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Niazirin from Moringa oleifera Lam. attenuates high glucose-induced oxidative stress through PKC zeta/Nox4 pathway

期刊: PHYTOMEDICINE, 2021; 86 ()

Background: Diabetic complications-coronary atherosclerosis is closely related to the increased reactive oxygen species (ROS) induced by hyperglycemia......

Effects of Yunanan Baiyao adjunct therapy on postoperative recovery and clinical prognosis of patients with traumatic brain injury: A randomized controlled trial

期刊: PHYTOMEDICINE, 2021; 89 ()

Background: Effective therapies are needed to prevent the secondary injury and poor prognosis associated with emergency craniotomy of traumatic brain ......

Yangonin modulates lipid homeostasis, ameliorates cholestasis and cellular senescence in alcoholic liver disease via activating nuclear receptor FXR

期刊: PHYTOMEDICINE, 2021; 90 ()

Background: : Alcoholic liver disease (ALD) is a progressive disease beginning with simple steatosis but can progress to alcoholic steatohepatitis, fi......

Therapeutic options of TCM for organ injuries associated with COVID-19 and the underlying mechanism

期刊: PHYTOMEDICINE, 2021; 85 ()

Background: Coronavirus disease-2019 (COVID-19) caused by infection with severe acute respiratory coronavirus-2 (SARS-CoV-2) has been spreading rapidl......

Identification of molecular anti-metastasis mechanisms of lycorine in colorectal cancer by RNA-seq analysis

期刊: PHYTOMEDICINE, 2021; 85 ()

Background: Colorectal cancer (CRC) is one of the most common malignancies worldwide. Metastasis is the major cause of death in patients with CRC. Lyc......

Hydroxysafflor yellows alleviate thrombosis and acetaminophen-induced toxicity in vivo by enhancing blood circulation and poison excretion

期刊: PHYTOMEDICINE, 2021; 87 ()

Background: Hydroxysafflor yellow A (HSYA) from the flower of Carthamus tinctorius (Safflower) has been reported to have various pharmacological effec......

Dolomiaea souliei ethyl acetate extract protected against alpha-naphthylisothiocyanate-induced acute intrahepatic cholestasis through regulation of farnesoid x receptor-mediated bile acid metabolism

期刊: PHYTOMEDICINE, 2021; 87 ()

Background: Cholestasis is characterized by accumulation of bile components in liver and systemic circulation. Restoration of bile acid homeostasis vi......

Bushen-Huatan-Yizhi formula reduces spatial learning and memory challenges through inhibition of the GSK-3 beta/CREB pathway in AD-like model rats

期刊: PHYTOMEDICINE, 2021; 90 ()

Background: There is an increase in cases of Alzheimer's disease (AD) stemming from a globally ageing population demographic. Although substantial res......

Re-Du-Ning injection ameliorates LPS-induced lung injury through inhibiting neutrophil extracellular traps formation

期刊: PHYTOMEDICINE, 2021; 90 ()

Background: Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are life-threatening diseases and could occur in severe COVID-19 pa......

Uncovering the mechanism of the Shenzhi Jiannao formula against vascular dementia using a combined network pharmacology approach and molecular biology

期刊: PHYTOMEDICINE, 2021; 90 ()

Background: Shenzhi Jiannao formula (SZJNF) is a herbal prescription which is used for detoxification, dredging collaterals, and activating blood circ......

Koumine modulates spinal microglial M1 polarization and the inflammatory response through the Notch-RBP-J kappa signaling pathway, ameliorating diabetic neuropathic pain in rats

期刊: PHYTOMEDICINE, 2021; 90 ()

Background: Diabetic neuropathic pain (DNP), a complication of diabetes, has serious impacts on human health. As the pathogenesis of DNP is very compl......

Systems pharmacological study illustrates the immune regulation, anti-infection, anti-inflammation, and multi-organ protection mechanism of Qing-Fei-Pai-Du decoction in the treatment of COVID-19

期刊: PHYTOMEDICINE, 2021; 85 ()

Background: The traditional Chinese medicine (TCM) formula Qing-Fei-Pai-Du decoction (QFPDD) was the most widely used prescription in China's campaign......

Salvianolic acid A alleviated inflammatory response mediated by microglia through inhibiting the activation of TLR2/4 in acute cerebral ischemia-reperfusion

期刊: PHYTOMEDICINE, 2021; 87 ()

Background: Toll-like receptor 2 and Toll-like receptor 4 (TLR2/4) on microglia have been found as important regulators in the inflammatory response d......

In vitro and in vivo anti-metastatic effect of the alkaliod matrine from Sophora flavecens on hepatocellular carcinoma and its mechanisms

期刊: PHYTOMEDICINE, 2021; 87 ()

Backgrounds: Hepatocellular carcinoma (HCC) is one of the most prevalent and lethal cancer with high metastasis and recurrence rates. Hypoxia-induced ......

Xiao-Chai-Hu-Tang ameliorates tumor growth in cancer comorbid depressive symptoms via modulating gut microbiota-mediated TLR4/MyD88/NF-kappa B signaling pathway

期刊: PHYTOMEDICINE, 2021; 88 ()

Background: Depressive symptoms are thought to promote cancer development and depressive remission has been reported to be effective for defeating can......

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