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rt269L-Type hepatitis B virus (HBV) in genotype C infection leads to improved mitochondrial dynamics via the PERK-eIF2α-ATF4 axis in an HBx protein-dependent manner

期刊: CELLULAR & MOLECULAR BIOLOGY LETTERS, 2023; 28 (1)

Background: In our previous report, the rt269I type versus the rt269L type in genotype C2 infection led to poor clinical outcomes and enhanced mitocho......

Oxidative stress as a key modulator of cell fate decision in osteoarthritis and osteoporosis: a narrative review

期刊: CELLULAR & MOLECULAR BIOLOGY LETTERS, 2023; 28 (1)

During aging and after traumatic injuries, cartilage and bone cells are exposed to various pathophysiologic mediators, including reactive oxygen speci......

Patterns of human and porcine gammaherpesvirus-encoded BILF1 receptor endocytosis

期刊: CELLULAR & MOLECULAR BIOLOGY LETTERS, 2023; 28 (1)

Background:The viral G-protein-coupled receptor (vGPCR) BILF1 encoded by the Epstein-Barr virus (EBV) is an oncogene and immunoevasin and can downregu......

Oscillatory shear stress modulates Notch-mediated endothelial mesenchymal plasticity in cerebral arteriovenous malformations

期刊: CELLULAR & MOLECULAR BIOLOGY LETTERS, 2023; 28 (1)

Background Cerebral arteriovenous malformations (cAVM) are a significant cause of intracranial hemorrhagic stroke and brain damage. The arteriovenous ......

Talin2 and KANK2 functionally interact to regulate microtubule dynamics, paclitaxel sensitivity and cell migration in the MDA-MB-435S melanoma cell line

期刊: CELLULAR & MOLECULAR BIOLOGY LETTERS, 2023; 28 (1)

Background: Focal adhesions (FAs) are integrin-containing, multi-protein structures that link intracellular actin to the extracellular matrix and trig......

Exogenous and endogenous dsRNAs perceived by plant Dicer-like 4 protein in the RNAi-depleted cellular context

期刊: CELLULAR & MOLECULAR BIOLOGY LETTERS, 2023; 28 (1)

Background: In plants, RNase III Dicer-like proteins (DCLs) act as sensors of dsRNAs and process them into short 21- to 24-nucleotide (nt) (s)RNAs. Pl......

EFR3A: a new raft domain organizing protein?

期刊: CELLULAR & MOLECULAR BIOLOGY LETTERS, 2023; 28 (1)

BackgroundMembrane rafts play a crucial role in the regulation of many important biological processes. Our previous data suggest that specific interac......

Genetically encoded phosphatidylserine biosensor for in vitro, ex vivo and in vivo labelling

期刊: CELLULAR & MOLECULAR BIOLOGY LETTERS, 2023; 28 (1)

BackgroundThe dynamics of phosphatidylserine in the plasma membrane is a tightly regulated feature of eukaryotic cells. Phosphatidylserine (PS) is fou......

Desmocollin-1 is associated with pro-metastatic phenotype of luminal A breast cancer cells and is modulated by parthenolide

期刊: CELLULAR & MOLECULAR BIOLOGY LETTERS, 2023; 28 (1)

Background: Desmocollin-1 (DSC1) is a desmosomal transmembrane glycoprotein that maintains cell-to-cell adhesion. DSC1 was previously associated with ......

Potential use of iPSCs for disease modeling, drug screening, and cell-based therapy for Alzheimer's disease

期刊: CELLULAR & MOLECULAR BIOLOGY LETTERS, 2023; 28 (1)

Alzheimer's disease (AD) is a chronic illness marked by increasing cognitive decline and nervous system deterioration. At this time, there is no known......

Prenatal lipopolysaccharide exposure induces anxiety-like behaviour in male mouse offspring and aberrant glial differentiation of embryonic neural stem cells

期刊: CELLULAR & MOLECULAR BIOLOGY LETTERS, 2023; 28 (1)

BackgroundPrenatal infection has been implicated in the development of neuropsychiatric disorders in children. We hypothesised that exposure to lipopo......

Comparison between 5 extractions methods in either plasma or serum to determine the optimal extraction and matrix combination for human metabolomics

期刊: CELLULAR & MOLECULAR BIOLOGY LETTERS, 2023; 28 (1)

Background: Although metabolomics continues to expand in many domains of research, methodological issues such as sample type, extraction and analytica......

Outside the limit: questioning the distance restrictions for cooperative miRNA binding sites

期刊: CELLULAR & MOLECULAR BIOLOGY LETTERS, 2023; 28 (1)

Among the concepts in biology that are widely taken granted is a potentiated cooperative effect of multiple miRNAs on the same target. This strong hyp......

Synaptic retrograde regulation of the PKA-induced SNAP-25 and Synapsin-1 phosphorylation

期刊: CELLULAR & MOLECULAR BIOLOGY LETTERS, 2023; 28 (1)

BackgroundBidirectional communication between presynaptic and postsynaptic components contribute to the homeostasis of the synapse. In the neuromuscul......

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