期刊： EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023; 258 ()
Although traditional EGFR-TKIs have advanced the treatment landscape of NSCLC with sensitive driver mutations (del19 or L858R), some NSCLC patients wi......
期刊： EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023; 258 ()
The major severe complications linked to Zika virus (ZIKV) cause the global public health problems, including microcephaly and other congenital abnorm......
期刊： EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023; 259 ()
The emergence of drug-resistant strains presents a grave challenge for traditional antibiotics, underscoring the exigency of exploring novel antibacte......
期刊： EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023; 259 ()
Cyclic dinucleotides (CDNs) trigger the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway, which plays a key role in cytosol......
期刊： EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023; 261 ()
The EGFRC797S mutation is a dominant mechanism of acquired resistance after the treatment of non-small cell lung cancer (NSCLC) with osimertinib in cl......
期刊： EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023; 262 ()
Targeted protein degradation (TPD) is one of the key strategies of current targeted cancer therapy, and it can eliminate some of the root causes of ca......
期刊： EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023; 247 ()
Cancer represents one of the world's biggest hazardous diseases. p53 is the uttermost researched tumour sup-pressor protein. It is commonly considered......
期刊： EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023; 246 ()
The available therapeutic treatment for leishmaniasis is inadequate and toxic due to side effects, expensive and emergence of drug resistance. Afforda......
期刊： EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023; 248 ()
The pursuit of activating the HDAC inhibitory template towards additional mechanisms spurred us to design dual modulators (Sig-1R agonist - HDAC inhib......
期刊： EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023; 248 ()
Noncovalent inhibitors of p97 have entered clinical studies. Compared with noncovalent inhibitors, covalent inhibitors have unique advantages in maint......
期刊： EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023; 250 ()
Inflammation is connected with a variety of diseases and there is still a need to develop more effective and safer anti-inflammatory drugs. Herein, we......
期刊： EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023; 250 ()
C-X-C motif chemokine receptor 2 (CXCR2) is G protein-coupled receptor (GPCR) and plays important roles in various inflammatory diseases and cancers, ......
期刊： EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023; 250 ()
Indoleamine 2,3-dioxygenase-1 (IDO1) has been considered as an attractive target for oncology immunotherapy due to its immunosuppressive effects on th......
期刊： EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023; 250 ()
The efficacy and resistance of cisplatin-based compounds are very intractable problems at present. This study reports a series of platinum(IV) compoun......
期刊： EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023; 252 ()
Butyrylcholinesterase (BChE) is one of the most frequently implicated enzymes in the advanced stage of Alz-heimer's disease (AD). As part of our endea......
