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Neural signatures of hyperdirect pathway activity in Parkinson's disease

期刊: NATURE COMMUNICATIONS, 2021; 12 (1)

In Parkinson's disease (PD), beta frequency oscillations are synchronised across the cortico-basal-ganglia circuit. The authors show in human particip......

Peroxisome inspired hybrid enzyme nanogels for chemodynamic and photodynamic therapy

期刊: NATURE COMMUNICATIONS, 2021; 12 (1)

Peroxisome, a special cytoplasmic organelle, possesses one or more kinds of oxidases for hydrogen peroxide (H2O2) production and catalase for H2O2 deg......

Magnetic skyrmion braids

期刊: NATURE COMMUNICATIONS, 2021; 12 (1)

Skyrmions are vortex-like spin textures that form strings in magnetic crystals. Due to the analogy to elastic strings, skyrmion strings are naturally ......

Observation of higher-order non-Hermitian skin effect

期刊: NATURE COMMUNICATIONS, 2021; 12 (1)

Beyond the scope of Hermitian physics, non-Hermiticity fundamentally changes the topological band theory, leading to interesting phenomena, e.g., non-......

Pan-cancer circulating tumor DNA detection in over 10,000 Chinese patients

期刊: NATURE COMMUNICATIONS, 2021; 12 (1)

Circulating tumor DNA (ctDNA) provides a noninvasive approach to elucidate a patient's genomic landscape and actionable information. Here, we design a......

Genome-wide analyses of behavioural traits are subject to bias by misreports and longitudinal changes

期刊: NATURE COMMUNICATIONS, 2021; 12 (1)

Genome-wide association studies (GWAS) have discovered numerous genetic variants associated with human behavioural traits. However, behavioural traits......

In-situ generation of large numbers of genetic combinations for metabolic reprogramming via CRISPR-guided base editing

期刊: NATURE COMMUNICATIONS, 2021; 12 (1)

Reprogramming complex cellular metabolism requires simultaneous regulation of multigene expression. Ex-situ cloning-based methods are commonly used, b......

Ultrastable liquid crystalline blue phase from molecular synergistic self-assembly

期刊: NATURE COMMUNICATIONS, 2021; 12 (1)

Fabricating functional materials via molecular self-assembly is a promising approach, and precisely controlling the molecular building blocks of nanos......

miR-135a-5p mediates memory and synaptic impairments via the Rock2/Adducin1 signaling pathway in a mouse model of Alzheimer's disease

期刊: NATURE COMMUNICATIONS, 2021; 12 (1)

Aberrant regulation of microRNAs (miRNAs) has been implicated in the pathogenesis of Alzheimer's disease (AD), but most abnormally expressed miRNAs fo......

Host-derived lipids orchestrate pulmonary gamma delta T cell response to provide early protection against influenza virus infection

期刊: NATURE COMMUNICATIONS, 2021; 12 (1)

Innate immunity is important for host defense by eliciting rapid anti-viral responses and bridging adaptive immunity. Here, we show that endogenous li......

Efficiency stagnation in global steel production urges joint supply- and demand-side mitigation efforts

期刊: NATURE COMMUNICATIONS, 2021; 12 (1)

Steel production is a difficult-to-mitigate sector that challenges climate mitigation commitments. Efforts for future decarbonization can benefit from......

Thiazoline-related innate fear stimuli orchestrate hypothermia and anti-hypoxia via sensory TRPA1 activation

期刊: NATURE COMMUNICATIONS, 2021; 12 (1)

Thiazoline-related innate fear-eliciting compounds (tFOs) orchestrate hypothermia, hypometabolism, and anti-hypoxia, which enable survival in lethal h......

Orthogonal photochemistry-assisted printing of 3D tough and stretchable conductive hydrogels

期刊: NATURE COMMUNICATIONS, 2021; 12 (1)

3D-printing tough conductive hydrogels (TCHs) with complex structures is still a challenging task in related fields due to their inherent contrasting ......

The E3 ligase MREL57 modulates microtubule stability and stomatal closure in response to ABA

期刊: NATURE COMMUNICATIONS, 2021; 12 (1)

Regulation of stomatal movement is critical for plant adaptation to environmental stresses. The microtubule cytoskeleton undergoes disassembly, which ......

Hypothalamic Rax(+) tanycytes contribute to tissue repair and tumorigenesis upon oncogene activation in mice

期刊: NATURE COMMUNICATIONS, 2021; 12 (1)

Hypothalamic tanycytes in median eminence (ME) are emerging as a crucial cell population that regulates endocrine output, energy balance and the diffu......

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