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Spatial transcriptomic profiling to identify mesoderm progenitors with precision genomic screening and functional confirmation

期刊: CELL PROLIFERATION, 2022; 55 (10)

Objectives Mesoderm, derived from a new layer between epiblast and hypoblast during gastrulation, can differentiate into various tissues, including mu......

JIF:6.494

GDF11 inhibits adipogenesis and improves mature adipocytes metabolic function via WNT/beta-catenin and ALK5/SMAD2/3 pathways

期刊: CELL PROLIFERATION, 2022; 55 (10)

Objective: GDF11 is a member of the TGF-beta superfamily that was recently implicated as potential rejuvenating factor, which can ameliorate metabolic......

JIF:6.494

LncSIK1 enhanced the sensitivity of AML cells to retinoic acid by the E2F1/autophagy pathway

期刊: CELL PROLIFERATION, 2022; 55 (3)

Objectives This study aimed to investigate the biological impacts and possible mechanisms of a novel lncRNA, LncSIK1, in AML progression and retinoic ......

JIF:6.494

In situ analysis of acupuncture protecting dopaminergic neurons from lipid peroxidative damage in mice of Parkinson's disease

期刊: CELL PROLIFERATION, 2022; 55 (4)

Objectives Acupuncture stimulation has proven to protect dopaminergic neurons from oxidative damage in animal models of Parkinson's disease (PD), but ......

JIF:6.494

Phosphorylation of Yun is required for stem cell proliferation and tumorigenesis

期刊: CELL PROLIFERATION, 2022; 55 (5)

Stem cells maintain adult tissue homeostasis under physiological conditions. Uncontrolled stem cell proliferation will lead to tumorigenesis. How stem......

JIF:6.494

Alteration in Rab11-mediated endocytic trafficking of LDL receptor contributes to angiotensin II-induced cholesterol accumulation and injury in podocytes

期刊: CELL PROLIFERATION, 2022; 55 (6)

Objectives Exposure of podocytes to angiotensin II (Ang II) enhances the abundance of the cell surface glycoprotein, low-density lipoprotein receptor ......

JIF:6.494

An optimized method for obtaining clinical-grade specific cell subpopulations from human umbilical cord-derived mesenchymal stem cells

期刊: CELL PROLIFERATION, 2022; 55 (10)

Mesenchymal stem cells (MSCs) are heterogeneous populations with broad application prospects in cell therapy, and using specific subpopulations of MSC......

JIF:6.494

Mutant C/EBP alpha p30 alleviates immunosuppression of CD8(+) T cells by inhibiting autophagy-associated secretion of IL-1 beta in AML

期刊: CELL PROLIFERATION, 2022; 55 (12)

Objectives Mutant C/EBP alpha p30 (mp30), the product of C/EBP alpha double mutations (DM), lacks transactivation domain 1 and has C-terminal loss-of-......

JIF:6.494

The inhibition of enterocyte proliferation by lithocholic acid exacerbates necrotizing enterocolitis through downregulating the Wnt/beta-catenin signalling pathway

期刊: CELL PROLIFERATION, 2022; 55 (5)

Objectives Necrotizing enterocolitis (NEC) is a catastrophic gastrointestinal emergency in preterm infants, whose exact aetiology remains unknown. The......

JIF:6.494

Altered gut microbiota and metabolites profile are associated with reduced bone metabolism in ethanol-induced osteoporosis

期刊: CELL PROLIFERATION, 2022; 55 (7)

Objective Chronic heavy drinking causes ethanol-induced osteoporosis (EIO). The present study aimed to explore the role of GM in EIO. Material and Met......

JIF:6.494

Dynamic changes of exhaustion features in T cells during oral carcinogenesis

期刊: CELL PROLIFERATION, 2022; 55 (4)

Objectives This study aimed to clarify the dynamic changes of exhaustion features in T cells during oral carcinogenesis. Materials and Methods Mice we......

JIF:6.494

METTL3-m(6)A methylase regulates the osteogenic potential of bone marrow mesenchymal stem cells in osteoporotic rats via the Wnt signalling pathway

期刊: CELL PROLIFERATION, 2022; 55 (5)

Objectives Bone marrow mesenchymal stem cells (BMSCs) hold a high osteogenic differentiation potential, but the mechanisms that control the osteogenic......

JIF:6.494

Scalable manufacturing of clinical-grade differentiated cardiomyocytes derived from human-induced pluripotent stem cells for regenerative therapy

期刊: CELL PROLIFERATION, 2022; 55 (8)

Basic research on human pluripotent stem cell (hPSC)-derived cardiomyocytes (CMs) for cardiac regenerative therapy is one of the most active and compl......

JIF:6.494

CD33-targeting extracellular vesicles deliver antisense oligonucleotides against FLT3-ITD and miR-125b for specific treatment of acute myeloid leukaemia

期刊: CELL PROLIFERATION, 2022; 55 (9)

Introduction Acute Myeloid Leukaemia (AML) is the most common blood cancer in adults. Although 2 out of 3 AML patients go into total remission after c......

JIF:6.494

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