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Second generation androgen receptor antagonists and challenges in prostate cancer treatment

期刊: CELL DEATH & DISEASE, 2022; 13 (7)

Prostate cancer is a hormone-dependent malignancy, whose onset and progression are closely related to the activity of the androgen receptor (AR) signa......

JIF:6.28

Eukaryotic initiation factor 5A2 mediates hypoxia-induced autophagy and cisplatin resistance

期刊: CELL DEATH & DISEASE, 2022; 13 (8)

Hypoxia-induced cisplatin resistance is a major challenge during non-small cell lung cancer (NSCLC) treatment. Based on previous studies, we further e......

JIF:6.28

Regulatory T cells in skeletal muscle repair and regeneration: recent insights

期刊: CELL DEATH & DISEASE, 2022; 13 (8)

Skeletal muscle repair and regeneration after injury is a multi-stage process, involving a dynamic inflammatory microenvironment consisting of a compl......

JIF:6.28

Nuclear import of PTPN18 inhibits breast cancer metastasis mediated by MVP and importin beta 2

期刊: CELL DEATH & DISEASE, 2022; 13 (8)

Distant metastasis is the primary cause of breast cancer-associated death. The existing information, such as the precise molecular mechanisms and effe......

JIF:6.28

Astrocytic SARM1 promotes neuroinflammation and axonal demyelination in experimental autoimmune encephalomyelitis through inhibiting GDNF signaling

期刊: CELL DEATH & DISEASE, 2022; 13 (9)

Astrocytes are important components of the innate immune response in the central nervous system (CNS), involving in the inflammatory and neurotoxic re......

JIF:6.28

CircSEMA4B inhibits the progression of breast cancer by encoding a novel protein SEMA4B-211aa and regulating AKT phosphorylation

期刊: CELL DEATH & DISEASE, 2022; 13 (9)

PI3K/AKT signaling pathway plays an important role in regulating the tumorigenesis, recurrence, and metastasis of breast cancer (BC). In this study, w......

JIF:6.28

A dual Keap1 and p47(phox) inhibitor Ginsenoside Rb1 ameliorates high glucose/ox-LDL-induced endothelial cell injury and atherosclerosis

期刊: CELL DEATH & DISEASE, 2022; 13 (9)

Oxidative stress is a vital contributor to the development and progression of diabetes-accelerated atherosclerosis. Nuclear factor erythroid 2-related......

JIF:6.28

Androgen deprivation restores ARHGEF2 to promote neuroendocrine differentiation of prostate cancer

期刊: CELL DEATH & DISEASE, 2022; 13 (11)

Androgen receptor (AR) plays an important role in the progression of prostate cancer and has been targeted by castration or AR-antagonists. The emerge......

JIF:6.28

Hepatocyte-specific TMEM16A deficiency alleviates hepatic ischemia/reperfusion injury via suppressing GPX4-mediated ferroptosis

期刊: CELL DEATH & DISEASE, 2022; 13 (12)

Ischemia/reperfusion (I/R)-induced liver injury with severe cell death is a major complication of liver transplantation. Transmembrane member 16A (TME......

JIF:6.28

Epimedium protects against dyszoospermia in mice with Pex3 knockout by exerting antioxidant effects and regulating the expression level of P16

期刊: CELL DEATH & DISEASE, 2022; 13 (1)

Oxidative stress (OS) is one of the primary factors leading to male infertility. Oral administration of antioxidants has thus far been found to signif......

JIF:6.28

REV1 promotes lung tumorigenesis by activating the Rad18/SERTAD2 axis

期刊: CELL DEATH & DISEASE, 2022; 13 (2)

REV1 is the central member of the family of TLS polymerases, which participate in various DNA damage repair and tolerance pathways and play a signific......

JIF:6.28

DNAJB8 in small extracellular vesicles promotes Oxaliplatin resistance through TP53/MDR1 pathway in colon cancer

期刊: CELL DEATH & DISEASE, 2022; 13 (2)

Chemotherapy is one of the most frequently used therapies for the treatment of colon cancer (COAD). However, Oxaliplatin (L-OHP) resistance is a major......

JIF:6.28

Encoding gene RAB3B exists in linear chromosomal and circular extrachromosomal DNA and contributes to cisplatin resistance of hypopharyngeal squamous cell carcinoma via inducing autophagy

期刊: CELL DEATH & DISEASE, 2022; 13 (2)

Cisplatin (DDP) resistance is an important factor that decreases the effect of chemotherapy, thus leading to local recurrence and lymph node metastasi......

JIF:6.28

PCLAF promotes neuroblastoma G1/S cell cycle progression via the E2F1/PTTG1 axis

期刊: CELL DEATH & DISEASE, 2022; 13 (2)

PCLAF (PCNA clamp-associated factor), also known as PAF15/ KIAA0101, is overexpressed in most human cancers and is a predominant regulator of tumor pr......

JIF:6.28

Asparaginyl endopeptidase protects against podocyte injury in diabetic nephropathy through cleaving cofilin-1

期刊: CELL DEATH & DISEASE, 2022; 13 (2)

Podocyte injury and loss are critical events in diabetic nephropathy (DN); however, the underlying molecular mechanisms remain unclear. Here, we demon......

JIF:6.28

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