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A SNP of bacterial blc disturbs gut lysophospholipid homeostasis and induces inflammation through epithelial barrier disruption

期刊: EBIOMEDICINE, 2020; 52 ()

Background: Alteration of commensal bacterial composition is associated with many inflammatory diseases. However, few studies have pinpointed the spec......

Up-regulated FHL2 inhibits ovulation through interacting with androgen receptor and ERK1/2 in polycystic ovary syndrome

期刊: EBIOMEDICINE, 2020; 52 ()

Background: The ovulatory dysfunction mechanisms underlying polycystic ovary syndrome (PCOS) are not completely understood. There is no effective ther......

Intracavernous injection of size-specific stem cell spheroids for neurogenic erectile dysfunction: Efficacy and risk versus single cells

期刊: EBIOMEDICINE, 2020; 52 ()

Background: Intracavernous injection (ICI) of adipose-derived stem cells (ADSCs) has been demonstrated promising for neurogenic erectile dysfunction (......

A small-molecule inhibitor of PCSK9 transcription ameliorates atherosclerosis through the modulation of FoxO1/3 and HNF1 alpha

期刊: EBIOMEDICINE, 2020; 52 ()

Background: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a secreted protein that down-regulates hepatic low-density lipoprotein receptor (......

Silencing of circular RNA HIPK2 in neural stem cells enhances functional recovery following ischaemic stroke

期刊: EBIOMEDICINE, 2020; 52 ()

Background: Circular RNAs (circRNAs) have been reported to be involved in central nervous system (CNS) diseases and to have a close connection with ne......

Foxf1 knockdown promotes BMSC osteogenesis in part by activating the Wnt/beta-catenin signalling pathway and prevents ovariectomy-induced bone loss

期刊: EBIOMEDICINE, 2020; 52 ()

Background: Forkhead box protein f1 (Foxf1) is associated with cell differentiation, and may be a key player in bone homoeostasis. However, the effect......

Canagliflozin impairs blood reperfusion of ischaemic lower limb partially by inhibiting the retention and paracrine function of bone marrow derived mesenchymal stem cells

期刊: EBIOMEDICINE, 2020; 52 ()

Background: Canagliflozin (CANA) administration increases the risk of lower limb amputation in the clinic. The present study aimed to investigate whet......

Long non-coding RNA X-inactive specific transcript silencing ameliorates primary graft dysfunction following lung transplantation through microRNA-21-dependent mechanism

期刊: EBIOMEDICINE, 2020; 52 ()

Background: Primary graft dysfunction (PGD) is a known acute lung injury (ALI) and a major cause of fatality post-lung transplantation. Though some lo......

MiR-18a-downregulated RORA inhibits the proliferation and tumorigenesis of glioma using the TNF-alpha-mediated NF-kappa B signaling pathway

期刊: EBIOMEDICINE, 2020; 52 ()

Background: Glioma has a poor prognosis, and is the most common primary and lethal primary malignant tumor in the central nervous system. Retinoic aci......

Anti-fibrotic effect of decorin in peritoneal dialysis and PD-associated peritonitis

期刊: EBIOMEDICINE, 2020; 52 ()

Background: Progressive peritoneal fibrosis is a common complication in patients on long-term peritoneal dialysis (PD). PD-associated peritonitis is a......

Genome-wide identification of FHL1 as a powerful prognostic candidate and potential therapeutic target in acute myeloid leukaemia

期刊: EBIOMEDICINE, 2020; 52 ()

Background: Acute myeloid leukaemia (AML) is a malignant haematological tumour with high heterogeneity and mortality. A reliable prognostic assessment......

A panel of five plasma proteins for the early diagnosis of hepatitis B virus-related hepatocellular carcinoma in individuals at risk

期刊: EBIOMEDICINE, 2020; 52 ()

Background: To improve the early diagnosis of hepatocellular carcinoma (HCC), more effective diagnostic biomarkers are needed. A combination of biomar......

Identification and external validation of IgA nephropathy patients benefiting from immunosuppression therapy

期刊: EBIOMEDICINE, 2020; 52 ()

Background: Although IgA nephropathy (IgAN), an immune-mediated disease with heterogeneous clinical and pathological phenotypes, is the most common gl......

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