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DP1 prostanoid receptor activation increases the severity of an acute lower respiratory viral infection in mice via TNF-alpha-induced immunopathology

期刊: MUCOSAL IMMUNOLOGY, 2021; 14 (4)

Respiratory syncytial virus (RSV) bronchiolitis is a leading cause of infant hospitalization and mortality. We previously identified that prostaglandi......

Cigarette smoke exposure attenuates the induction of antigen-specific IgA in the murine upper respiratory tract

期刊: MUCOSAL IMMUNOLOGY, 2021; 14 (5)

The upper respiratory tract is highly exposed to airborne pathogens and serves as an important inductive site for protective antibody responses, inclu......

Emc3 maintains intestinal homeostasis by preserving secretory lineages

期刊: MUCOSAL IMMUNOLOGY, 2021; 14 (4)

Intestinal exocrine secretory lineages, including goblet cells and Paneth cells, provide vital innate host defense to pathogens. However, how these ce......

Single-cell RNA sequencing analysis reveals alginate oligosaccharides preventing chemotherapy-induced mucositis

期刊: MUCOSAL IMMUNOLOGY, 2020; 13 (3)

Worldwide the incidence of cancer has been continuing increasing. Mucositis of the gastrointestinal tract is a common side effect in patients under ch......

IL-17 production by tissue-resident MAIT cells is locally induced in children with pneumonia

期刊: MUCOSAL IMMUNOLOGY, 2020; 13 (5)

Community-acquired pneumonia (CAP) contributes substantially to morbidity and mortality in children under the age of 5 years. In examining bronchoalve......

MicroRNA-219a-5p suppresses intestinal inflammation through inhibiting Th1/Th17-mediated immune responses in inflammatory bowel disease

期刊: MUCOSAL IMMUNOLOGY, 2020; 13 (2)

MicroRNA (miR)-219a-5p has been implicated in the development of numerous progression of carcinoma and autoimmune diseases. However, whether miR-219a-......

Treg expression of CIS suppresses allergic airway inflammation through antagonizing an autonomous TH2 program

期刊: MUCOSAL IMMUNOLOGY, 2020; 13 (2)

Maintenance of regulatory T (Treg) cells is crucial for the regulatory function of Treg cells in immune homeostasis and self-tolerance; however, the d......

Adrenomedullin insufficiency alters macrophage activities in fallopian tube: a pathophysiologic explanation of tubal ectopic pregnancy

期刊: MUCOSAL IMMUNOLOGY, 2020; 13 (5)

Ectopic pregnancy is the major cause of maternal morbidity and mortality in the first trimester of pregnancy. Tubal ectopic pregnancy (TEP) accounts f......

IL-33/ST2/IL-9/IL-9R signaling disrupts ocular surface barrier in allergic inflammation

期刊: MUCOSAL IMMUNOLOGY, 2020; 13 (6)

This study was to explore a novel IL-33/ST2/IL-9/IL-9R signaling pathway that disrupts ocular surface barrier and amplifies allergic inflammation. Two......

ADP/P2Y(1)aggravates inflammatory bowel disease through ERK5-mediated NLRP3 inflammasome activation

期刊: MUCOSAL IMMUNOLOGY, 2020; 13 (6)

Inflammasomes are essential for inflammation and pathogen elimination in response to microbial infection and endogenous danger signals. However, the m......

Animal and translational models of SARS-CoV-2 infection and COVID-19

期刊: MUCOSAL IMMUNOLOGY, 2020; 13 (6)

COVID-19 is causing a major once-in-a-century global pandemic. The scientific and clinical community is in a race to define and develop effective prev......

Slc6a13 deficiency promotes Th17 responses during intestinal bacterial infection

期刊: MUCOSAL IMMUNOLOGY, 2019; 12 (2)

The gamma-amino butyric acid (GABA)ergic system shapes the activation and function of immune cells. The present study was conducted to explore the reg......

JIF:7.35

Modulation of intestinal microbiota by glycyrrhizic acid prevents high-fat diet-enhanced pre-metastatic niche formation and metastasis

期刊: MUCOSAL IMMUNOLOGY, 2019; 12 (4)

High-fat diet (HFD) promotes lung pre-metastatic niche formation and metastasis. Thus, there is an urgent need to identify the underlying mechanisms a......

JIF:7.35

Deficiency in intestinal epithelial Reg4 ameliorates intestinal inflammation and alters the colonic bacterial composition

期刊: MUCOSAL IMMUNOLOGY, 2019; 12 (4)

yy The regenerating islet-derived family member 4 (Reg4) in the gastrointestinal tract is up-regulated during intestinal inflammation. However, the ph......

JIF:7.35

Age-associated antigen-presenting cell alterations promote dry-eye inducing Th1 cells

期刊: MUCOSAL IMMUNOLOGY, 2019; 12 (4)

Aging is a significant risk factor for dry eye. Here we used a murine aging model to investigate the effects of aging on antigen presenting cells (APC......

JIF:7.35

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