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The Synergistic Anti-Tumor Activity of EZH2 Inhibitor SHR2554 and HDAC Inhibitor Chidamide through ORC1 Reduction of DNA Replication Process in Diffuse Large B Cell Lymphoma

期刊: CANCERS, 2021; 13 (17)

Simple Summary The EZH2-targeted drugs have demonstrated notable therapeutic effects in EZH2 mutant B-cell lymphoma patients. In this study, we demons......

Paliperidone Inhibits Glioblastoma Growth in Mouse Brain Tumor Model and Reduces PD-L1 Expression

期刊: CANCERS, 2021; 13 (17)

Simple Summary The present study showed that a prescribed psychotropic medicine paliperidone inhibits GBM growth and prolongs survival in mouse brain ......

Impact of Local Liver Irradiation Concurrent Versus Sequential with Lenvatinib on Pharmacokinetics and Biodistribution

期刊: CANCERS, 2021; 13 (7)

Simple Summary Lenvatinib is a systemic treatment for patients with advanced hepatocellular carcinoma (HCC). Stereotactic body radiation therapy (SBRT......

Percutaneous Irreversible Electroporation for Treatment of Small Hepatocellular Carcinoma Invisible on Unenhanced CT: A Novel Combined Strategy with Prior Transarterial Tumor Marking

期刊: CANCERS, 2021; 13 (9)

Simple Summary Irreversible electroporation (IRE) is an effective alternative for the ablation of small hepatocellular carcinoma (HCC) less than 2 cm,......

PBK/TOPK: An Effective Drug Target with Diverse Therapeutic Potential

期刊: CANCERS, 2021; 13 (9)

Simple Summary Cancer is a major public health problem worldwide, and addressing its morbidity, mortality, and prevalence is the first step towards ap......

Transcription Factor AP4 Mediates Cell Fate Decisions: To Divide, Age, or Die

期刊: CANCERS, 2021; 13 (4)

Simple Summary Here, we review the literature on Activating Enhancer-Binding Protein 4 (AP4)/transcription factor AP4 (TFAP4) function and regulation ......

Stereotactic Ablative Brachytherapy: Recent Advances in Optimization of Radiobiological Cancer Therapy

期刊: CANCERS, 2021; 13 (14)

Simple Summary Emerging studies involving ablative brachytherapy with curative effect have been published, but the evidence was not comprehensively di......

Correlation of Body Mass Index with Oncologic Outcomes in Colorectal Cancer Patients: A Large Population-Based Study

期刊: CANCERS, 2021; 13 (14)

Simple Summary Obesity is related to the rising risk of colorectal cancer (CRC). However, the impact of body mass index (BMI) on the oncologic prognos......

Identification of an RNA-Binding-Protein-Based Prognostic Model for Ewing Sarcoma

期刊: CANCERS, 2021; 13 (15)

Simple Summary Ewing sarcoma (ES) is an aggressive childhood tumor for which response to chemotherapy is central to long-term prognosis, but few progn......

A Prehepatectomy Circulating Exosomal microRNA Signature Predicts the Prognosis and Adjuvant Chemotherapeutic Benefits in Colorectal Liver Metastasis

期刊: CANCERS, 2021; 13 (17)

Simple Summary Exosomal miRNAs are associated with colorectal cancer liver metastasis (CRLM)-related biological behavior and prognosis. However, an ex......

Infant Acute Myeloid Leukemia: A Unique Clinical and Biological Entity

期刊: CANCERS, 2021; 13 (4)

Simple Summary Infant acute myeloid leukemia (AML) is a rare subgroup of AML of pediatric patients under two years of age. For a long time, they have ......

CALD1 Modulates Gliomas Progression via Facilitating Tumor Angiogenesis

期刊: CANCERS, 2021; 13 (11)

Simple Summary Caldesmon has recently attracted attention in cancer due to its roles in cell migration, invasion and proliferation. l-CALD1 was also c......

Tumor Microenvironment in Breast Cancer-Updates on Therapeutic Implications and Pathologic Assessment

期刊: CANCERS, 2021; 13 (16)

Simple Summary The tumor microenvironment (TME) in breast cancer plays important roles in tumor behavior and treatment response, making its pathologic......

Chimeric Antigen Receptor T-Cell Therapy: The Light of Day for Osteosarcoma

期刊: CANCERS, 2021; 13 (17)

Simple Summary As a novel immunotherapy, chimeric antigen receptor (CAR) T-cell therapy has achieved encouraging results in leukemia and lymphoma. Fur......

Immune Responses against Disseminated Tumor Cells

期刊: CANCERS, 2021; 13 (11)

Simple Summary Metastasis in general represents the progression phenotype whereby cancer cells break from a malignant primary location and travel to a......

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