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Regulation of ferroptosis by bioactive phytochemicals: Implications for medical nutritional therapy

期刊: PHARMACOLOGICAL RESEARCH, 2021; 168 ()

Ferroptosis is an iron- and lipotoxicity-dependent regulated cell death that has been implicated in various diseases, such as cancer, neurodegeneratio......

Tubocapsenolide A targets C-terminal cysteine residues of HSP90 to exert the anti-tumor effect

期刊: PHARMACOLOGICAL RESEARCH, 2021; 166 ()

Heat shock protein 90 (HSP90) is a chaperone protein that has been shown to regulate cancer progression. As a result, HSP90 has emerged as an attracti......

The therapeutic effect of dehydroepiandrosterone (DHEA) on vulvovaginal atrophy

期刊: PHARMACOLOGICAL RESEARCH, 2021; 166 ()

Vulvovaginal atrophy (VVA) is a chronic disease that mostly occurs in postmenopausal women. After menopause, insufficient sex hormones affect the anat......

Cancer-elicited inflammation attenuates response and outcome in tyrosine kinase inhibitor naive patients with advanced NSCLC

期刊: PHARMACOLOGICAL RESEARCH, 2021; 170 ()

Objective: Cancer elicited inflammation is the main environmental cause leading to carcinogenesis and metastasis of non-small cell lung cancer (NSCLC)......

The interaction between autophagy and neuroinflammation in major depressive disorder: From pathophysiology to therapeutic implications

期刊: PHARMACOLOGICAL RESEARCH, 2021; 168 ()

The past decade has revealed neuroinflammation as an important mechanism of major depressive disorder (MDD). Nod-like receptors family pyrin domain co......

Naturally occurring coumestans from plants, their biological activities and therapeutic effects on human diseases

期刊: PHARMACOLOGICAL RESEARCH, 2021; 169 ()

yNaturally occurring coumestans are known as a collection of plant-derived polycyclic aromatic secondary metabolites which are characterized by the pr......

Food reward depends on TLR4 activation in dopaminergic neurons

期刊: PHARMACOLOGICAL RESEARCH, 2021; 169 ()

The rising prevalence of obesity and being overweight is a worldwide health concern. Food reward dysregulation is the basic factor for the development......

Naringin and naringenin as anticancer agents and adjuvants in cancer combination therapy: Efficacy and molecular mechanisms of action, a comprehensive narrative review

期刊: PHARMACOLOGICAL RESEARCH, 2021; 171 ()

Although the rates of many cancers are controlled in Western countries, those of some cancers, such as lung, breast, and colorectal cancer are current......

Regulatory mechanisms and therapeutic targeting of vasculogenic mimicry in hepatocellular carcinoma

期刊: PHARMACOLOGICAL RESEARCH, 2021; 166 ()

Hepatocellular carcinoma (HCC) is a typical hyper-vascular solid tumor; aberrantly rich in tumor vascular network contributes to its malignancy. Conve......

Features and development trends in international standardization of Chinese materia medica in ISO/TC 249

期刊: PHARMACOLOGICAL RESEARCH, 2021; 167 ()

Chinese materia medica (CMM) is indispensable component of Traditional Chinese Medicine (TCM) therapy. With the widespread of TCM around the world, th......

Xiao-Xu-Ming decoction prevented hemorrhagic transformation induced by acute hyperglycemia through inhibiting AGE-RAGE-mediated neuroinflammation

期刊: PHARMACOLOGICAL RESEARCH, 2021; 169 ()

Stroke is one of the leading causes of death worldwide. Hemorrhagic transformation (HT) is a common serious complication of ischemic stroke (IS) and i......

Allopregnanolone in mood disorders: Mechanism and therapeutic development

期刊: PHARMACOLOGICAL RESEARCH, 2021; 169 ()

The neuroactive steroid allopregnanolone (ALLO) is an endogenous positive allosteric modulator of GABA type A receptor (GABA A R), and the down-regula......

Main active components of Jiawei Gegen Qinlian decoction protects against ulcerative colitis under different dietary environments in a gut microbiota-dependent manner

期刊: PHARMACOLOGICAL RESEARCH, 2021; 170 ()

As an effective drug against acute enteritis diarrhea, Gegen Qinlian decoction (GQD) has a history of 2000 years. However, the potential molecular mec......

miR-29 family: A potential therapeutic target for cardiovascular disease

期刊: PHARMACOLOGICAL RESEARCH, 2021; 166 ()

Cardiovascular disease (CVD), including heart failure, myocardial fibrosis and myocardial infarction, etc, remains one of the leading causes of mortal......

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