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Can active life mitigate the impact of diabetes on dementia and brain aging?

期刊: ALZHEIMERS & DEMENTIA, 2020; 16 (11)

Introduction: We investigated whether lifelong exposure to stimulating activities (active life, AL) mitigates diabetes-associated dementia risk and br......

PSEN1, PSEN2, and APP mutations in 404 Chinese pedigrees with familial Alzheimer's disease

期刊: ALZHEIMERS & DEMENTIA, 2020; 16 (1)

Introduction: The PSENs/APP mutation distribution in Chinese patients with familial Alzheimer's disease (FAD) remains unclear. We aimed to analyze the......

Leisure activity and social integration mitigate the risk of dementia related to cardiometabolic diseases: A population-based longitudinal study

期刊: ALZHEIMERS & DEMENTIA, 2020; 16 (2)

Introduction: The effect of comorbid cardiometabolic diseases (CMDs), including diabetes, heart diseases, and stroke, on dementia remains unclear. Met......

Metabolomics and incident dementia in older Chinese adults: The Shanghai Aging Study

期刊: ALZHEIMERS & DEMENTIA, 2020; 16 (5)

Introduction: Metabolomics provide a promising tool to understand the pathogenesis and to identify novel biomarkers of dementia. This study aimed to d......

Association of lifespan cognitive reserve indicator with the risk of mild cognitive impairment and its progression to dementia

期刊: ALZHEIMERS & DEMENTIA, 2020; 16 (6)

Introduction: The association of lifespan cognitive reserve (CR) with mild cognitive impairment (MCI) remains controversial. We aimed to examine the a......

World-Wide FINGERS Network: A global approach to risk reduction and prevention of dementia

期刊: ALZHEIMERS & DEMENTIA, 2020; 16 (7)

Reducing the risk of dementia can halt the worldwide increase of affected people. The multifactorial and heterogeneous nature of late-onset dementia, ......

Association of diabetes with stroke and post-stroke dementia: A population-based cohort study

期刊: ALZHEIMERS & DEMENTIA, 2020; 16 (7)

Introduction: The impact of prediabetes and diabetes on stroke and the development of dementia after a stroke remain unclear. Methods: A total of 2655......

Circulating ethanolamine plasmalogen indices in Alzheimer's disease: Relation to diagnosis, cognition, and CSF tau

期刊: ALZHEIMERS & DEMENTIA, 2020; 16 (9)

Introduction: Altered lipid metabolism is implicated in Alzheimer's disease (AD), but the mechanisms remain obscure. Aging-related declines in circula......

Sleep characteristics and cerebrospinal fluid biomarkers of Alzheimer's disease pathology in cognitive y intact older adults: The CABLE study

期刊: ALZHEIMERS & DEMENTIA, 2020; 16 (8)

Introduction: This study tested the self-reported sleep characteristics associated with cerebrospinal fluid (CSF) Alzheimer's disease (AD) biomarkers ......

Prevalence and incidence of dementia in an older Chinese population over two decades: The role of education

期刊: ALZHEIMERS & DEMENTIA, 2020; 16 (12)

Introduction: Secular trends of dementia prevalence and incidence have rarely been studied in the Chinese population. Methods: We examined the changes......

The APOE epsilon 4 exerts differential effects on familial and other subtypes of Alzheimer's disease

期刊: ALZHEIMERS & DEMENTIA, 2020; 16 (12)

Introduction: The genetic risk effects of apolipoprotein E (APOE) on familial Alzheimer's disease (FAD) with or without gene mutations, sporadic AD (S......

Tackling challenges in care of Alzheimer's disease and other dementias amid the COVID-19 pandemic, now and in the future

期刊: ALZHEIMERS & DEMENTIA, 2020; 16 (11)

We have provided an overview on the profound impact of COVID-19 upon older people with Alzheimer's disease and other dementias and the challenges enco......

Quantitative proteomics reveals distinct composition of amyloid plaques in Alzheimer's disease

期刊: ALZHEIMERS & DEMENTIA, 2019; 15 (3)

Introduction: We investigated the proteomic profiles of amyloid plaques (APs) from Alzheimer's disease (AD) and age-matched non-AD brains and APP/PS1 ......

JIF:14.42

Alteration in sleep architecture and electroencephalogram as an early sign of Alzheimer's disease preceding the disease pathology and cognitive decline

期刊: ALZHEIMERS & DEMENTIA, 2019; 15 (4)

Objective: The present work aims to evaluate the significance of sleep disturbance and electroencephalogram (EEG) alteration in the early stage of Alz......

JIF:14.42

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