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PD-1 Expression during Acute Infection Is Repressed through an LSD1-Blimp-1 Axis

期刊: JOURNAL OF IMMUNOLOGY, 2020; 204 (2)

During prolonged exposure to Ags, such as chronic viral infections, sustained TCR signaling can result in T cell exhaustion mediated in part by expres......

An Early Neutrophil Recruitment into the Infectious Site Is Critical for Bacterial Lipoprotein Tolerance-Afforded Protection against Microbial Sepsis

期刊: JOURNAL OF IMMUNOLOGY, 2020; 204 (2)

Bacterial lipoprotein (BLP)-induced tolerance represents an essential regulatory mechanism during bacterial infection and has been shown to protect ag......

Porcine Reproductive and Respiratory Syndrome Virus Enhances Self-Replication via AP-1-Dependent Induction of SOCS1

期刊: JOURNAL OF IMMUNOLOGY, 2020; 204 (2)

Porcine reproductive and respiratory syndrome virus (PRRSV) has caused tremendous economic losses in the swine industry since its emergence in the lat......

Neuronal Regulation of Cutaneous Immunity

期刊: JOURNAL OF IMMUNOLOGY, 2020; 204 (2)

The skin is innervated by numerous sensory afferent neurons that respond to a diverse array of stimuli ranging from gentle touch to noxious pain. Vari......

Brucella Infection Regulates Thioredoxin-Interacting Protein Expression to Facilitate Intracellular Survival by Reducing the Production of Nitric Oxide and Reactive Oxygen Species

期刊: JOURNAL OF IMMUNOLOGY, 2020; 204 (3)

Thioredoxin-interacting protein (TXNIP) is a multifunctional protein that functions in tumor suppression, oxidative stress, and inflammatory responses......

Naringenin Enhances the Antitumor Effect of Therapeutic Vaccines by Promoting Antigen Cross-Presentation

期刊: JOURNAL OF IMMUNOLOGY, 2020; 204 (3)

Dendritic cells (DCs) can internalize and cross-present exogenous Ags to CD8(+) T cells for pathogen or tumor cell elimination. Recently, growing evid......

Ca2+-Calcineurin Axis-Controlled NFAT Nuclear Translocation Is Crucial for Optimal T Cell Immunity in an Early Vertebrate

期刊: JOURNAL OF IMMUNOLOGY, 2020; 204 (3)

Calcium ion (Ca2+) is a widespread and primitive second messenger that regulates physiological cell functions in almost all life beings. Ca2+ influx-i......

IL-9 Controls Central Nervous System Autoimmunity by Suppressing GM-CSF Production

期刊: JOURNAL OF IMMUNOLOGY, 2020; 204 (3)

Multiple sclerosis and experimental autoimmune encephalomyelitis (EAE) are inflammatory diseases of the CNS in which Th17 cells play a major role in t......

Tolerogenic Dendritic Cells Generated by BAFF Silencing Ameliorate Collagen-Induced Arthritis by Modulating the Th17/Regulatory T Cell Balance

期刊: JOURNAL OF IMMUNOLOGY, 2020; 204 (3)

Tolerogenic dendritic cells (tolDCs) have received much attention because of their capacity to restore immune homeostasis. RNA interference techniques......

Maturation of an Antimicrobial Peptide Inhibits Aeromonas hydrophila Infection in Crayfish

期刊: JOURNAL OF IMMUNOLOGY, 2020; 204 (3)

Rapid synthesis and release of active antimicrobial peptides (AMPs) is an important strategy in innate immune. Processing of the precursor into the ac......

Neonatal Injury Increases Gut Permeability by Epigenetically Suppressing E-Cadherin in Adulthood

期刊: JOURNAL OF IMMUNOLOGY, 2020; 204 (4)

Altered intestinal epithelial integrity is an important susceptibility trait in inflammatory bowel disease (IBD), and early life stressors are reporte......

The Orphan Immune Receptor LILRB3 Modulates Fc Receptor-Mediated Functions of Neutrophils

期刊: JOURNAL OF IMMUNOLOGY, 2020; 204 (4)

Neutrophils are critical to the generation of effective immune responses and for killing invading microbes. Paired immune receptors provide important ......

Functional Variation of IL-1R-Associated Kinases in the Conserved MyD88-TRAF6 Pathway during Evolution

期刊: JOURNAL OF IMMUNOLOGY, 2020; 204 (4)

IL-1R-associated kinases (IRAK) are important regulators in the TLR/IL-1R pathways, but their function appears inconsistent between Drosophila, bony f......

IL-1 Transcriptional Responses to Lipopolysaccharides Are Regulated by a Complex of RNA Binding Proteins

期刊: JOURNAL OF IMMUNOLOGY, 2020; 204 (5)

The IL1A and IL1B genes lie in close proximity on chromosome 2 near the gene for their natural inhibitor, IL1RN. Despite diverse functions, they are a......

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