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USP22 promotes hypoxia-induced hepatocellular carcinoma stemness by a HIF1 alpha/USP22 positive feedback loop upon TP53 inactivation

期刊: GUT, 2020; 69 (7)

Objective We aimed to elucidate the mutual regulation mechanism of ubiquitin-specific protease 22 (USP22) and hypoxia inducible factor-1 alpha (HIF1 a......

miR-541 potentiates the response of human hepatocellular carcinoma to sorafenib treatment by inhibiting autophagy

期刊: GUT, 2020; 69 (7)

Objective Autophagy participates in the progression of hepatocellular carcinoma (HCC) and the resistance of HCC cells to sorafenib. We investigated th......

Genomic and transcriptomic profiling of carcinogenesis in patients with familial adenomatous polyposis

期刊: GUT, 2020; 69 (7)

Objective Familial adenomatous polyposis (FAP) is characterised by the development of hundreds to thousands of adenomas at different evolutionary stag......

A novel faecal Lachnoclostridium marker for the non-invasive diagnosis of colorectal adenoma and cancer

期刊: GUT, 2020; 69 (7)

Objective There is a need for early detection of colorectal cancer (CRC) at precancerous-stage adenoma. Here, we identified novel faecal bacterial mar......

Myristoleic acid produced by enterococci reduces obesity through brown adipose tissue activation

期刊: GUT, 2020; 69 (7)

Objective Dietary fibre has beneficial effects on energy metabolism, and the majority of studies have focused on short-chain fatty acids produced by g......

METTL3-mediated m(6)A modification of HDGF mRNA promotes gastric cancer progression and has prognostic significance

期刊: GUT, 2020; 69 (7)

Objective N-6-methyladenosine (m(6)A) RNA methylation and its associated methyltransferase METTL3 are involved in tumour initiation and progression vi......

Systematic meta-analyses, field synopsis and global assessment of the evidence of genetic association studies in colorectal cancer

期刊: GUT, 2020; 69 (8)

Objective To provide an understanding of the role of common genetic variations in colorectal cancer (CRC) risk, we report an updated field synopsis an......

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