筛选条件 共查询到140条结果
排序方式
Systems Biology Integration and Screening of Reliable Prognostic Markers to Create Synergies in the Control of Lung Cancer Patients

期刊: FRONTIERS IN MOLECULAR BIOSCIENCES, 2020; 7 ()

This study aims to achieve a clearer and stronger understanding of all the mechanisms involved in the occurrence as well as in the progression of lung......

Gibbs Free Energy Calculation of Mutation in PncA and RpsA Associated With Pyrazinamide Resistance

期刊: FRONTIERS IN MOLECULAR BIOSCIENCES, 2020; 7 ()

A central approach for better understanding the forces involved in maintaining protein structures is to investigate the protein folding and thermodyna......

Molecular Mechanism of Selective Binding of NMS-P118 to PARP-1 and PARP-2: A Computational Perspective

期刊: FRONTIERS IN MOLECULAR BIOSCIENCES, 2020; 7 ()

The nuclear protein poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors have been proven effective to potentiate both chemotherapeutic agents and radio......

Understanding Thermostability Factors of Barley Limit Dextrinase by Molecular Dynamics Simulations

期刊: FRONTIERS IN MOLECULAR BIOSCIENCES, 2020; 7 ()

Limit dextrinase (LD) is the only endogenous starch-debranching enzyme in barley (Hordeum vulgare, Hv), which is the key factor affecting the producti......

Deubiquitinase Inhibitor b-AP15 Attenuated LPS-Induced Inflammation via Inhibiting ERK1/2, JNK, and NF-Kappa B

期刊: FRONTIERS IN MOLECULAR BIOSCIENCES, 2020; 7 ()

b-AP15 is a deubiquitinase (DUB) inhibitor of 19S proteasomes, which in turn targets ubiquitin C-terminal hydrolase 5 (UCHL5) and ubiquitin-specific p......

Intrinsic Genetic and Transcriptomic Patterns Reflect Tumor Immune Subtypes Facilitating Exploring Possible Combinatory Therapy

期刊: FRONTIERS IN MOLECULAR BIOSCIENCES, 2020; 7 ()

The classification of immune subtypes was based on immune signatures highlighting the tumor immuno-microenvironment. It was found that immune subtypes......

XRCC1 Is a Promising Predictive Biomarker and Facilitates Chemo-Resistance in Gallbladder Cancer

期刊: FRONTIERS IN MOLECULAR BIOSCIENCES, 2020; 7 ()

Gallbladder cancer is a relatively uncommon human malignant tumor with an extremely poor prognosis. Currently, no biomarkers can accurately diagnose g......

Cellular Plasticity in Breast Cancer Progression and Therapy

期刊: FRONTIERS IN MOLECULAR BIOSCIENCES, 2020; 7 ()

With the exception of non-melanoma skin cancer, breast cancer is the most frequently diagnosed malignant disease among women, with the majority of mor......

Clinical Significance of an m6A Reader Gene, IGF2BP2, in Head and Neck Squamous Cell Carcinoma

期刊: FRONTIERS IN MOLECULAR BIOSCIENCES, 2020; 7 ()

The importance of N6-methyladenosine (m6A) in tumor recurrence and prognosis has been recognized in recent years. The role of m6A readers, such as ins......

Molecular Mechanism of Mesenchyme Homeobox 1 in Transforming Growth Factor beta 1-Induced P311 Gene Transcription in Fibrosis

期刊: FRONTIERS IN MOLECULAR BIOSCIENCES, 2020; 7 ()

Organ fibrosis is characterized by excessive fibroblast, and extracellular matrix and the molecular basis are not fully elucidated. Recent studies hav......

B-Cell Receptor-Associated Protein 31 Negatively Regulates the Expression of Monoamine Oxidase A Via R1

期刊: FRONTIERS IN MOLECULAR BIOSCIENCES, 2020; 7 ()

B-cell receptor-associated protein 31 (Bap31) is a three trans-membrane protein of the endoplasmic reticulum (ER). Patients who have loss of function ......

Heat Shock Protein 60 in Cardiovascular Physiology and Diseases

期刊: FRONTIERS IN MOLECULAR BIOSCIENCES, 2020; 7 ()

Heat shock protein 60 (HSP60) is a highly conserved protein abundantly expressed in both prokaryotic and eukaryotic cells. In mammals, HSP60 has been ......

Characterization and Function of Circular RNAs in Plants

期刊: FRONTIERS IN MOLECULAR BIOSCIENCES, 2020; 7 ()

CircRNAs are covalently closed-loop single-stranded RNA molecules ubiquitously expressing in eukaryotes. As an important member of the endogenous ncRN......

Theoretical Exploring Selective-Binding Mechanisms of JAK3 by 3D-QSAR, Molecular Dynamics Simulation and Free Energy Calculation

期刊: FRONTIERS IN MOLECULAR BIOSCIENCES, 2020; 7 ()

Janus kinase 3 (JAK3) plays a critical role in the JAK/STAT signaling pathway and has become an attractive selective target for the treatment of immun......

Update in Laboratory Diagnosis of Thalassemia

期刊: FRONTIERS IN MOLECULAR BIOSCIENCES, 2020; 7 ()

Alpha- and beta-thalassemias and abnormal hemoglobin (Hb) are common in tropical countries. These abnormal globin genes in different combinations lead......

共140条页码: 1/10页15条/页