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Discovery of post-translational modifications in immunometabolism by chemical proteomics

期刊: CURRENT OPINION IN BIOTECHNOLOGY, 2021; 68 ()

Metabolic reprogramming of macrophages during immune activation can generate diversified types of small molecule metabolites, which in turn induce pos......

Polyketide pesticides from actinomycetes

期刊: CURRENT OPINION IN BIOTECHNOLOGY, 2021; 69 ()

Natural product derived pesticides have increased in popularity worldwide because of their high efficacy, eco-friendly nature and favorable safety pro......

Engineering insect resistance using plant specialized metabolites

期刊: CURRENT OPINION IN BIOTECHNOLOGY, 2021; 70 ()

Plants in nature are protected against insect herbivory by a wide variety of specialized metabolites. Although insect herbivores generally tolerate th......

RNAs - a new frontier in crop protection

期刊: CURRENT OPINION IN BIOTECHNOLOGY, 2021; 70 ()

Small RNA (sRNA)-mediated RNA interference (RNAi) is a regulatory mechanism conserved in almost all eukaryotes. sRNAs play a critical role in host pat......

Regulatory roles of microRNAs in insect pests: prospective targets for insect pest control

期刊: CURRENT OPINION IN BIOTECHNOLOGY, 2021; 70 ()

At the post-transcriptional level, microRNAs (miRNAs) play an important role in the regulation of gene expression, thereby influencing the outcome of ......

Harnessing in vitro platforms for natural product research: in vitro driven rational engineering and mining (iDREAM)

期刊: CURRENT OPINION IN BIOTECHNOLOGY, 2021; 69 ()

Well-known issues amid in vivo research of natural product discovery and overproduction, such as unculturable or unmanipulable microorganisms, labor-i......

Recent advances in biotechnology for marine enzymes and molecules

期刊: CURRENT OPINION IN BIOTECHNOLOGY, 2021; 69 ()

The marine environment is the most biologically and chemically diverse habitat on Earth, and provides numerous marine-derived products, including enzy......

Recent progress and advanced technology in carbohydrate-based drug development

期刊: CURRENT OPINION IN BIOTECHNOLOGY, 2021; 69 ()

Carbohydrates, one of the most abundant and widespread biomolecules in nature, play indispensable roles in diverse biological functions, and represent......

Heterologous expression and metabolic engineering tools for improving terpenoids production

期刊: CURRENT OPINION IN BIOTECHNOLOGY, 2021; 69 ()

Terpenoids, also referred to as isoprenoids, are the largest group of natural compounds which have contributed significantly to the pharmaceutical ind......

Role of intravital imaging in nanomedicine-assisted anti-cancer therapy

期刊: CURRENT OPINION IN BIOTECHNOLOGY, 2021; 69 ()

Although nanomedicines have provided promising anti-tumor effects in cancer animal models, their clinical success remains limited. One of the most sig......

Challenges of functional expression of complex polyketide biosynthetic gene clusters

期刊: CURRENT OPINION IN BIOTECHNOLOGY, 2021; 69 ()

Polyketide natural products are valuable sources of bioactive molecules such as nutraceuticals and pharmaceuticals. The tremendous development of the ......

Pathway elucidation and engineering of plant-derived diterpenoids

期刊: CURRENT OPINION IN BIOTECHNOLOGY, 2021; 69 ()

Plant-derived diterpenoids are indispensable to plant development, stress-resistance and interaction with environmental microorganisms. Besides signif......

Coordinating precursor supply for pharmaceutical polyketide production in Streptomyces

期刊: CURRENT OPINION IN BIOTECHNOLOGY, 2021; 69 ()

The widely used polyketide pharmaceuticals in medicine and agriculture are mainly produced by Streptomyces species. These compounds, as secondary meta......

Aspergillus terreus as an industrial filamentous fungus for pharmaceutical biotechnology

期刊: CURRENT OPINION IN BIOTECHNOLOGY, 2021; 69 ()

Aspergillus terreus is an important Aspergillus species, which has been applied in the industrial production of the bio-based chemical itaconic acid a......

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