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Dexamethasone leads to Zn2+ accumulation and increased unbound Zn2+ in C2C12 muscle and 3T3-L1 adipose cells

期刊: JOURNAL OF CELLULAR BIOCHEMISTRY, 2023; 124 (3)

Skeletal muscle atrophy is associated with increases in circulating glucocorticoid levels and insulin resistance. Zinc accumulates in atrophic muscle,......

Toward effective Atg8-based ATTECs: Approaches and perspectives

期刊: JOURNAL OF CELLULAR BIOCHEMISTRY, 2023; ()

Induction of Atg8-family protein (LC3/GABARAP proteins in human) interactions with target proteins of interest by proximity-inducing small molecules o......

Molecular dynamics simulations corroborate recombinant expression studies carried out on three αIIb β-propeller mutations reported in Indian Glanzmann thrombasthenia patients

期刊: JOURNAL OF CELLULAR BIOCHEMISTRY, 2023; 124 (7)

Mutations in the alpha IIb beta-propeller domain have long been known to disrupt heterodimerization and intracellular trafficking of alpha IIb beta 3 ......

EP1 receptor: Devil in emperors coat

期刊: JOURNAL OF CELLULAR BIOCHEMISTRY, 2023; 124 (8)

EP1 receptor belongs to prostanoid receptors and is activated by prostaglandin E2. The receptor performs contrasting functions in central nervous syst......

Combination of 3PO analog PFK15 and siPFKL efficiently suppresses the migration, colony formation ability, and PFK-1 activity of triple-negative breast cancers by reducing the glycolysis

期刊: JOURNAL OF CELLULAR BIOCHEMISTRY, 2023; 124 (9)

Among all the subtypes of breast cancer, triple-negative breast cancer (TNBC) has been associated with the worst prognosis. Recently, for many solid t......

Up-regulation of inflammatory reactions by MPT32, a secreted protein of Mycobacterium tuberculosis in RAW264.7 macrophages

期刊: JOURNAL OF CELLULAR BIOCHEMISTRY, 2023; 124 (9)

Tuberculosis (TB) is caused by Mycobacterium tuberculosis (Mtb) and is still one of the global health burdens. The occurrence of various cases and mul......

Mechanistic insights into the role of vitamin D and computational identification of potential lead compounds for Parkinson's disease

期刊: JOURNAL OF CELLULAR BIOCHEMISTRY, 2023; 124 (3)

Parkinson's disease (PD) is the second most common neurodegenerative disorder that affects dopaminergic neurons in the midbrain. A recent study sugges......

Inhibition of N-glycosylation by glucosamine hydrochloride inhibits TGF-β1-induced LOXL2 secretion

期刊: JOURNAL OF CELLULAR BIOCHEMISTRY, 2023; 124 (6)

Kidney fibrosis is closely associated with the progression of chronic kidney disease ( CKD). Furthermore, copper-containing secretory amine oxidases, ......

Mesenchymal stem cells and ovarian cancer: Is there promising news?

期刊: JOURNAL OF CELLULAR BIOCHEMISTRY, 2023; 124 (10)

Ovarian cancer (OC) is described as a heterogeneous complex condition with high mortality, weak prognosis, and late-stage presentation. OC has several......

Induced expression of miR-1250-5p exerts tumor suppressive role in triple-negative breast cancer cells

期刊: JOURNAL OF CELLULAR BIOCHEMISTRY, 2023; 124 (2)

Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, and it has a prevalence rate of 15%-20% among all breast cancer ......

The role of S477N mutation in the molecular behavior of SARS-CoV-2 spike protein: An in-silico perspective

期刊: JOURNAL OF CELLULAR BIOCHEMISTRY, 2023; 124 (2)

The attachment of SARA-CoV-2 happens between ACE2 and the receptor binding domain (RBD) on the spike protein. Mutations in this domain can affect the ......

How statin drugs affect exosomes?

期刊: JOURNAL OF CELLULAR BIOCHEMISTRY, 2023; 124 (2)

Statins reduce serum cholesterol and isoprenoids by the inhibition of cholesterol synthesis in the mevalonate pathway. Exosomes are extracellular vesi......

AIP4 regulates adipocyte differentiation by targeting C/EBPa for ubiquitin-mediated proteasomal degradation

期刊: JOURNAL OF CELLULAR BIOCHEMISTRY, 2023; 124 (7)

Adipogenesis, that is, the formation of terminally differentiated adipocytes is intricately regulated by transcription factors where CCAAT/enhancer bi......

Fibroblast-derived exosomal microRNA regulates NKX3-1 expression in androgen-sensitive, androgen receptor-dependent prostate cancer cells

期刊: JOURNAL OF CELLULAR BIOCHEMISTRY, 2023; 124 (8)

Androgen deprivation therapy (ADT) targeting androgen production and androgen receptor (AR) signaling is the primary antihormonal therapy in the treat......

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