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Sex-dependent deterioration of cardiac function and molecular alterations in age- and disease-associated RAGE overexpression

期刊: MECHANISMS OF AGEING AND DEVELOPMENT, 2022; 203 ()

Elevated expression of the receptor for advanced-glycation endproducts (RAGE) in cardiac tissue is well-known in the elderly, in diabetes mellitus, an......

JIF:5.013

Circulating biomarkers of inflammaging as potential predictors of COVID-19 severe outcomes

期刊: MECHANISMS OF AGEING AND DEVELOPMENT, 2022; 204 ()

The COVID-19 pandemic caused by SARS-CoV-2 infection has been of unprecedented clinical and socio-economic worldwide relevance. The case fatality rate......

JIF:5.013

Social environment improves the cytokine profile and lymphoproliferative response in chronologically old and prematurely aging mice

期刊: MECHANISMS OF AGEING AND DEVELOPMENT, 2022; 206 ()

Among the age-associated changes in the immune system, the most evident is the decrease in proliferative responses of lymphocytes to mitogenic stimuli......

JIF:5.013

Leptin-depended NLRP3 inflammasome activation in osteoarthritic chondrocytes is mediated by ROS

期刊: MECHANISMS OF AGEING AND DEVELOPMENT, 2022; 208 ()

Leptin and ROS are implicated in the regulation of inflammatory pathways including NLRP3-inflammasome. We investigated the functional link between lep......

JIF:5.013

Association of a modified laboratory frailty index with adverse outcomes in geriatric rehabilitation inpatients: RESORT

期刊: MECHANISMS OF AGEING AND DEVELOPMENT, 2022; 203 ()

A higher number of laboratory measurements is associated with mortality in patients admitted to hospital, but is not part of the frailty index based o......

JIF:5.013

The relationship between telomere length and putative markers of vascular ageing: A systematic review and meta-analysis

期刊: MECHANISMS OF AGEING AND DEVELOPMENT, 2022; 201 ()

Accelerated biological aging contributes to the evolution of cardiovascular disease. However, its influence on subclinical organ damage remains unclea......

JIF:5.013

Impact of ageing, fall history and exercise on postural reflexes following unpredictable perturbations: A systematic review and meta-analyses

期刊: MECHANISMS OF AGEING AND DEVELOPMENT, 2022; 203 ()

Introduction: This review examined the impact of ageing, fall history and exercise on postural reflexes and adaptation to unpredictable perturbations.......

JIF:5.013

Metformin to treat Huntington disease: A pleiotropic drug against a multi-system disorder

期刊: MECHANISMS OF AGEING AND DEVELOPMENT, 2022; 204 ()

Huntington disease (HD) is a neurodegenerative disorder produced by an expansion of CAG repeats in the HTT gene. Patients of HD show involuntary movem......

JIF:5.013

Xenohormesis underlyes the anti-aging and healthy properties of olive polyphenols

期刊: MECHANISMS OF AGEING AND DEVELOPMENT, 2022; 202 ()

The paper provides a comprehensive and foundational mechanistic framework of hormesis that establishes its centrality in medicine and public health. T......

JIF:5.013

Circulating miR-320b and miR-483-5p levels are associated with COVID-19 in-hospital mortality

期刊: MECHANISMS OF AGEING AND DEVELOPMENT, 2022; 202 ()

The stratification of mortality risk in COVID-19 patients remains extremely challenging for physicians, especially in older patients. Innovative minim......

JIF:5.013

Genistein, a tool for geroscience

期刊: MECHANISMS OF AGEING AND DEVELOPMENT, 2022; 204 ()

Geroprotection is defined as protection from the adverse effects of aging. The need for geroprotection implies changes towards individually tailored i......

JIF:5.013

Counteracting aged DNA methylation states to combat ageing and age-related diseases

期刊: MECHANISMS OF AGEING AND DEVELOPMENT, 2022; 206 ()

DNA methylation (DNAm) overwrites information about multiple extrinsic factors on the genome. Age is one of these factors. Age causes characteristic D......

JIF:5.013

?-Amyloid promotes platelet activation and activated platelets act as bridge between risk factors and Alzheimer?s disease

期刊: MECHANISMS OF AGEING AND DEVELOPMENT, 2022; 207 ()

Alzheimer's disease (AD) is an evolving challenge that places an enormous burden on families and society. The presence of obvious brain beta-amyloid (......

JIF:5.013

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