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Involvement of Bmal1 and Clock in Bromobenzene Metabolite-Induced Diurnal Renal Toxicity

期刊: BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2023; 46 (6)

Circadian rhythms are endogenous oscillators that regulate 24 h behavioral and physiological processes. Our previous investigation demonstrated that b......

Decreased Analgesic Effect of Tramadol in Japanese Patients with CYP2D6 Intermediate Metabolizers after Orthopedic Surgery

期刊: BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2023; 46 (7)

Tramadol is metabolized by CYP2D6 to an active metabolite, which in turn acts as an analgesic. This study aimed to investigate the impact of CYP2D6 ge......

The Involvement of Progranulin for α-Synuclein Reduction through Autolysosome Formation

期刊: BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2023; 46 (8)

Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor symptoms and neuropathological features, such as loss of dopaminergic ......

Turkish Plants, Including Quercetin and Oenothein B, Inhibit the HIV-1 Release and Accelerate Cell Apoptosis

期刊: BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2023; 46 (11)

The introduction of combined anti-retroviral therapy (cART) in 1996, along with a continual breakthrough in anti-human immunodeficiency virus-1 (HIV-1......

RasGRP2 Attenuates Oxygen Deprivation-Induced Autophagy in Vascular Endothelial Cells

期刊: BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2023; 46 (11)

Vascular endothelial cells sustain vascular health through barrier and endocrine functions. Insufficient oxygen supply induces endothelial dysfunction......

The Plasma Membrane Polarity Is Higher in the Neuronal Growth Cone than in the Cell Body of Hippocampal and Cerebellar Granule Neurons

期刊: BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2023; 46 (12)

The polarity of the biological membrane, or lipid order, regulates many cellular events. It is generally believed that the plasma membrane polarity is......

The Effect of Iontophoretic-Delivered Polyplex Vaccine on Melanoma Regression

期刊: BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2023; 46 (3)

Although the strategy in cancer vaccination is to provide a therapeutic effect against an established tumor, there is an urgent need to develop prophy......

The Antimicrobial Peptide Esculentin-1a(1-21)NH2 Stimulates Wound Healing by Promoting Angiogenesis through the PI3K/AKT Pathway

期刊: BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2023; 46 (3)

Delayed wound healing is a persistent medical problem mainly caused by decreased angiogenesis. Esculentin-1a(1-21)NH2 [Esc-1a(1-21)NH2], has broad-spe......

ELK3 Targeting AEG1 Promotes Migration and Invasion of Ovarian Cancer Cells under Hypoxia

期刊: BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2023; 46 (7)

Ovarian cancer (OC) is one of the most common tumors in female reproductive organs with a five-year survival rate of less than 45%. Metastasis is a cr......

Forsythiaside A Alleviates Lipopolysaccharide-Induced Acute Liver Injury through Inhibiting Endoplasmic Reticulum Stress and NLRP3 Inflammasome Activation

期刊: BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2023; 46 (7)

The liver is the primary site of inflammation caused by bacterial endotoxins in sepsis, and septic acute liver injury (SALI) is usually associated wit......

CDK9 Inhibitor Induces Apoptosis, Autophagy, and Suppression of Tumor Growth in Adult T-Cell Leukemia/Lymphoma

期刊: BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2023; 46 (9)

Adult T-cell leukemia/lymphoma (ATL) is a hematopoietic malignancy with a poor prognosis that develops in approximately 5% of human T-cell leukemia vi......

Dendrobium officinale Extract Fermented with Lactobacillus plantarum GT-17F Enhances the Protection of UV-Mediated Photoaging

期刊: BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2023; 46 (10)

Long-term and extensive exposure to UV irradiation can cause sunburn, photoaging, or skin cancer. Various studies have shown that Dendrobium officinal......

Nanoparticles Encapsulated γ-Oryzanol as a Natural Prodrug of Ferulic Acid for the Treatment of Oxidative Liver Damage

期刊: BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2023; 46 (10)

Antioxidants are promising therapeutics for treating oxidative stress-mediated liver diseases. Previously, we studied a potent natural antioxidant, fe......

CCL17 Blockade by CCL17mAb/GSK-J4 Ameliorates Hyperalgesia in a Rat Model of Postoperative Pain

期刊: BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2023; 46 (4)

C-C motif chemokine ligand 17 (CCL17), an important chemokine, plays a vital role in regulating im-mune balance in the central nervous system. In this......

Rapid Screening Detection of Genetically Modified Papaya by Loop-Mediated Isothermal Amplification

期刊: BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2023; 46 (5)

A loop-mediated isothermal amplification (LAMP)-mediated screening detection method for genetically modified (GM) papaya was developed targeting the 3......

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