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A multicenter analysis of treatment patterns and clinical outcomes of subsequent therapies after progression on palbociclib in HR+/HER2-metastatic breast cancer

期刊: THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY, 2021; 13 ()

Introduction: Endocrine therapy and cyclin-dependent kinase (CDK) 4/6 inhibitors (CDK4/6i) are standard treatment options for hormone receptor positiv......

Development and external validation of a composite immune-clinical prognostic model associated with EGFR mutation in East-Asian patients with lung adenocarcinoma

期刊: THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY, 2021; 13 ()

Background: EGFR mutation is a common oncogene driver in East Asians with lung adenocarcinoma (LUAD), conferring a favorable prognosis with effective ......

Real-world effectiveness of eribulin in heavily pretreated patients with metastatic breast cancer in China: a multicenter retrospective study

期刊: THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY, 2021; 13 ()

Background: Eribulin is a nontaxane microtubule inhibitor approved in China for patients with advanced breast cancer who show progression after > 2......

High-dose tamoxifen in high-hormone-receptor-expressing advanced breast cancer patients: a phase II pilot study

期刊: THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY, 2021; 13 ()

Background: Tumor progression following endocrine therapy is considered to indicate resistance to endocrine drugs due to a variety of mechanisms. An i......

Anthracycline-containing versus carboplatin-containing neoadjuvant chemotherapy in combination with trastuzumab for HER2-positive breast cancer: the neoCARH phase II randomized clinical trial

期刊: THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY, 2021; 13 ()

Background: Although dual blockade HER2-based neoadjuvant chemotherapy is associated with excellent outcomes for human epidermal growth factor recepto......

First- or second-generation epidermal growth factor receptor tyrosine kinase inhibitors in a large, real-world cohort of patients with non-small cell lung cancer

期刊: THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY, 2021; 13 ()

Background: There are limited comparisons of first- and second-generation EGFR tyrosine kinase inhibitors (TKIs) in large, real-world cohorts of non-s......

Phase I study of pucotenlimab (HX008), an anti-PD-1 antibody, for patients with advanced solid tumors

期刊: THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY, 2021; 13 ()

Background: Pucotenlimab is a humanized immunoglobulin G4 (IgG4) anti programmed cell death protein 1 (anti-PD-1) monoclonal antibody (mAb) with a S22......

Research progress in immune checkpoint inhibitors for lung cancer in China

期刊: THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY, 2021; 13 ()

Immune checkpoint inhibitors (ICIs) have come to play an increasingly prominent role in the treatment of lung cancer, and some are recommended as a fi......

TGFBR2 mutation predicts resistance to immune checkpoint inhibitors in patients with non-small cell lung cancer

期刊: THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY, 2021; 13 ()

Background: Resistance or even hyper-progression to immune checkpoint inhibitors (ICIs) manifesting as accelerated disease progression or death has im......

Apatinib for patients with metastatic biliary tract carcinoma refractory to standard chemotherapy: results from an investigator-initiated, open-label, single-arm, exploratory phase II study

期刊: THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY, 2021; 13 ()

Background: There is no standard therapy for metastatic biliary tract carcinoma (BTC) refractory to first-line chemotherapy. Apatinib, a VEGFR2 tyrosi......

Current treatments and future potential of surufatinib in neuroendocrine tumors (NETs)

期刊: THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY, 2021; 13 ()

Neuroendocrine tumors (NETs) are rare, heterogeneous, often indolent tumors that predominantly originate in the lungs and gastrointestinal tract. An u......

Development and external validation of a novel nomogram for screening Chinese Lynch syndrome: based on a multicenter, population study

期刊: THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY, 2021; 13 ()

Background: This multicenter study aimed to reveal the genetic spectrum of colorectal cancer (CRC) with deficient mismatch repair (dMMR) and build a s......

Determination and clinical significance of bone pseudoprogression in hormone receptor-positive metastatic breast cancer

期刊: THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY, 2021; 13 ()

Background: (99m)Technetium labeled methylene diphosphonate bone scans (BSs) are commonly used to monitor disease progression in bone for patients wit......

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