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Ubiquitination by a Mycobacterium protein that mimics E1 and E3 activities

期刊: EMBO REPORTS, 2021; 22 (6)

Mycobacterium tuberculosis (Mtb) has evolved various strategies to co-opt the host ubiquitin network to facilitate its proliferation. In the current i......

Fatty acid oxidation is required for embryonic stem cell survival during metabolic stress

期刊: EMBO REPORTS, 2021; 22 (6)

Metabolic regulation is critical for the maintenance of pluripotency and the survival of embryonic stem cells (ESCs). The transcription factor Tfcp2l1......

MICAL2PV suppresses the formation of tunneling nanotubes and modulates mitochondrial trafficking

期刊: EMBO REPORTS, 2021; 22 (7)

Tunneling nanotubes (TNTs) are actin-rich structures that connect two or more cells and mediate cargo exchange between spatially separated cells. TNTs......

Reversing neural circuit and behavior deficit in mice exposed to maternal inflammation by Zika virus

期刊: EMBO REPORTS, 2021; 22 (8)

Zika virus (ZIKV) infection during pregnancy is linked to various developmental brain disorders. Infants who are asymptomatic at birth might have post......

Snail enhances arginine synthesis by inhibiting ubiquitination-mediated degradation of ASS1

期刊: EMBO REPORTS, 2021; 22 (8)

Snail is a dedicated transcriptional repressor and acts as a master inducer of EMT and metastasis, yet the underlying signaling cascades triggered by ......

SCFJFK is functionally linked to obesity and metabolic syndrome

期刊: EMBO REPORTS, 2021; 22 (7)

Dysregulation of lipid metabolism could lead to the development of metabolic disorders. We report here that the F-box protein JFK promotes excessive l......

MacroH2A1.2 deficiency leads to neural stem cell differentiation defects and autism-like behaviors

期刊: EMBO REPORTS, 2021; 22 (7)

The development of the nervous system requires precise regulation. Any disturbance in the regulation process can lead to neurological developmental di......

O-GlcNAcylation of TDP-43 suppresses proteinopathies and promotes TDP-43's mRNA splicing activity

期刊: EMBO REPORTS, 2021; 22 (6)

Pathological TDP-43 aggregation is characteristic of several neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and frontotempo......

TRPV1 sustains microglial metabolic reprogramming in Alzheimer's disease

期刊: EMBO REPORTS, 2021; 22 (6)

As the brain-resident innate immune cells, reactive microglia are a major pathological feature of Alzheimer's disease (AD). However, the exact role of......

RANKL from bone marrow adipose lineage cells promotes osteoclast formation and bone loss

期刊: EMBO REPORTS, 2021; 22 (7)

Receptor activator of NF-kappa B ligand (RANKL) is essential for osteoclast formation and bone remodeling. Nevertheless, the cellular source of RANKL ......

Curcumin prevents obesity by targeting TRAF4-induced ubiquitylation in m(6)A-dependent manner

期刊: EMBO REPORTS, 2021; 22 (5)

Obesity has become a major health problem that has rapidly prevailed over the past several decades worldwide. Curcumin, a natural polyphenolic compoun......

RNA-binding protein RBM47 stabilizes IFNAR1 mRNA to potentiate host antiviral activity

期刊: EMBO REPORTS, 2021; 22 (8)

The type I interferon (IFN-I, IFN-alpha/beta)-mediated immune response is the first line of host defense against invading viruses. IFN-alpha/beta bind......

Mycobacterium tuberculosis protein kinase G acts as an unusual ubiquitinating enzyme to impair host immunity

期刊: EMBO REPORTS, 2021; 22 (6)

Upon Mycobacterium tuberculosis (Mtb) infection, protein kinase G (PknG), a eukaryotic-type serine-threonine protein kinase (STPK), is secreted into h......

Whole-genome analysis of TET dioxygenase function in regulatory T cells

期刊: EMBO REPORTS, 2021; 22 (8)

TET methylcytosine dioxygenases are essential for the stability and function of regulatory T cells (Treg cells), which maintain immune homeostasis and......

Lysine demethylase LSD1 delivered via small extracellular vesicles promotes gastric cancer cell stemness

期刊: EMBO REPORTS, 2021; 22 (8)

Several studies have examined the functions of nucleic acids in small extracellular vesicles (sEVs). However, much less is known about the protein car......

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