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Renal Klotho safeguards platelet lifespan in advanced chronic kidney disease through restraining Bcl-xL ubiquitination and degradation

期刊: JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2022; 20 (12)

Background Thrombosis and hemorrhage as two opposite pathologies are prevalent within the chronic kidney disease (CKD) population. Platelet homeostasi......

JIF:3.961

XJ-8, a natural compound isolated from Sanguis draxonis, inhibits platelet function and thrombosis by targeting MAP3K3

期刊: JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2022; 20 (3)

Background Vascular injury initiates rapid platelet activation, which is critical for haemostasis, while it also causes fatal thrombotic diseases, suc......

JIF:3.961

Bifunctional effect of the inflammatory cytokine tumor necrosis factor alpha on megakaryopoiesis and platelet production

期刊: JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2022; 20 (12)

Background and Objectives: Platelets are affected by many factors, such as infectious or aseptic inflammation, and different inflammatory states may i......

JIF:3.961

Structural and cellular basis of vitamin K antagonism

期刊: JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2022; 20 (9)

Vitamin K antagonists (VKAs), such as warfarin, are oral anticoagulants widely used to treat and prevent thromboembolic diseases. Therapeutic use of t......

JIF:3.961

Dose tapering to withdrawal stage and long-term efficacy and safety of hetrombopag for the treatment of immune thrombocytopenia: Results from an open-label extension study

期刊: JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2022; 20 (3)

Background The efficacy of hetrombopag in Chinese patients with immune thrombocytopenia (ITP) has been demonstrated in a randomized, double-blind, pla......

JIF:3.961

Generation of a thrombopoietin-deficient thrombocytopenia model in zebrafish

期刊: JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2022; 20 (8)

Background The production of platelets is tightly regulated by thrombopoietin (THPO). Mutations in the THPO gene cause thrombocytopenia. Although mice......

JIF:3.961

Tissue dynamics of von Willebrand factor characterized by a novel fluorescent protein-von Willebrand factor chimera

期刊: JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2022; 20 (1)

Background Tissue dynamics of von Willebrand factor (VWF) that are vital to its biological function have not been fully characterized. Objective To de......

JIF:3.961

Discovery of plasma biomarkers with data-independent acquisition mass spectrometry and antibody microarray for diagnosis and risk stratification of pulmonary embolism

期刊: JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2021; 19 (7)

Background Pulmonary embolism (PE) is a leading cause of cardiovascular mortality worldwide. Rapid and accurate diagnosis and risk stratification are ......

Photobiomodulation therapy for thrombocytopenia by upregulating thrombopoietin expression via the ROS-dependent Src/ERK/STAT3 signaling pathway

期刊: JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2021; 19 (8)

Background Chemotherapy-induced thrombocytopenia (CIT) can increase the risk of bleeding, which may delay or prevent the administration of anticancer ......

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