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The adenosine analog prodrug ATV006 is orally bioavailable and has preclinical efficacy against parental SARS-CoV-2 and variants

期刊: SCIENCE TRANSLATIONAL MEDICINE, 2022; 14 (661)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus driving the ongoing coronavirus disease 2019 (COVID-19) pandemic, continues to......

JIF:10.129

Miswiring of Merkel cell and pruriceptive C fiber drives the itch-scratch cycle

期刊: SCIENCE TRANSLATIONAL MEDICINE, 2022; 14 (653)

Itch sensation provokes the scratch reflex to protect us from harmful stimuli in the skin. Although scratching transiently relieves acute itch through......

JIF:10.129

Rescue of autosomal dominant hearing loss by in vivo delivery of mini dCas13X-derived RNA base editor

期刊: SCIENCE TRANSLATIONAL MEDICINE, 2022; 14 (654)

Programmable RNA editing tools enable the reversible correction of mutant transcripts, reducing the potential risk associated with permanent genetic c......

JIF:10.129

Intracavity generation of glioma stem cell-specific CAR macrophages primes locoregional immunity for postoperative glioblastoma therapy

期刊: SCIENCE TRANSLATIONAL MEDICINE, 2022; 14 (656)

Glioblastoma multiforme (GBM) remains incurable despite aggressive implementation of multimodal treatments after surgical debulking. Almost all patien......

JIF:10.129

The pancreatic clock is a key determinant of pancreatic fibrosis progression and exocrine dysfunction

期刊: SCIENCE TRANSLATIONAL MEDICINE, 2022; 14 (664)

Chronic pancreatitis (CP) is characterized by progressive fibrosis and exocrine dysregulation, which have long been considered irreversible. As a peri......

JIF:10.129

Loss of miR-31-5p drives hematopoietic stem cell malignant transformation and restoration eliminates leukemia stem cells in mice

期刊: SCIENCE TRANSLATIONAL MEDICINE, 2022; 14 (629)

Leukemia stem cells (LSCs) propagate leukemia and are responsible for the high frequency of relapse of treated patients. The ability to target LSCs re......

JIF:10.129

CECR2 drives breast cancer metastasis by promoting NF-kappa B signaling and macrophage-mediated immune suppression

期刊: SCIENCE TRANSLATIONAL MEDICINE, 2022; 14 (630)

Metastasis is the major cause of cancer-related deaths due to the lack of effective therapies. Emerging evidence suggests that certain epigenetic and ......

JIF:10.129

TRIB3 reduces CD8(+) T cell infiltration and induces immune evasion by repressing the STAT1-CXCL10 axis in colorectal cancer

期刊: SCIENCE TRANSLATIONAL MEDICINE, 2022; 14 (626)

High CD8(+) T cell infiltration in colorectal cancer (CRC) should suggest a favorable prognosis and a satisfactory response to immunotherapy; however,......

JIF:10.129

Exocrine pancreas regeneration modifies original pancreas to alleviate diabetes in mouse models

期刊: SCIENCE TRANSLATIONAL MEDICINE, 2022; 14 (656)

Diabetes is a major public health issue because of its widely epidemic nature and lack of cure. Here, we show that pancreas-derived mesenchymal stem c......

JIF:10.129

Risk assessment with gut microbiome and metabolite markers in NAFLD development

期刊: SCIENCE TRANSLATIONAL MEDICINE, 2022; 14 (648)

A growing body of evidence suggests interplay between the gut microbiota and the pathogenesis of nonalcoholic fatty liver disease (NAFLD). However, th......

JIF:10.129

GPR177 in A-fiber sensory neurons drives diabetic neuropathic pain via WNT-mediated TRPV1 activation

期刊: SCIENCE TRANSLATIONAL MEDICINE, 2022; 14 (639)

Diabetic neuropathic pain (DNP) is a common and devastating complication in patients with diabetes. The mechanisms mediating DNP are not completely el......

JIF:10.129

Gene therapy targeting protein trafficking regulator MOG1 in mouse models of Brugada syndrome, arrhythmias, and mild cardiomyopathy

期刊: SCIENCE TRANSLATIONAL MEDICINE, 2022; 14 (648)

Brugada syndrome (BrS) is a fatal arrhythmia that causes an estimated 4% of all sudden death in high-incidence areas. SCN5A encodes cardiac sodium cha......

JIF:10.129

Hormonal therapies up-regulate MANF and overcome female susceptibility to immune checkpoint inhibitor myocarditis

期刊: SCIENCE TRANSLATIONAL MEDICINE, 2022; 14 (669)

Immune checkpoint inhibitors (ICIs) have been increasingly used in combination for cancer treatment but are associated with myocarditis. Here, we repo......

JIF:10.129

Dietary ketone body-escalated histone acetylation in megakaryocytes alleviates chemotherapy-induced thrombocytopenia

期刊: SCIENCE TRANSLATIONAL MEDICINE, 2022; 14 (673)

Chemotherapy-induced thrombocytopenia (CIT) is a severe complication in patients with cancer that can lead to impaired therapeutic outcome and surviva......

JIF:10.129

Aconitate decarboxylase 1 is a mediator of polymicrobial sepsis

期刊: SCIENCE TRANSLATIONAL MEDICINE, 2022; 14 (659)

Sepsis is a challenging clinical syndrome caused by a dysregulated host response to infection. Here, we identified an unexpected proseptic activity of......

JIF:10.129

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