期刊： NATURE METABOLISM, 2022; 4 (9)
Combined use of cannabis and alcohol results in greater psychoactive toxicity than either substance alone, but the underlying central mechanisms behin......
期刊： NATURE METABOLISM, 2022; 4 (9)
The tyrosine kinase receptor EphB4 is shown to interact with the insulin receptor to facilitate its endocytosis and degradation, thereby decreasing in......
期刊： NATURE METABOLISM, 2022; 4 (2)
Mutant p53 protein is stabilized by direct binding to 2-HG produced by malic enzyme 2, resulting in enhanced tumour growth. Many types of cancer featu......
期刊： NATURE METABOLISM, 2022; 4 (3)
Tumour cells utilize multiple strategies to evade the immune system, but the underlying metabolic mechanisms remain poorly understood. The pyruvate de......
期刊： NATURE METABOLISM, 2022; 4 (10)
Microglial cells consume adenosine triphosphate (ATP) during phagocytosis to clear neurotoxic beta-amyloid in Alzheimer's disease (AD). However, the c......
期刊： NATURE METABOLISM, 2022; 4 (10)
Qiao et al. reveal that a Ganoderma meroterpene derivative can prevent atherosclerosis by increasing the abundance of Parabacteroides merdae in the gu......
期刊： NATURE METABOLISM, 2022; 4 (8)
Alterations in cholesterol homeostasis may contribute to hepatic cancer aggressiveness. Liu, Tian, and Zhang et al. identify the long non-coding RNA S......
期刊： NATURE METABOLISM, 2022; 4 (2)
Tumors can reprogram the functions of metabolic enzymes to fuel malignant growth; however, beyond their conventional functions, key metabolic enzymes ......
期刊： NATURE METABOLISM, 2022; 4 (7)
Methanol is an ideal feedstock for biomanufacturing that can be beneficial for global carbon neutrality; however, the toxicity of methanol limits the ......
期刊： NATURE METABOLISM, 2022; 4 (10)
A small-molecule aldolase inhibitor, aldolazin is reported and shown to selectively activate the lysosomal pool of AMPK, which has glucose-lowering ef......
期刊： NATURE METABOLISM, 2022; 4 (1)
Severe cases of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are associated with elevated blood glucose levels and meta......
期刊： NATURE METABOLISM, 2022; 4 (1)
Ma et al. show that acetylation of PRDM16 via acetyl-CoA, derived from branched-chain keto acids, impairs PRDM16-PPAR interaction, thus linking the BC......
期刊： NATURE METABOLISM, 2022; 4 (8)
Aberrant RNA modifications lead to dysregulated gene expression and cancer progression. Ribosomal RNA (rRNA) accounts for more than 80% of a cell's to......
期刊： NATURE METABOLISM, 2022; 4 (10)
Guo et al. show that Cdo1, a taurine-synthesis enzyme, interacts with PPAR gamma to promote its transactivation of genes encoding the lipases ATGL and......
