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Safety and efficacy of atezolizumab plus bevacizumab in patients with unresectable hepatocellular carcinoma in early clinical practice: A multicenter analysis

期刊: HEPATOLOGY RESEARCH, 2022; 52 (3)

Purpose To assess the impact of clinical factors on the safety and efficacy of atezolizumab plus bevacizumab (ATZ + BV) treatment in patients with unr......

JIF:3.772

Hyperprogressive disease in patients with unresectable hepatocellular carcinoma receiving atezolizumab plus bevacizumab therapy

期刊: HEPATOLOGY RESEARCH, 2022; 52 (3)

Background Atezolizumab plus bevacizumab was approved for hepatocellular carcinoma (HCC) patients in 2020, but treatment outcomes of atezolizumab plus......

JIF:3.772

Association of early bevacizumab interruption with efficacy of atezolizumab plus bevacizumab for advanced hepatocellular carcinoma: A landmark analysis

期刊: HEPATOLOGY RESEARCH, 2022; 52 (5)

Aim The present study focused on the association of early bevacizumab (Bev) interruption with the clinical outcome of atezolizumab plus bevacizumab. M......

JIF:3.772

Sofosbuvir-velpatasvir in adults with hepatitis C virus infection and compensated cirrhosis in Japan

期刊: HEPATOLOGY RESEARCH, 2022; 52 (10)

Background & Purpose Protease-free regimens for chronic hepatitis C virus (HCV) infection are safe and effective for persons with either compensat......

JIF:3.772

Diagnosis of hepatic steatosis based on ultrasound attenuation imaging is not influenced by liver fibrosis

期刊: HEPATOLOGY RESEARCH, 2022; 52 (12)

Aim Recently, a new technique using attenuation imaging (ATI) was developed to diagnose hepatic steatosis. The aim of this study was to investigate wh......

JIF:3.772

MAFLD: Renovation of clinical practice and disease awareness of fatty liver

期刊: HEPATOLOGY RESEARCH, 2022; 52 (5)

Recently, international expert panels have proposed a new definition of fatty liver: metabolic dysfunction-associated fatty liver disease (MAFLD). MAF......

JIF:3.772

2-Step PLT16-AST44 method: Simplified liver fibrosis detection system in patients with non-alcoholic fatty liver disease

期刊: HEPATOLOGY RESEARCH, 2022; 52 (4)

Aim Accurate detection of the hepatic fibrosis stage is essential to estimate the outcome of patients with non-alcoholic fatty liver disease (NAFLD). ......

JIF:3.772

Chronic liver disease questionnaire to manage patients with chronic liver diseases

期刊: HEPATOLOGY RESEARCH, 2022; 52 (8)

Background and Aims Although patients with chronic liver disease (CLD) usually show few symptoms, they exhibit decreased health-related QOL (HRQOL) wi......

JIF:3.772

Carbon-ion radiotherapy versus radiofrequency ablation as initial treatment for early-stage hepatocellular carcinoma

期刊: HEPATOLOGY RESEARCH, 2022; 52 (12)

Aim: Carbon-ion radiotherapy (C-ion RT) has shown potential as a curative treatment for patients with hepatocellular carcinoma (HCC). However, no repo......

JIF:3.772

Ratio of von Willebrand factor antigen to ADAMTS13 activity is a useful biomarker for acute-on-chronic liver failure development and prognosis in patients with liver cirrhosis

期刊: HEPATOLOGY RESEARCH, 2022; 52 (4)

Aim Acute-on-chronic liver failure (ACLF) is associated with a high risk of short-term mortality after progression to multiple organ failure. A disint......

JIF:3.772

Serum matrix metalloproteinase-7 in biliary atresia: A Japanese multicenter study

期刊: HEPATOLOGY RESEARCH, 2022; 52 (5)

Background Biliary atresia (BA) is among the commonest indications for liver transplantation (LT) in children. We examined whether serum matrix metall......

JIF:3.772

Risk factors for relapse of autoimmune hepatitis in Japan: A nationwide survey

期刊: HEPATOLOGY RESEARCH, 2022; 52 (7)

Aim: Some autoimmune hepatitis (AIH) patients experience relapse during their clinical course, and some risk factors for relapse have been identified ......

JIF:3.772

High fatty liver index is an independent predictor of ischemic heart disease during a 10-year period in a Japanese population

期刊: HEPATOLOGY RESEARCH, 2022; 52 (8)

Aim Fatty liver index (FLI), which is calculated by using body mass index, waist circumference and levels of gamma-glutamyl transferase and triglyceri......

JIF:3.772

Robust antiviral responses in severe hepatitis flare persist after early retreatment cessation and lead toward hepatitis B surface antigen loss: A proof-of-concept study

期刊: HEPATOLOGY RESEARCH, 2022; 52 (10)

Aim: Hepatitis B flare has been interpreted as result of immune response against upsurging hepatitis B virus (HBV) and its antigen(s) that may lead to......

JIF:3.772

Low syntaxin 17 expression in donor liver is associated with poor graft prognosis in recipients of living donor liver transplantation

期刊: HEPATOLOGY RESEARCH, 2022; 52 (10)

Aim Liver transplantation (LT) is the only curative therapy for decompensated liver cirrhosis. For recipients of living donor LT (LDLT), restoration o......

JIF:3.772

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