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Epidural Anesthesia-Analgesia and Recurrencefree Survival after Lung Cancer Surgery: A Randomized Trial

期刊: ANESTHESIOLOGY, 2021; 135 (3)

Background: Regional anesthesia and analgesia reduce the stress response to surgery and decrease the need for volatile anesthesia and opioids, thereby......

Supplemental Intraoperative Oxygen and Long-term Mortality

期刊: ANESTHESIOLOGY, 2021; 134 (5)

Background: Vihether supplemental oxygen worsens long-term mortality remains unclear, with contradictory trial results. The authors therefore tested t......

Delirium in Older Patients after Combined Epidural-General Anesthesia or General Anesthesia for Major Surgery: A Randomized Trial

期刊: ANESTHESIOLOGY, 2021; 135 (2)

Background: Delirium is a common and serious postoperative complication, especially in the elderly. Epidural anesthesia may reduce delirium by improvi......

Intravenous versus Volatile Anesthetic Effects on Postoperative Cognition in Elderly Patients Undergoing Laparoscopic Abdominal Surgery A Multicenter, Randomized Trial

期刊: ANESTHESIOLOGY, 2021; 134 (3)

Background: Delayed neurocognitive recovery after surgery is associated with poor outcome. Most surgeries require general anesthesia, of which sevoflu......

Positive Regulatory Domain I-binding Factor 1 Mediates Peripheral Nerve Injury-induced Nociception in Mice by Repressing Kv4.3 Channel Expression

期刊: ANESTHESIOLOGY, 2021; 134 (3)

Background: The transcriptional repressor positive regulatory domain I-binding factor 1 (PRDM1) is expressed in adult mouse dorsal root ganglion and r......

Emergency Airway Management in Patients with COVID-19: A Prospective International Multicenter Cohort Study

期刊: ANESTHESIOLOGY, 2021; 135 (2)

Background: Tracheal intubation for patients with COVID-19 is required for invasive mechanical ventilation. The authors sought to describe practice fo......

Isoflurane Suppresses Hippocampal High-frequency Ripples by Differentially Modulating Pyramidal Neurons and Interneurons in Mice

期刊: ANESTHESIOLOGY, 2021; 135 (1)

Background: Isoflurane can induce anterograde amnesia. Hippocampal ripples are high-frequency oscillatory events occurring in the local field potentia......

Burnout Rate and Risk Factors among Anesthesiologists in the United States

期刊: ANESTHESIOLOGY, 2021; 134 (5)

Background: Physician burnout, widespread across medicine, is linked to poorer physician quality of life and reduced quality of care. Data on prevalen......

GABAergic Neurons in the Dorsal-Intermediate Lateral Septum Regulate Sleep-Wakefulness and Anesthesia in Mice

期刊: ANESTHESIOLOGY, 2021; 135 (3)

Background: The.-aminobutyric acid-mediated (GABAergic) inhibitory system in the brain is critical for regulation of sleep-wake and general anesthesia......

Long-term Survival after Combined Epidural-General Anesthesia or General Anesthesia Alone: Follow-up of a Randomized Trial

期刊: ANESTHESIOLOGY, 2021; 135 (2)

Background: Experimental and observational research suggests that combined epidural-general anesthesia may improve long-term survival after cancer sur......

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