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Secretory production of spider silk proteins in metabolically engineered Corynebacterium glutamicum for spinning into tough fibers

期刊: METABOLIC ENGINEERING, 2022; 70 ()

Spider dragline silk is a remarkable fiber made of unique proteins-spidroins-secreted and stored as a concentrated aqueous dope in the major ampullate......

JIF:9.835

Combinatorial pathway engineering of Bacillus subtilis for production of structurally defined and homogeneous chitooligosaccharides

期刊: METABOLIC ENGINEERING, 2022; 70 ()

Chitooligosaccharides (COSs) have a widespread range of biological functions and an incredible potential for various pharmaceutical and agricultural a......

JIF:9.835

Improved methylation in E. coli via an efficient methyl supply system driven by betaine

期刊: METABOLIC ENGINEERING, 2022; 72 ()

Methylation reactions are involved in the biosynthesis of various natural molecules, in which S-adenosyl-L-methionine (SAM) acts as the principal biol......

JIF:9.835

De novo production of versatile oxidized kaurene diterpenes in Escherichia coli

期刊: METABOLIC ENGINEERING, 2022; 73 ()

The oxidized kaurene (Ox-Kau) compounds are the core structures of many important diterpenoids with biological activities and economical values. Howev......

JIF:9.835

Dual beta-oxidation pathway and transcription factor engineering for methyl ketones production in Saccharomyces cerevisiae

期刊: METABOLIC ENGINEERING, 2022; 73 ()

Methyl ketones (MK) are highly valuable fatty acid derivatives with broad applications. Microbes based biosynthesis represents an alternative route fo......

JIF:9.835

Engineering of Corynebacterium glutamicum for high-level gamma-aminobutyric acid production from glycerol by dynamic metabolic control

期刊: METABOLIC ENGINEERING, 2022; 69 ()

Synthetic biology seeks to reprogram microbial cells for efficient production of value-added compounds from low-cost renewable substrates. A great cha......

JIF:9.835

Metabolic engineering of the oleaginous alga Nannochloropsis for enriching eicosapentaenoic acid in triacylglycerol by combined pulling and pushing strategies

期刊: METABOLIC ENGINEERING, 2022; 69 ()

The marine alga Nannochloropsis oceanica has been considered as a promising photosynthetic cell factory for synthesizing eicosapentaenoic acid (EPA), ......

JIF:9.835

Engineering of tomato type VI glandular trichomes for trans-chrysanthemic acid biosynthesis, the acid moiety of natural pyrethrin insecticides

期刊: METABOLIC ENGINEERING, 2022; 72 ()

Glandular trichomes, known as metabolic cell factories, have been proposed as highly suitable for metabolically engineering the production of plant hi......

JIF:9.835

Engineering tropane alkaloid production and glyphosate resistance by overexpressing AbCaM1 and G2-EPSPS in Atropa belladonna

期刊: METABOLIC ENGINEERING, 2022; 72 ()

Atropa belladonna is an important industrial crop for producing anticholinergic tropane alkaloids (TAs). Using glyphosate as selection pressure, trans......

JIF:9.835

Multilevel metabolic engineering of Bacillus licheniformis for de novo biosynthesis of 2-phenylethanol

期刊: METABOLIC ENGINEERING, 2022; 70 ()

Due to its pleasant rose-like scent, 2-phenylethanol (2-PE) has been widely used in the fields of cosmetics and food. Microbial production of 2-PE off......

JIF:9.835

Metabolic engineering of Saccharomyces cerevisiae for gram-scale diosgenin production

期刊: METABOLIC ENGINEERING, 2022; 70 ()

Diosgenin (DSG) is a naturally occurring steroidal saponin with a variety of biological activities that is also an important precursor for the synthes......

JIF:9.835

A butenolide signaling system synergized with biosynthetic gene modules led to effective activation and enhancement of silent oviedomycin production in Streptomyces

期刊: METABOLIC ENGINEERING, 2022; 72 ()

Secondary metabolic gene clusters widely exist in the genomes of Streptomyces but mostly remain silent. To awaken this hidden reservoir of natural pro......

JIF:9.835

Systematic identification of Ocimum sanctum sesquiterpenoid synthases and (-)-eremophilene overproduction in engineered yeast

期刊: METABOLIC ENGINEERING, 2022; 69 ()

Plant-derived natural active products have attracted increasing attention for use in flavors and perfumes. These compounds also have applications in i......

JIF:9.835

Metabolic engineering of the malonyl-CoA pathway to efficiently produce malonate in Saccharomyces cerevisiae

期刊: METABOLIC ENGINEERING, 2022; 73 ()

Malonate is a platform chemical that has been utilized to synthesize many valuable chemical compounds. Here, Saccharomyces cerevisiae was metabolicall......

JIF:9.835

Engineering Halomonas bluephagenesis via small regulatory RNAs

期刊: METABOLIC ENGINEERING, 2022; 73 ()

Halomonas bluephagenesis, a robust and contamination-resistant microorganism has been developed as a chassis for Next Generation Industrial Biotechnol......

JIF:9.835

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