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Structural analyses of the Group A flavin-dependent monooxygenase PieE reveal a sliding FAD cofactor conformation bridging OUT and IN conformations

期刊: JOURNAL OF BIOLOGICAL CHEMISTRY, 2020; 295 (14)

Group A flavin-dependent monooxygenases catalyze the cleavage of the oxygen?oxygen bond of dioxygen, followed by the incorporation of one oxygen atom ......

The E3 ubiquitin ligase STUB1 attenuates cell senescence by promoting the ubiquitination and degradation of the core circadian regulator BMAL1

期刊: JOURNAL OF BIOLOGICAL CHEMISTRY, 2020; 295 (14)

Cell senescence is one of the most important processes determining cell fate and is involved in many pathophysiological conditions, including cancer, ......

The transcription factor Sp1 modulates RNA polymerase III gene transcription by controlling BRF1 and GTF3C2 expression in human cells

期刊: JOURNAL OF BIOLOGICAL CHEMISTRY, 2020; 295 (14)

Specificity protein 1 (Sp1) is an important transcription factor implicated in numerous cellular processes. However, whether Sp1 is involved in the re......

Protein kinase A phosphorylation potentiates cystic fibrosis transmembrane conductance regulator gating by relieving autoinhibition on the stimulatory C terminus of the regulatory domain

期刊: JOURNAL OF BIOLOGICAL CHEMISTRY, 2020; 295 (14)

Cystic fibrosis transmembrane conductance regulator (CFTR) is a chloride channel activated by protein kinase A (PKA) phosphorylation on the regulatory......

Autolysosomal degradation of cytosolic chromatin fragments antagonizes oxidative stress?induced senescence

期刊: JOURNAL OF BIOLOGICAL CHEMISTRY, 2020; 295 (14)

Oxidative stress-induced DNA damage, the senescence-associated secretory phenotype (SASP), and impaired autophagy all are general features of senescen......

The structural features that distinguish PD-L2 from PD-L1 emerged in placental mammals

期刊: JOURNAL OF BIOLOGICAL CHEMISTRY, 2020; 295 (14)

Programmed cell death protein 1 (PD-1) is an inhibitory receptor on T lymphocytes that is critical for modulating adaptive immunity. As such, it has b......

The balance of protein farnesylation and geranylgeranylation during the progression of nonalcoholic fatty liver disease

期刊: JOURNAL OF BIOLOGICAL CHEMISTRY, 2020; 295 (15)

Protein prenylation is an essential posttranslational modification and includes protein farnesylation and geranylgeranylation using farnesyl diphospha......

A recently evolved diflavin-containing monomeric nitrate reductase is responsible for highly efficient bacterial nitrate assimilation

期刊: JOURNAL OF BIOLOGICAL CHEMISTRY, 2020; 295 (15)

Nitrate is one of the major inorganic nitrogen sources for microbes. Many bacterial and archaeal lineages have the capacity to express assimilatory ni......

Biochemical characterization of acyl activating enzymes for side chain moieties of Taxol and its analogs

期刊: JOURNAL OF BIOLOGICAL CHEMISTRY, 2020; 295 (15)

Taxol (paclitaxel) is a very widely used anticancer drug, but its commercial sources mainly consist of stripped bark or suspension cultures of members......

Paraoxonase 3 functions as a chaperone to decrease functional expression of the epithelial sodium channel

期刊: JOURNAL OF BIOLOGICAL CHEMISTRY, 2020; 295 (15)

The paraoxonase (PON) family comprises three highly conserved members: PON1, PON2, and PON3. They are orthologs of Caenorhabditis elegans MEC-6, an en......

The long noncoding RNA MyHC IIA/X-AS contributes to skeletal muscle myogenesis and maintains the fast fiber phenotype

期刊: JOURNAL OF BIOLOGICAL CHEMISTRY, 2020; 295 (15)

Mammalian skeletal muscles comprise different types of muscle fibers, and this muscle fiber heterogeneity is generally characterized by the expression......

Biosynthesis of depsipeptides with a 3-hydroxybenzoate moiety and selective anticancer activities involves a chorismatase

期刊: JOURNAL OF BIOLOGICAL CHEMISTRY, 2020; 295 (16)

Neoantimycins are anticancer compounds of 15-membered ring antimycin-type depsipeptides. They are biosynthesized by a hybrid multimodular protein comp......

The transcriptional regulator MEIS2 sets up the ground state for palatal osteogenesis in mice

期刊: JOURNAL OF BIOLOGICAL CHEMISTRY, 2020; 295 (16)

Haploinsufficiency of Meis homeobox 2 (MEIS2), encoding a transcriptional regulator, is associated with human cleft palate, and Meis2 inactivation lea......

Proline-rich 11 (PRR11) drives F-actin assembly by recruiting the actin-related protein 2/3 complex in human non-small cell lung carcinoma

期刊: JOURNAL OF BIOLOGICAL CHEMISTRY, 2020; 295 (16)

The actin cytoskeleton is extremely dynamic and supports diverse cellular functions in many physiological and pathological processes, including tumori......

Structures of the MHC-I molecule BF2*1501 disclose the preferred presentation of an H5N1 virus-derived epitope

期刊: JOURNAL OF BIOLOGICAL CHEMISTRY, 2020; 295 (16)

Lethal infections by strains of the highly-pathogenic avian influenza virus (HPAIV) H5N1 pose serious threats to both the poultry industry and public ......

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