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SIRT2-dependent IDH1 deacetylation inhibits colorectal cancer and liver metastases

期刊: EMBO REPORTS, 2020; 21 (4)

Protein lysine acetylation affects colorectal cancer (CRC) distant metastasis through multiple pathways. In a previous proteomics screen, we found tha......

LncRNA GUARDIN suppresses cellular senescence through a LRP130-PGC1 alpha-FOXO4-p21-dependent signaling axis

期刊: EMBO REPORTS, 2020; 21 (4)

The long noncoding RNA GUARDIN functions to protect genome stability. Inhibiting GUARDIN expression can alter cell fate decisions toward senescence or......

Human RAP1 specifically protects telomeres of senescent cells from DNA damage

期刊: EMBO REPORTS, 2020; 21 (4)

Repressor/activator protein 1 (RAP1) is a highly evolutionarily conserved protein found at telomeres. Although yeast Rap1 is a key telomere capping pr......

YTHDF1-mediated translation amplifies Wnt-driven intestinal stemness

期刊: EMBO REPORTS, 2020; 21 (4)

N6-methyladenosine (m(6)A) mRNA methylation has emerged as an important player in many biological processes by regulating gene expression. However, it......

Hippocampal CD39/ENTPD1 promotes mouse depression-like behavior through hydrolyzing extracellular ATP

期刊: EMBO REPORTS, 2020; 21 (4)

Emerging evidence implicates that low levels of ATP in the extracellular space may contribute to the pathophysiology of major depressive disorder (MDD......

Placensin is a glucogenic hormone secreted by human placenta

期刊: EMBO REPORTS, 2020; 21 (6)

FBN1 encodes asprosin, a glucogenic hormone, following furin cleavage of the C-terminus of profibrillin 1. Based on evolutionary conservation between ......

The p38-interacting protein p38IP suppresses TCR and LPS signaling by targeting TAK1

期刊: EMBO REPORTS, 2020; 21 (7)

Negative regulation of immunoreceptor signaling is required for preventing hyperimmune activation and maintaining immune homeostasis. The roles of p38......

Transcription factor CDF4 promotes leaf senescence and floral organ abscission by regulating abscisic acid and reactive oxygen species pathways in Arabidopsis

期刊: EMBO REPORTS, 2020; 21 (7)

Leaf senescence is a highly complex developmental process that is tightly controlled by multiple layers of regulation. Abscisic acid (ABA) and reactiv......

PINK1 phosphorylates Drp1(S616) to regulate mitophagy-independent mitochondrial dynamics

期刊: EMBO REPORTS, 2020; 21 (8)

Impairment of PINK1/parkin-mediated mitophagy is currently proposed to be the molecular basis of mitochondrial abnormality in Parkinson's disease (PD)......

KUP9 maintains root meristem activity by regulating K+ and auxin homeostasis in response to low K

期刊: EMBO REPORTS, 2020; 21 (6)

Potassium (K) is essential for plant growth and development. Here, we show that the KUP/HAK/KT K+ transporter KUP9 controls primary root growth in Ara......

Phosphorylation of myelin regulatory factor by PRKG2 mediates demyelination in Huntington's disease

期刊: EMBO REPORTS, 2020; 21 (6)

Demyelination is a common pathological feature of a large number of neurodegenerative diseases including multiple sclerosis and Huntington's disease (......

TCF20 dysfunction leads to cortical neurogenesis defects and autistic-like behaviors in mice

期刊: EMBO REPORTS, 2020; 21 (8)

Recently, de novo mutations of transcription factor 20 (TCF20) were found in patients with autism by large-scale exome sequencing. However, how TCF20 ......

PABPN1L mediates cytoplasmic mRNA decay as a placeholder during the maternal-to-zygotic transition

期刊: EMBO REPORTS, 2020; 21 (8)

Maternal mRNA degradation is a critical event of the maternal-to-zygotic transition (MZT) that determines the developmental potential of early embryos......

Intellectual disability-associated gene ftsj1 is responsible for 2 '-O-methylation of specific tRNAs

期刊: EMBO REPORTS, 2020; 21 (8)

tRNA modifications at the anti-codon loop are critical for accurate decoding. FTSJ1 was hypothesized to be a human tRNA 2 '-O-methyltransferase. tRNA(......

Disrupted hypothalamicCRHneuron responsiveness contributes to diet-induced obesity

期刊: EMBO REPORTS, 2020; 21 (7)

The current obesity epidemic mainly results from high-fat high-caloric diet (HFD) feeding and may also be contributed by chronic stress; however, the ......

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