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Gasdermin E mediates resistance of pancreatic adenocarcinoma to enzymatic digestion through a YBX1-mucin pathway

期刊: NATURE CELL BIOLOGY, 2022; 24 (3)

Pancreatic ductal adenocarcinoma (PDAC) originates from normal pancreatic ducts where digestive juice is regularly produced. It remains unclear how PD......

JIF:15.807

Itaconate inhibits TET DNA dioxygenases to dampen inflammatory responses

期刊: NATURE CELL BIOLOGY, 2022; 24 (3)

As one of the most induced genes in activated macrophages, immune-responsive gene 1 (IRG1) encodes a mitochondrial metabolic enzyme catalysing the pro......

JIF:15.807

Recycling of autophagosomal components from autolysosomes by the recycler complex

期刊: NATURE CELL BIOLOGY, 2022; 24 (4)

Autolysosomes contain components from autophagosomes and lysosomes. The contents inside the autolysosomal lumen are degraded during autophagy, while t......

JIF:15.807

A feedback loop engaging propionate catabolism intermediates controls mitochondrial morphology

期刊: NATURE CELL BIOLOGY, 2022; 24 (4)

d-2-Hydroxyglutarate (D-2HG) is an alpha-ketoglutarate-derived mitochondrial metabolite that causes d-2-hydroxyglutaric aciduria, a devastating develo......

JIF:15.807

Allele-specific H3K9me3 and DNA methylation co-marked CpG-rich regions serve as potential imprinting control regions in pre-implantation embryo

期刊: NATURE CELL BIOLOGY, 2022; 24 (5)

Parental DNA methylation and histone modifications undergo distinct global reprogramming in mammalian pre-implantation embryos, but the landscape of e......

JIF:15.807

Assembly of Tetraspanin-enriched macrodomains contains membrane damage to facilitate repair

期刊: NATURE CELL BIOLOGY, 2022; 24 (6)

Various mechanisms contribute to membrane repair(1-3) but the machinery that mediates the repair of large wounds on the plasma membrane is less clear.......

JIF:15.807

Ultrasensitive Ribo-seq reveals translational landscapes during mammalian oocyte-to-embryo transition and pre-implantation development

期刊: NATURE CELL BIOLOGY, 2022; 24 (6)

In mammals, translational control plays critical roles during oocyte-to-embryo transition (OET) when transcription ceases. However, the underlying reg......

JIF:15.807

KCNQ1OT1 promotes genome-wide transposon repression by guiding RNA-DNA triplexes and HP1 binding

期刊: NATURE CELL BIOLOGY, 2022; 24 (11)

Transposon (de)repression and heterochromatin reorganization are dynamically regulated during cell fate determination and are hallmarks of cellular se......

JIF:15.807

Elucidating minimal residual disease of paediatric B-cell acute lymphoblastic leukaemia by single-cell analysis

期刊: NATURE CELL BIOLOGY, 2022; 24 (2)

Zhang et al. perform single-cell RNA and B-cell receptor sequencing to characterize the transcriptomic profiles of B-cell acute lymphoblastic leukaemi......

JIF:15.807

ADAR1 downregulation by autophagy drives senescence independently of RNA editing by enhancing p16(INK4a) levels

期刊: NATURE CELL BIOLOGY, 2022; 24 (8)

Cellular senescence plays a causal role in ageing and, in mice, depletion of p16(INK4a)-expressing senescent cells delays ageing-associated disorders(......

JIF:15.807

The intrinsically disordered region from PP2C phosphatases functions as a conserved CO2 sensor

期刊: NATURE CELL BIOLOGY, 2022; 24 (7)

Carbon dioxide not only plays a central role in the carbon cycle, but also acts as a crucial signal in living cells. Adaptation to changing CO2 concen......

JIF:15.807

Fructose-1,6-bisphosphatase 1 functions as a protein phosphatase to dephosphorylate histone H3 and suppresses PPAR alpha-regulated gene transcription and tumour growth

期刊: NATURE CELL BIOLOGY, 2022; 24 (11)

Tumour cells exhibit greater metabolic plasticity than normal cells and possess selective advantages for survival and proliferation with unclearly def......

JIF:15.807

A non-canonical cGAS-STING-PERK pathway facilitates the translational program critical for senescence and organ fibrosis

期刊: NATURE CELL BIOLOGY, 2022; 24 (5)

Zhang et al. report that a non-canonical cGAS-STING pathway activates PERK-eIF2 alpha to elaborate cap-dependent mRNA translation and contributes to s......

JIF:15.807

Poly(ADP-ribosylation) of P-TEFb by PARP1 disrupts phase separation to inhibit global transcription after DNA damage

期刊: NATURE CELL BIOLOGY, 2022; 24 (4)

DNA damage shuts down genome-wide transcription to prevent transcriptional mutagenesis and to initiate repair signalling, but the mechanism to stall e......

JIF:15.807

BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2

期刊: NATURE CELL BIOLOGY, 2022; 24 (1)

SARS-CoV-2 infection of human cells is initiated by the binding of the viral Spike protein to its cell-surface receptor ACE2. We conducted a targeted ......

JIF:15.807

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