver regeneration after partial hepatectomy (pHx) are complicated. Cellular senescence, once linked to......

JIF:9.037

Notch-triggered maladaptation of liver sinusoidal endothelium aggravates nonalcoholic steatohepatitis through endothelial nitric oxide synthase

期刊: HEPATOLOGY, 2022; 76 (3)

Background and Aims Although NASH can lead to severe clinical consequences, including cirrhosis and hepatocellular carcinoma, no effective treatment i......

JIF:9.037

ATP7B gene therapy of autologous reprogrammed hepatocytes alleviates copper accumulation in a mouse model of Wilson's disease

期刊: HEPATOLOGY, 2022; 76 (4)

Background and Aims Wilson's disease (WD) is a rare hereditary disorder due to ATP7B gene mutation, causing pathologic copper storage mainly in the li......

JIF:9.037

Therapeutic targeting of hepatic ACSL4 ameliorates NASH in mice

期刊: HEPATOLOGY, 2022; 75 (1)

Background and Aims Globally, NAFLD is one of the most common liver disorders, with an estimated prevalence rate of more than 30% in men and 15% in wo......

JIF:9.037

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