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Single-cell analyses reveal suppressive tumor microenvironment of human colorectal cancer

期刊: CLINICAL AND TRANSLATIONAL MEDICINE, 2021; 11 (6)

Profiling heterologous cell types within tumors is essential to decipher tumor microenvironment that shapes tumor progress and determines the outcome ......

Functional inhibition of lactate dehydrogenase suppresses pancreatic adenocarcinoma progression

期刊: CLINICAL AND TRANSLATIONAL MEDICINE, 2021; 11 (6)

Background Pancreatic adenocarcinoma (PAAD) a highly lethal malignancy. The current use of clinical parameters may not accurately predict the clinical......

Activated factor X targeted stored in platelets as an effective gene therapy strategy for both hemophilia A and B

期刊: CLINICAL AND TRANSLATIONAL MEDICINE, 2021; 11 (3)

Background Treatment of hemophiliacs with inhibitors remains challenging, and new treatments are in urgent need. Coagulation factor X plays a critical......

A novel RANKL-targeted flavonoid glycoside prevents osteoporosis through inhibiting NFATc1 and reactive oxygen species

期刊: CLINICAL AND TRANSLATIONAL MEDICINE, 2021; 11 (5)

Background and purpose Osteoporosis is characterized by excessive bone resorption due to enhanced osteoclast activation. Stimulation of nuclear factor......

Deregulation of CLTC interacts with TFG, facilitating osteosarcoma via the TGF-beta and AKT/mTOR signaling pathways

期刊: CLINICAL AND TRANSLATIONAL MEDICINE, 2021; 11 (6)

Although the treatment of osteosarcoma has improved, the overall survival rate of this common type of osseous malignancies has not changed for four de......

Emerging roles of exosomal miRNAs in diabetes mellitus

期刊: CLINICAL AND TRANSLATIONAL MEDICINE, 2021; 11 (6)

Exosomes are small extracellular vesicles 40-160 nm in diameter that are secreted by almost all cell types. Exosomes can carry diverse cargo including......

Medial septum tau accumulation induces spatial memory deficit via disrupting medial septum-hippocampus cholinergic pathway

期刊: CLINICAL AND TRANSLATIONAL MEDICINE, 2021; 11 (6)

Tau accumulation and cholinergic impairment are characteristic pathologies in Alzheimer's disease (AD). However, the causal role of tau accumulation i......

A comprehensive and universal approach for embryo testing in patients with different genetic disorders

期刊: CLINICAL AND TRANSLATIONAL MEDICINE, 2021; 11 (7)

Background In vitro fertilization (IVF) with preimplantation genetic testing (PGT) has markedly improved clinical pregnancy outcomes for carriers of g......

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