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Quadruple-editing of the MAPK and PI3K pathways effectively blocks the progression of KRAS-mutated colorectal cancer cells

期刊: CANCER SCIENCE, 2021; 112 (9)

Mutated KRAS promotes the activation of the MAPK pathway and the progression of colorectal cancer (CRC) cells. Aberrant activation of the PI3K pathway......

Landscape of immune cell infiltration in clear cell renal cell carcinoma to aid immunotherapy

期刊: CANCER SCIENCE, 2021; 112 (6)

The tumor microenvironment, comprised of tumor cells and tumor-infiltrating immune cells, is closely associated with the clinical outcome of clear cel......

Clinical use of machine learning-based pathomics signature for diagnosis and survival prediction of bladder cancer

期刊: CANCER SCIENCE, 2021; 112 (7)

Traditional histopathology performed by pathologists by the naked eye is insufficient for accurate and efficient diagnosis of bladder cancer (BCa). We......

Ibrutinib improves the efficacy of anti-CD19-CAR T-cell therapy in patients with refractory non-Hodgkin lymphoma

期刊: CANCER SCIENCE, 2021; 112 (7)

The efficacy and side effects of the second-time humanized CD19 chimeric antigen receptor (CD19-CAR) T-cell therapy after unsuccessful first-time anti......

RNA-binding protein SAMD4A inhibits breast tumor angiogenesis by modulating the balance of angiogenesis program

期刊: CANCER SCIENCE, 2021; 112 (9)

Tumor-induced angiogenesis is important for further progression of solid tumors. The initiation of tumor angiogenesis is dictated by a shift in the ba......

Accurate transcriptome assembly by Nanopore RNA sequencing reveals novel functional transcripts in hepatocellular carcinoma

期刊: CANCER SCIENCE, 2021; 112 (9)

The long reads of Nanopore sequencing permit accurate transcript assembly and ease in discovering novel transcripts with potentially important functio......

An AKT/PRMT5/SREBP1 axis in lung adenocarcinoma regulates de novo lipogenesis and tumor growth

期刊: CANCER SCIENCE, 2021; 112 (8)

Protein kinase B (AKT) hyperactivation and de novo lipogenesis are both common in tumor progression. Sterol regulatory element-binding protein 1 (SREB......

LDH-A negatively regulates dMMR in colorectal cancer

期刊: CANCER SCIENCE, 2021; 112 (8)

Although immune checkpoint inhibitors (ICIs) have achieved unprecedented success in dMMR tumors, pMMR tumors accounting for 85% of colorectal cancer (......

Co-immunization with L-Myc enhances CD8(+) or CD103(+) DCs mediated tumor-specific multi-functional CD8(+) T cell responses

期刊: CANCER SCIENCE, 2021; 112 (9)

Renal carcinoma shows a high risk of invasion and metastasis without effective treatment. Herein, we developed a chitosan (CS) nanoparticle-mediated D......

Generation of combined hepatocellular-cholangiocarcinoma through transdifferentiation and dedifferentiation in p53-knockout mice

期刊: CANCER SCIENCE, 2021; 112 (8)

The two principal histological types of primary liver cancers, hepatocellular carcinoma (HCC) and cholangiocarcinoma, can coexist within a tumor, comp......

Phytochemical library screening reveals betulinic acid as a novel Skp2-SCF E3 ligase inhibitor in non-small cell lung cancer

期刊: CANCER SCIENCE, 2021; 112 (8)

Skp2 is overexpressed in multiple cancers and plays a critical role in tumor development through ubiquitin/proteasome-dependent degradation of its sub......

Connexin32 activates necroptosis through Src-mediated inhibition of caspase 8 in hepatocellular carcinoma

期刊: CANCER SCIENCE, 2021; 112 (9)

Necroptosis is an alternative form of programmed cell death that generally occurs under apoptosis-deficient conditions. Our previous work showed that ......

The transcription factor RUNX2 fuels YAP1 signaling and gastric cancer tumorigenesis

期刊: CANCER SCIENCE, 2021; 112 (9)

Despite considerable efforts in the detection and treatment of gastric cancer (GC), the underlying mechanism of the progression of GC remains unknown.......

Arecoline induces epithelial-mesenchymal transformation and promotes metastasis of oral cancer by SAA1 expression

期刊: CANCER SCIENCE, 2021; 112 (6)

Arecoline, the main alkaloid of areca nut, is well known for its role in inducing submucosal fibrosis and oral squamous cell carcinoma (OSCC), however......

Single-nucleotide polymorphism rs4142441 and MYC co-modulated long non-coding RNA OSER1-AS1 suppresses non-small cell lung cancer by sequestering ELAVL1

期刊: CANCER SCIENCE, 2021; 112 (6)

Single-nucleotide polymorphisms (SNP) and long non-coding RNAs (lncRNAs) have been involved in the process of lung cancer. Following clues given by lu......

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