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Identification of Long Noncoding RNA H19 as a New Biomarker and Therapeutic Target in Right Ventricular Failure in Pulmonary Arterial Hypertension

期刊: CIRCULATION, 2020; 142 (15)

Background: Right ventricular (RV) function is the major determinant for both functional capacity and survival in patients with pulmonary arterial hyp......

Adult Basic Life Support 2020 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations

期刊: CIRCULATION, 2020; 142 ()

This 2020 International Consensus on Cardiopulmonary Resuscitation (CPR) and Emergency Cardiovascular Care Science With Treatment Recommendations on b......

Personal-Level Protective Actions Against Particulate Matter Air Pollution Exposure: A Scientific Statement From the American Heart Association

期刊: CIRCULATION, 2020; 142 (23)

Since the publication of the last American Heart Association scientific statement on air pollution and cardiovascular disease in 2010, unequivocal evi......

CD4(+) T-Cell Endogenous Cystathionine gamma Lyase-Hydrogen Sulfide Attenuates Hypertension by Sulfhydrating Liver Kinase B1 to Promote T Regulatory Cell Differentiation and Proliferation

期刊: CIRCULATION, 2020; 142 (18)

Background: Hydrogen sulfide (H2S) has antihypertension and anti-inflammatory effects, and its endogenous-generation key enzyme cystathionine gamma ly......

Initial Invasive Versus Conservative Management of Stable Ischemic Heart Disease in Patients With a History of Heart Failure or Left Ventricular Dysfunction Insights From the ISCHEMIA Trial

期刊: CIRCULATION, 2020; 142 (18)

Background: Whether an initial invasive strategy in patients with stable ischemic heart disease and at least moderate ischemia improves outcomes in th......

Treatment of Masked Hypertension with a Chinese Herbal Formula A Randomized, Placebo-Controlled Trial

期刊: CIRCULATION, 2020; 142 (19)

BACKGROUND: Masked hypertension is associated with adverse cardiovascular outcomes. Nonetheless, no randomized controlled trials exist in the treatmen......

A Unique Population of Regulatory T Cells in Heart Potentiates Cardiac Protection From Myocardial Infarction

期刊: CIRCULATION, 2020; 142 (20)

Background: Regulatory T cells (Tregs), traditionally recognized as potent suppressors of immune response, are increasingly attracting attention becau......

Complex Arrhythmia Syndrome in a Knock-In Mouse Model Carrier of the N98S Calm1 Mutation

期刊: CIRCULATION, 2020; 142 (20)

Background: Calmodulin mutations are associated with arrhythmia syndromes in humans. Exome sequencing previously identified a de novo mutation in CALM......

In Vivo AAV-CRISPR/Cas9-Mediated Gene Editing Ameliorates Atherosclerosis in Familial Hypercholesterolemia

期刊: CIRCULATION, 2020; 141 (1)

Background: Mutations in low-density lipoprotein (LDL) receptor (LDLR) are one of the main causes of familial hypercholesterolemia, which induces athe......

Increased Myocardial Stiffness in Patients With High-Risk Left Ventricular Hypertrophy The Hallmark of Stage-B Heart Failure With Preserved Ejection Fraction

期刊: CIRCULATION, 2020; 141 (2)

Background: Individuals with left ventricular hypertrophy (LVH) and elevated cardiac biomarkers in middle age are at high risk for the development of ......

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