期刊: ARCHIV DER PHARMAZIE, 2023; 356 (2)
Searching for effective and selective anti-inflammatory agents, our study involved designing and synthesizing new pyrazole and pyrazolo[1,5-a]pyrimidi......
期刊: ARCHIV DER PHARMAZIE, 2023; 356 (4)
This study reports the design and synthesis of novel 1,2,4-triazolo/benzimidazolo-pyrimidine linked 1-benzyl-4-[(p-tolyloxy)methyl]-1,2,3-triazole der......
期刊: ARCHIV DER PHARMAZIE, 2023; 356 (6)
The endemicity of the pandemic coronavirus disease 2019 (COVID-19) infection proved to be transitional only. Spikes are forming again in 2023, and hig......
期刊: ARCHIV DER PHARMAZIE, 2023; 356 (3)
A series of pyridine compounds were prepared by using 3-(dimethylamino)-1-(pyridin-4-yl)prop-2-en-1-one (14) as a precursor. The reaction of 14 with d......
期刊: ARCHIV DER PHARMAZIE, 2023; 356 (3)
Centriole duplication occurs once per cell cycle and is regulated by Polo-like kinase 4 (PLK4). Overexpression of PLK4 in somatic cells can lead to th......
期刊: ARCHIV DER PHARMAZIE, 2023; 356 (5)
With the intent to discover new antituberculosis (TB) compounds, coumarin-thymidine analogs were synthesized using second-order nucleophilic substitut......
期刊: ARCHIV DER PHARMAZIE, 2023; 356 (12)
The PI3K/AKT/mTOR pathway is one of the most common dysregulated signaling cascade responses in human cancers, playing a crucial role in cell prolifer......
期刊: ARCHIV DER PHARMAZIE, 2023; 356 (8)
COVID-19 has caused many deaths since the first outbreak in 2019. The burden on healthcare systems around the world has been reduced by the success of......
期刊: ARCHIV DER PHARMAZIE, 2023; 356 (8)
The development of novel antimycobacterial agents is an urgent challenge to eradicate the increasing emergence and rapid spread of multidrug-resistant......
期刊: ARCHIV DER PHARMAZIE, 2023; 356 (9)
Anticancer drug conjugates are an emerging approach for future cancer treatment. Here, we report a series of hybrid ligands merging the neurohormone m......
期刊: ARCHIV DER PHARMAZIE, 2023; 356 (10)
Topoisomerases are ubiquitous enzymes in the human body, particularly involved in cancer development and progression. Topoisomerase I (topoI) performs......
期刊: ARCHIV DER PHARMAZIE, 2023; 356 (12)
A series of carvacrol-based thiosemicarbazide (3a-e) and 1,3,4-thiadiazole-2-amine (4a-e) were designed and synthesized for the first time. The struct......
期刊: ARCHIV DER PHARMAZIE, 2023; ()
Humanity is currently facing various diseases with significant mortality rates, particularly those associated with malignancies. Numerous enzymes and ......
期刊: ARCHIV DER PHARMAZIE, 2023; 356 (2)
Inhibition of human carbonic anhydrase (hCA) isoform IX with concurrent induction of apoptosis is a promising approach for targeting cancer in humans.......
期刊: ARCHIV DER PHARMAZIE, 2023; 356 (4)
Cryptococcus neoformans, an opportunistic fungal pathogen, causes cryptococcosis in immunocompromised persons. A series of modified L-histidines-conta......