筛选条件 共查询到56条结果
排序方式
Impacts of CYP2C19 genetic polymorphisms on bioavailability and effect on platelet adhesion of vicagrel, a novel thienopyridine P2Y(12)inhibitor

期刊: BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2020; 86 (9)

Aims We investigated the impacts of CYP2C19 polymorphisms on pharmacokinetics and pharmacodynamics of vicagrel in healthy Chinese subjects. Methods CY......

Quality of clinical direct oral anticoagulant prescribing and identification of risk factors for inappropriate prescriptions

期刊: BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2020; 86 (8)

Aims Even though the use of direct oral anticoagulants (DOACs) is safe based on clinical outcomes, drug safety also depends on appropriateness of drug......

Effect of postdose fasting duration on hetrombopag olamine pharmacokinetics and pharmacodynamics in healthy volunteers

期刊: BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2020; 86 (8)

Aims Hetrombopag olamine is a novel small-molecule, nonpeptide thrombopoietin receptor agonist developed for immune thrombocytopenia treatment. This s......

Comparison of pharmacokinetics, safety and tolerability of secukinumab administered subcutaneously using different delivery systems in healthy volunteers and in psoriasis patients

期刊: BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2020; 86 (2)

Aims The aim of the study was to compare the pharmacokinetics (PK), safety and tolerability of secukinumab with different devices for subcutaneous (s.......

The effectiveness and safety of topical beta-receptor blocker in treating superficial infantile haemangiomas: A meta-analysis including 20 studies

期刊: BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2020; 86 (2)

Aims To evaluate the effectiveness and safety of topical beta-receptor blocker in treating superficial infantile haemangiomas (SIH) and compare the ef......

Off-label use of tacrolimus in children with glomerular disease: Effectiveness, safety and pharmacokinetics

期刊: BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2020; 86 (2)

Glomerular diseases are leading causes of end-stage renal disease in children. Tacrolimus is frequently used off-label in the treatment of glomerular ......

The efficacy and safety of fingolimod in patients with relapsing multiple sclerosis: A meta-analysis

期刊: BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2020; 86 (4)

Aims The aim of the present meta-analysis was to evaluate the efficacy and safety of fingolimod in patients with relapsing multiple sclerosis (RMS). M......

Precision therapy of 6-mercaptopurine in Chinese children with acute lymphoblastic leukaemia

期刊: BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2020; 86 (8)

Aims Chinese children are more susceptible to the development of thiopurine-induced leukopenia compared with Caucasian populations. The aim of our stu......

A systematic review and combined meta-analysis of concentration of oral amisulpride

期刊: BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2020; 86 (4)

Aims Amisulpride, a first-line schizophrenia treatment, has shown large interindividual variability in plasma/serum levels, often outside the referenc......

Risk of major bleeding among users of direct oral anticoagulants combined with interacting drugs: A population-based nested case-control study

期刊: BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2020; 86 (6)

Aims To assess the association between concurrent use of potential pharmacokinetic or pharmacodynamic interacting drugs and major bleeding among direc......

Exploration of suitable pharmacodynamic parameters for acarbose bioequivalence evaluation: A series of clinical trials with branded acarbose

期刊: BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2020; 86 (11)

Aims To determine deficiencies in the Food and Drug Administration (FDA)'s guidance for assessing acarbose bioequivalence (BE) and to explore optimal ......

共56条页码: 1/4页15条/页
打开APP