Background Total neoadjuvant therapy (TNT) is a novel approach for locally advanced rectal cancer (LARC), which attempts to deliver both systemic chem......
Background The impact of HER2 somatic mutations in colorectal carcinoma (CRC) has not been well studied and its relationship with microsatellite insta......
Lessons Learned Bevacizumab combined with S-1 and raltitrexed demonstrated positive antitumor efficacy and acceptable toxicity. This combination might......
Lessons Learned MET overexpression is uncommon, and positive MET immunohistochemistry (1+/2+) was an independent positive prognostic factor for respon......
Background Different genomic characterization in urothelial carcinoma (UC) by site of origin may imply contrasting therapeutic opportunities and patho......
The addition of trastuzumab to chemotherapy regimen is the standard of care for human epidermal growth factor receptor 2 (HER2)-positive advanced gast......
Trial Information ClinicalTrials.gov Identifier: Sponsor: Tianjin Medical University Cancer Institute & Hospital Principal Investigators: Ping Wan......
Background Real-world safety and effectiveness data for trastuzumab plus chemotherapy treatment of patients with HER2-positive metastatic gastric canc......
Background Racial disparities among clinical trial participants present a challenge to assess whether trial results can be generalized into patients r......
Background National Comprehensive Cancer Network (NCCN) guidelines recommend biomarker testing as the first step in the management of patients with ad......
Lessons Learned Subcutaneous injection was an effective route of administration for envafolimab with a favorable pharmacokinetic profile in patients w......
期刊： ONCOLOGIST, ; ()
Introduction Gastric cancer (GC) has a high incidence and mortality rate, especially in East Asians, and about 90% of GCs are adenocarcinomas. Histolo......
期刊： ONCOLOGIST, ; ()
Background Both protracted irinotecan and antiangiogenesis therapy have shown promising efficacy against Ewing sarcoma (EWS). Methods Patients diagnos......
期刊： ONCOLOGIST, ; ()
Background Concomitant use of proton pump inhibitors (PPIs) with capecitabine was suggested to be associated with poor outcomes in gastrointestinal ca......
期刊： ONCOLOGIST, ; ()
Purpose The purpose of this study was to investigate the predictive capability of neutrophil-to-apolipoprotein A1 ratio (NAR) for predicting overall s......
