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Developing a physiologically based pharmacokinetic model of apixaban to predict scenarios of drug-drug interactions, renal impairment and paediatric populations

期刊: BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2021; 87 (8)

Aims: To develop a physiologically based pharmacokinetic (PBPK) model for apixaban, an oral anticoagulant with a narrow therapeutic index, and to pred......

Population pharmacokinetics and exposure-response analysis of tigecycline in patients with hospital-acquired pneumonia

期刊: BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2021; 87 (7)

Background Tigecycline has been widely used to treat hospital-acquired pneumonia (HAP) off-label since it is effective against a wide range of multidr......

Modelling item scores of Unified Parkinson's Disease Rating Scale Part III for greater trial efficiency

期刊: BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2021; 87 (9)

Aims The multipart Unified Parkinson's Disease Rating Scale is the standard instrument in clinical trials. A sum of scores for all items in 1 or more ......

Development of a physiologically based pharmacokinetic (PBPK) population model for Chinese elderly subjects

期刊: BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2021; 87 (7)

Aims This study aims to develop and verify a physiologically based pharmacokinetic (PBPK) population model for the Chinese geriatric population in Sim......

Improved estimates of mean pharmacokinetic parameters for increased accuracy in dosing and reduced risk to patients

期刊: BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, ; ()

Aims Pharmacokinetic equations, which relate different parameters of a single individual, are often applied to reported mean parameter-values, with th......

Off-label use of letrozole in Chinese short pubertal boys: Effectiveness, safety, and exposure-response analysis

期刊: BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, ; ()

Aims Recently, letrozole has been used off-label to treat short pubertal boys. The experience on letrozole effectiveness and safety has been obtained ......

External evaluation of the predictive performance of seven population pharmacokinetic models for phenobarbital in neonates

期刊: BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, ; ()

Aim Several studies have reported population pharmacokinetic models for phenobarbital (PB), but the predictive performance of these models has not bee......

Impact of pharmacist-led medication therapy management in ambulatory elderly patients with chronic diseases

期刊: BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, ; ()

Aims This study aimed to assess the impact of pharmacist-led medication therapy management (MTM) performed on ambulatory elderly patients with chronic......

Pharmacokinetics and safety of pegylated recombinant human granulocyte colony-stimulating factor in children with acute leukaemia

期刊: BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, ; ()

Aims This open-label, phase I study evaluated the pharmacokinetics and safety of pegylated recombinant human granulocyte colony-stimulating factor (PE......

Impacts of CYP2C19 genetic polymorphisms on bioavailability and effect on platelet adhesion of vicagrel, a novel thienopyridine P2Y(12)inhibitor

期刊: BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2020; 86 (9)

Aims We investigated the impacts of CYP2C19 polymorphisms on pharmacokinetics and pharmacodynamics of vicagrel in healthy Chinese subjects. Methods CY......

Quality of clinical direct oral anticoagulant prescribing and identification of risk factors for inappropriate prescriptions

期刊: BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2020; 86 (8)

Aims Even though the use of direct oral anticoagulants (DOACs) is safe based on clinical outcomes, drug safety also depends on appropriateness of drug......

Effect of postdose fasting duration on hetrombopag olamine pharmacokinetics and pharmacodynamics in healthy volunteers

期刊: BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2020; 86 (8)

Aims Hetrombopag olamine is a novel small-molecule, nonpeptide thrombopoietin receptor agonist developed for immune thrombocytopenia treatment. This s......

Comparison of pharmacokinetics, safety and tolerability of secukinumab administered subcutaneously using different delivery systems in healthy volunteers and in psoriasis patients

期刊: BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2020; 86 (2)

Aims The aim of the study was to compare the pharmacokinetics (PK), safety and tolerability of secukinumab with different devices for subcutaneous (s.......

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