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Mesenchymal stromal cell therapy for pancreatitis: Progress and challenges

期刊: MEDICINAL RESEARCH REVIEWS, 2021; 41 (4)

Pancreatitis is a common gastrointestinal disease with no effective therapeutic options, particularly for cases of severe acute and chronic pancreatit......

Pharmaceuticals targeting signaling pathways of endometriosis as potential new medical treatment: A review

期刊: MEDICINAL RESEARCH REVIEWS, 2021; 41 (4)

Endometriosis (EM) is defined as endometrial tissues found outside the uterus. Growth and development of endometriotic cells in ectopic sites can be p......

Recent progresses and remaining challenges for the detection of Zika virus

期刊: MEDICINAL RESEARCH REVIEWS, 2021; 41 (4)

Zika virus (ZIKV) has emerged as a particularly notorious mosquito-borne flavivirus, which can lead to a devastating congenital syndrome in the fetuse......

Recent advances in proteome-wide label-free target deconvolution for bioactive small molecules

期刊: MEDICINAL RESEARCH REVIEWS, ; ()

Small-molecule drugs modulate biological processes and disease states through engagement of target proteins in cells. Assessing drug-target engagement......

The Yin and Yang of traditional Chinese and Western medicine

期刊: MEDICINAL RESEARCH REVIEWS, ; ()

The success of Western Scientific approaches to medicine, over the last 150 years, can be measured by substantial increases in life expectancy, reduct......

Peroral targeting of drug micro or nanocarriers to sites beyond the gastrointestinal tract

期刊: MEDICINAL RESEARCH REVIEWS, ; ()

Targeted delivery of drug micro or nanocarriers has been attained via parenteral routes, especially the intravenous route. Conventionally, oral target......

MALT1 as a promising target to treat lymphoma and other diseases related to MALT1 anomalies

期刊: MEDICINAL RESEARCH REVIEWS, ; ()

Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) is a key adaptor protein that regulates the NF-kappa B pathway, in which MA......

What coronavirus 3C-like protease tells us: From structure, substrate selectivity, to inhibitor design

期刊: MEDICINAL RESEARCH REVIEWS, ; ()

The emergence of a variety of coronaviruses (CoVs) in the last decades has posed huge threats to human health. Especially, the ongoing pandemic of cor......

Phytochemistry and cardiovascular protective effects of Huang-Qi (Astragali Radix)

期刊: MEDICINAL RESEARCH REVIEWS, ; ()

Huang-Qi (Astragali Radix) is an herbal tonic widely used in China and many other countries. It is derived from the roots of Astragalus membranaceus a......

Ribosome-targeting antibacterial agents: Advances, challenges, and opportunities

期刊: MEDICINAL RESEARCH REVIEWS, ; ()

Ribosomes, which synthesize proteins, are critical organelles for the survival and growth of bacteria. About 60% of approved antibiotics discovered so......

Emerging roles of microRNA-208a in cardiology and reverse cardio-oncology

期刊: MEDICINAL RESEARCH REVIEWS, ; ()

Cardiovascular diseases (CVDs) and cancer, which are the leading causes of mortality globally, have been viewed as two distinct diseases. However, the......

Exploring and exploiting plant cyclic peptides for drug discovery and development

期刊: MEDICINAL RESEARCH REVIEWS, ; ()

Ever since the discovery of insulin, natural peptides have become an important resource for therapeutic development. Decades of research has led to th......

Therapeutic targets and potential agents for the treatment of COVID-19

期刊: MEDICINAL RESEARCH REVIEWS, 2021; 41 (3)

The outbreak of coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, has be......

Druggability modification strategies of the diarylpyrimidine-type non-nucleoside reverse transcriptase inhibitors

期刊: MEDICINAL RESEARCH REVIEWS, 2021; 41 (3)

Drug discovery of human immunodeficiency virus (HIV) is a hot field in medicinal chemistry community for many years. The diarylpyrimidines (DAPYs) are......

Cardiac efficacy and toxicity of aconitine: A new frontier for the ancient poison

期刊: MEDICINAL RESEARCH REVIEWS, 2021; 41 (3)

Aconitine (AC) is well-known as the main toxic ingredient and active compound of Aconitum species, of which several aconites are essential herbal medi......

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