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Targeting Cell Metabolism as Cancer Therapy

期刊: ANTIOXIDANTS & REDOX SIGNALING, 2020; 32 (5)

-oxidation needs during tumor proliferation and metastasis. The common induction of metabolic pathways during cancer progression, regardless of cancer......

Biological Effects of Morpholin-4-Ium 4 Methoxyphenyl (Morpholino) Phosphinodithioate and Other Phosphorothioate-Based Hydrogen Sulfide Donors

期刊: ANTIOXIDANTS & REDOX SIGNALING, 2020; 32 (2)

Significance: Hydrogen sulfide (H2S) is regarded as the third gasotransmitter along with nitric oxide and carbon monoxide. Extensive studies have demo......

The Benefits of Macromolecular/Supramolecular Approaches in Hydrogen Sulfide Delivery: A Review of Polymeric and Self-Assembled Hydrogen Sulfide Donors

期刊: ANTIOXIDANTS & REDOX SIGNALING, 2020; 32 (2)

Significance: Cell homeostasis and redox balance are regulated in part by hydrogen sulfide (H2S), a gaseous signaling molecule known as a gasotransmit......

Nitric Oxide Resistance, Induced in the Myocardium by Diabetes, Is Circumvented by the Nitric Oxide Redox Sibling, Nitroxyl

期刊: ANTIOXIDANTS & REDOX SIGNALING, 2020; 32 (1)

Aim: Impairment of tissue responsiveness to exogenous and endogenous nitric oxide (NO center dot), known as NO center dot resistance, occurs in many c......

Ascorbic Acid 2-Glucoside Stably Promotes the Primitiveness of Embryonic and Mesenchymal Stem Cells Through Ten-Eleven Translocation- and cAMP-Responsive Element-Binding Protein-1-Dependent Mechanisms

期刊: ANTIOXIDANTS & REDOX SIGNALING, 2020; 32 (1)

Aims: The naive or primitive states of stem cells (SCs) residing in specific niches are unstable and difficult to preserve in vitro. Vitamin C (VitC),......

Activity-Induced SUMOylation of Neuronal Nitric Oxide Synthase Is Associated with Plasticity of Synaptic Transmission and Extracellular Signal-Regulated Kinase 1/2 Signaling

期刊: ANTIOXIDANTS & REDOX SIGNALING, 2020; 32 (1)

Aims: Neuronal nitric oxide synthase (nNOS) and nitric oxide (NO) signaling have been implicated in learning, memory, and underlying long-lasting syna......

Functional Characterization of Knock-In Mice Expressing a 12/15-Lipoxygenating Alox5 Mutant Instead of the 5-Lipoxygenating Wild-Type Enzyme

期刊: ANTIOXIDANTS & REDOX SIGNALING, 2020; 32 (1)

Aims: Most mammalian genomes involve several genes encoding for functionally distinct arachidonate lipoxygenase (ALOX isoforms). Proinflammatory leuko......

Carbon Monoxide Inhibits T Cell Proliferation by Suppressing Reactive Oxygen Species Signaling

期刊: ANTIOXIDANTS & REDOX SIGNALING, 2020; 32 (7)

Aims: Carbon monoxide (CO) confers antiproliferative effects on T cells; however, how these effects are produced remains unclear. Reactive oxygen spec......

Nuclear Factor Erythroid-Derived 2-Like 2-Induced Reductive Stress Favors Self-Renewal of Breast Cancer Stem-Like Cells via the FoxO3a-Bmi-1 Axis

期刊: ANTIOXIDANTS & REDOX SIGNALING, 2020; 32 (18)

Aims: A subpopulation of cancer cells, termed cancer stem cells (CSCs), has stemness properties, such as self-renewal and differentiation, which drive......

The Good and the Bad Side of Heme-Oxygenase-1 in the Gut

期刊: ANTIOXIDANTS & REDOX SIGNALING, 2020; 32 (14)

Significance: Mucosal immunity in the gut has the important task of protecting an organism against potential danger, but at the same time of staying s......

Malabaricone C Attenuates Nonsteroidal Anti-Inflammatory Drug-Induced Gastric Ulceration by Decreasing Oxidative/Nitrative Stress and Inflammation and Promoting Angiogenic Autohealing

期刊: ANTIOXIDANTS & REDOX SIGNALING, 2020; 32 (11)

Aims: Nonsteroidal anti-inflammatory drugs (NSAIDs), among the most commonly used drugs worldwide, are associated with gastrointestinal (GI) complicat......

SOD3 Is Secreted by Adipocytes and Mitigates High-Fat Diet-Induced Obesity, Inflammation, and Insulin Resistance

期刊: ANTIOXIDANTS & REDOX SIGNALING, 2020; 32 (3)

Aims: To study the expression and regulatory role of SOD3 in adipocytes and adipose tissue. Results: SOD3 expression was determined in various tissues......

Regulation of T Cell Function by Reactive Nitrogen and Oxygen Species in Collagen-Induced Arthritis

期刊: ANTIOXIDANTS & REDOX SIGNALING, 2020; 32 (3)

Aims: In this study, we investigate the role of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in autoimmune diseases. We focus on ......

Golgi Stress Response, Hydrogen Sulfide Metabolism, and Intracellular Calcium Homeostasis

期刊: ANTIOXIDANTS & REDOX SIGNALING, 2020; 32 (9)

Aims: The physiological and pathological importance of hydrogen sulfide (H2S) as a novel gasotransmitter has been widely recognized. Cystathionine gam......

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