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DNMT3a promotes osteoblast differentiation and alleviates osteoporosis via the PPAR gamma/SCD1/GLUT1 axis

期刊: EPIGENOMICS, 2022; 14 (12)

Background: This study was designed to elucidate the role of DNMT3a and PPAR gamma functions in postmenopausal osteoporosis. Materials & methods: ......

JIF:4.064

Circular RNA circTTBK2 facilitates non-small-cell lung cancer malignancy through the miR-873-5p/TEAD1/DERL1 axis

期刊: EPIGENOMICS, 2022; 14 (16)

Aim: The underlying mechanisms by which circular RNAs (circRNAs) regulate non-small-cell lung cancer (NSCLC) progression remain elusive. This study in......

JIF:4.064

Comprehensive analysis of epigenetic modifications and immune-cell infiltration in tissues from patients with systemic lupus erythematosus

期刊: EPIGENOMICS, 2022; 14 (2)

Aim: To explore potential abnormal epigenetic modifications and immune-cell infiltration in tissues from systemic lupus erythematosus (SLE) patients. ......

JIF:4.064

New developments in non-exosomal and exosomal ncRNAs in coronary artery disease

期刊: EPIGENOMICS, 2022; 14 (21)

Aim & methods: Non-exosomal and exosomal ncRNAs have been reported to be involved in the regulation of coronary artery disease (CAD). Therefore, t......

JIF:4.064

Ubiquitination and SUMOylation: protein homeostasis control over cancer

期刊: EPIGENOMICS, 2022; 14 (1)

Ubiquitination and SUMOylation are two essential components of the ubiquitination proteasome system playing fundamental roles in protein homeostasis m......

JIF:4.064

Evaluating the challenges and reproducibility of studies investigating DNA methylation signatures of psychological stress

期刊: EPIGENOMICS, 2022; 14 (7)

Psychological stress can increase the risk of a wide range of negative health outcomes. Studies have been completed to determine if DNA methylation ch......

JIF:4.064

A novel subtype to predict prognosis and treatment response with DNA driver methylation-transcription in ovarian cancer

期刊: EPIGENOMICS, 2022; 14 (18)

Tweetable abstract A novel multiomics subtype based on DNA driver methylation provides insights into ovarian cancer prognostic prediction and precisio......

JIF:4.064

DNA methylation status of DNAJA4 is essential for human erythropoiesis

期刊: EPIGENOMICS, 2022; 14 (20)

Aims: To investigate DNA methylation patterns in early and terminal stages of erythropoiesis, and to explore the function of differentially methylated......

JIF:4.064

hsa_circ_0092339 acts as a molecular sponge in castration-resistant prostate cancer via the hsa-mir-940/C-MYC axis

期刊: EPIGENOMICS, 2022; 14 (13)

Plain language summary Our research breaks the mold by investigating a novel function of RNA and a novel regulatory mechanism. Our research provides a......

JIF:4.064

Promotional effects of HIF1 alpha and KDM3A interaction on vascular smooth muscle cells in thoracic aortic dissection

期刊: EPIGENOMICS, 2022; 14 (5)

Aim: The current study was performed to define the role of KDM3A in thoracic aortic dissection (TAD). Methods: The binding of HIF1 alpha and KDM3A in ......

JIF:4.064

Analysis on methylation and expression of PSMB8 and its correlation with immunity and immunotherapy in lung adenocarcinoma

期刊: EPIGENOMICS, 2022; 14 (22)

Aim: To find biomarkers for immunity and immunotherapy in lung adenocarcinoma (LUAD) through multiomics analysis. Materials & methods: The multiom......

JIF:4.064

DNA methylation mediates the genetic variants on ticagrelor major metabolite elimination and platelet function recovery after ticagrelor discontinuation

期刊: EPIGENOMICS, 2022; 14 (10)

Aim: To investigate the influence of DNA methylation on ticagrelor major metabolite M8 elimination and platelet function recovery after ticagrelor dis......

JIF:4.064

Circular RNA expression profiles of ovarian granulosa cells in advanced-age women explain new mechanisms of ovarian aging

期刊: EPIGENOMICS, 2022; 14 (17)

Aim: We aimed to determine the role of granulosa cells (GCs) circular RNA (circRNA) in ovarian aging. Methods: Nine women were recruited, including th......

JIF:4.064

BRCA2 promoter hypermethylation as a biomarker for the leukemic transformation of myeloproliferative neoplasms

期刊: EPIGENOMICS, 2022; 14 (7)

Aim: To characterize the actionable biomarker for leukemic transformation (LT) of myeloproliferative neoplasms (MPNs) at the DNA damage repair promote......

JIF:4.064

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