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Bispecific T cell-engager targeting oncofetal chondroitin sulfate induces complete tumor regression and protective immune memory in mice

期刊: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2023; 42 (1)

BackgroundThe malaria protein VAR2CSA binds oncofetal chondroitin sulfate (ofCS), a unique chondroitin sulfate, expressed on almost all mammalian canc......

Regulating lactate-related immunometabolism and EMT reversal for colorectal cancer liver metastases using shikonin targeted delivery

期刊: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2023; 42 (1)

Background There are few effective medications for treating colorectal cancer and liver metastases (CRLM). The interactions among glycolysis, epitheli......

Paracrine activin B-NF-κB signaling shapes an inflammatory tumor microenvironment in gastric cancer via fibroblast reprogramming

期刊: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2023; 42 (1)

Background Important roles of INHBB in various malignancies are increasingly identified. The underlying mechanisms in gastric cancer (GC) microenviron......

A flexible liposomal polymer complex as a platform of specific and regulable immune regulation for individual cancer immunotherapy

期刊: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2023; 42 (1)

Background The applicability and therapeutic efficacy of specific personalized immunotherapy for cancer patients is limited by the genetic diversity o......

HNRNPL induced circFAM13B increased bladder cancer immunotherapy sensitivity via inhibiting glycolysis through IGF2BP1/PKM2 pathway

期刊: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2023; 42 (1)

BackgroundThe response rate to immunotherapy in patients with bladder cancer (BCa) remains relatively low. Considering the stable existence and import......

Aryl hydrocarbon receptor nuclear translocator limits the recruitment and function of regulatory neutrophils against colorectal cancer by regulating the gut microbiota

期刊: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2023; 42 (1)

BackgroundAlthough the role and mechanism of neutrophils in tumors have been widely studied, the precise effects of aryl hydrocarbon receptor nuclear ......

Biological and clinical impact of membrane EGFR expression in a subgroup of OC patients from the phase IV ovarian cancer MITO-16A/MANGO-OV2A trial

期刊: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2023; 42 (1)

BackgroundValidated prognostic biomarkers for anti-angiogenic therapy using the anti-VEGF antibody Bevacizumab in ovarian cancer (OC) patients are sti......

METTL16 promotes glycolytic metabolism reprogramming and colorectal cancer progression

期刊: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2023; 42 (1)

BackgroundGlycolysis is the key hallmark of cancer and maintains malignant tumor initiation and progression. The role of N6-methyladenosine (m6A) modi......

Lysosome blockade induces divergent metabolic programs in macrophages and tumours for cancer immunotherapy

期刊: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2023; 42 (1)

BackgroundPlatinum-drugs based chemotherapy in clinic increases the potency of tumor cells to produce M2 macrophages, thus leading to poor anti-metast......

Glycogen synthase 1 targeting reveals a metabolic vulnerability in triple-negative breast cancer

期刊: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2023; 42 (1)

BackgroundHypoxia-induced glycogen turnover is implicated in cancer proliferation and therapy resistance. Triple-negative breast cancers (TNBCs), char......

Liver metastasis from colorectal cancer: pathogenetic development, immune landscape of the tumour microenvironment and therapeutic approaches

期刊: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2023; 42 (1)

Colorectal cancer liver metastasis (CRLM) is one of the leading causes of death among patients with colorectal cancer (CRC). Although immunotherapy ha......

RNA-binding protein CCDC137 activates AKT signaling and promotes hepatocellular carcinoma through a novel non-canonical role of DGCR8 in mRNA localization

期刊: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2023; 42 (1)

BackgroundRNA binding proteins (RBPs)-regulated gene expression play a vital role in various pathological processes, including the progression of canc......

FAT4 overexpression promotes antitumor immunity by regulating the β-catenin/STT3/PD-L1 axis in cervical cancer

期刊: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2023; 42 (1)

Background FAT4 (FAT Atypical Cadherin 4) is a member of the cadherin-associated protein family, which has been shown to function as a tumor suppresso......

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