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The RAISE Trial: A Novel Device and First-in-Man Trial

期刊: CIRCULATION-HEART FAILURE, 2022; 15 (4)

BACKGROUND: Currently, standard medical therapies have limited effects on heart failure with preserved ejection fraction (HFpEF), which impacts on the......

JIF:4.69

Exercise Training Protects Against Heart Failure Via Expansion of Myeloid-Derived Suppressor Cells Through Regulating IL-10/STAT3/S100A9 Pathway

期刊: CIRCULATION-HEART FAILURE, 2022; 15 (3)

Background: Exercise training (ET) has a protective effect on the progression of heart failure, however, the specific mechanism has not been fully exp......

JIF:4.69

Association of Lifestyle With Incidence of Heart Failure According to Metabolic and Genetic Risk Status: A Population-Based Prospective Study

期刊: CIRCULATION-HEART FAILURE, 2022; 15 (9)

Background:Whether lifestyle factors are similarly associated with risk of heart failure (HF) for individuals with different metabolic or genetic risk......

JIF:4.69

Global Differences in Heart Failure With Preserved Ejection Fraction The PARAGON-HF Trial

期刊: CIRCULATION-HEART FAILURE, 2021; 14 (4)

Background: Heart failure with preserved ejection fraction (HFpEF) is a global public health problem with important regional differences. We investiga......

Cardiolipin Remodeling Defects Impair Mitochondrial Architecture and Function in a Murine Model of Barth Syndrome Cardiomyopathy

期刊: CIRCULATION-HEART FAILURE, 2021; 14 (6)

Background: Cardiomyopathy is a major clinical feature in Barth syndrome (BTHS), an X-linked mitochondrial lipid disorder caused by mutations in Tafaz......

Myocardial Tissue Reverse Remodeling After Guideline-Directed Medical Therapy in Idiopathic Dilated Cardiomyopathy

期刊: CIRCULATION-HEART FAILURE, 2021; 14 (1)

BACKGROUND: The prognosis of patients with idiopathic dilated cardiomyopathy (DCM) has improved remarkably in recent decades with guideline-directed m......

Long Noncoding RNA Ahit Protects Against Cardiac Hypertrophy Through SUZ12 (Suppressor of Zeste 12 Protein Homolog)-Mediated Downregulation of MEF2A (Myocyte Enhancer Factor 2A)

期刊: CIRCULATION-HEART FAILURE, 2020; 13 (1)

BACKGROUND: Long noncoding RNA (lncRNA) can regulate various physiological and pathological processes through multiple molecular mechanisms in cis and......

Pharmacological Silencing of MicroRNA-152 Prevents Pressure Overload-Induced Heart Failure

期刊: CIRCULATION-HEART FAILURE, 2020; 13 (3)

Background: MicroRNAs are small, noncoding RNAs that play a key role in gene expression. Accumulating evidence suggests that aberrant microRNA express......

Nexilin Is Necessary for Maintaining the Transverse-Axial Tubular System in Adult Cardiomyocytes

期刊: CIRCULATION-HEART FAILURE, 2020; 13 (7)

Background: NEXN (nexilin) is a protein of the junctional membrane complex required for development of cardiac T-tubules. Global and cardiomyocyte-spe......

COP9 Signalosome Suppresses RIPK1-RIPK3-Mediated Cardiomyocyte Necroptosis in Mice

期刊: CIRCULATION-HEART FAILURE, 2020; 13 (8)

BACKGROUND: Mechanisms governing the induction of heart failure by the impairment of autophagy and the ubiquitin-proteasome system and the molecular p......

Prognostic Value of Secreted Frizzled-Related Protein 5 in Heart Failure Patients With and Without Type 2 Diabetes Mellitus

期刊: CIRCULATION-HEART FAILURE, 2020; 13 (9)

Background: Patients with heart failure (HF) with diabetes mellitus have distinct biomarker profiles compared with those without diabetes mellitus. SF......

Referral Criteria to Palliative Care for Patients With Heart Failure A Systematic Review

期刊: CIRCULATION-HEART FAILURE, 2020; 13 (9)

Background: Patients with heart failure have significant symptom burden, care needs, and often a progressive course to end-stage disease. Palliative c......

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